Abstract: A heart valve replacement is provided including a tubular body portion having a proximal end, a distal end and a central portion arranged between said proximal and distal ends, defining a longitudinal direction of the valve replacement and having an inner wall region; a valve having at least one leaflet attached to the inner wall region of the central portion, each one of said leaflets being movable between a closing position and an opening position of the valve, wherein the tubular body portion is fabricated from a combination of a biostable polymer and a biodegradable biomaterial adapted to allow in-growth of tissue of the host and to increase its size concomitantly with surrounding organ structures of a host, and wherein the valve is fabricated of a biostable polymer connected to the biostable polymer of the tubular body portion.

Abstract: A biomimetic, polymeric composite biomaterial designed as a heart valve leaflet substitute that can be used for heart valve repair and/or to fabricate a new-generation of durable heart valve prosthesis.

Abstract: A transcatheter dilatable valve tube prosthesis is provided including a tubular member capable of plastic deformation from a first dimension to a second dimension; a valve component having a plurality of leaflets. The valve component is capable of expansion from the first dimension to the second dimension, and the valve component is secured to an interior portion of the tubular member by an elastomeric glue at two circumferential portions defining an annular cavity therein. An expandable stent is positioned in the annular cavity between the valve component and the tubular member.

Abstract: The present invention relates to an electrospun fully biodegradable vascular valved prosthesis, allowing tissue regeneration and growth potential optionally comprising a bifurcation, preferably T-shaped, a mandrel for electrospinning said vascular valved prosthesis, and a method for electrospinning said vascular valved prosthesis.