Abstract: A composition including an amphiphilic compound capable of self-assembling into liquid crystalline particles and a statin for systemic administration via oral mucosa. A method of lowering blood cholesterol levels in a subject comprising administering the self-assembling liquid crystalline particles and statin via oral mucosa. Preferred dosage forms result in prolonged release of the statin.

Abstract: The present invention relates to a process for producing an extract derived from sugar cane, the process comprising: i) mixing a sugar cane derived product with ethanol to produce an extraction mixture comprising at least about 50% v/v ethanol; ii) allowing a precipitate to form in the extraction mixture; iii) removing the precipitate from the extraction mixture to obtain a supernatant; and iv) removing ethanol from the supernatant to produce the extract derived from sugar cane. The present invention further relates to extracts produced according to the process of the invention. The invention also relates to the use of such extracts in a method of lowering the available calorific value of a food or beverage, in treating or preventing disease, and as a nutritional supplement, dietary supplement, sports nutrition product, food coating or pharmaceutical product.

Abstract: A composition including an amphiphilic compound capable of self-assembling into liquid crystalline particles and a statin for systemic administration via oral mucosa. A method of lowering blood cholesterol levels in a subject comprising administering the self-assembling liquid crystalline particles and statin via oral mucosa. Preferred dosage forms result in prolonged release of the statin.

Abstract: The present invention provides a polyphenol composition comprising sugarcane bagasse and/or sugarcane vinasse. Methods of lowering the odour of the polyphenol composition using activated carbon. Methods of preparing the polyphenol composition following fermentation and distillation of a sugarcane derived product. Sugars and foods/beverages comprising the polyphenol composition and methods of preparing those.

Abstract: The present invention relates to a process for producing an extract derived from sugar cane, the process comprising: i) mixing a sugar cane derived product with ethanol to produce an extraction mixture comprising at least about 50% v/v ethanol; ii) allowing a precipitate to form in the extraction mixture; iii) removing the precipitate from the extraction mixture to obtain a supernatant; and iv) removing ethanol from the supernatant to produce the extract derived from sugar cane. The present invention further relates to extracts produced according to the process of the invention. The invention also relates to the use of such extracts in a method of lowering the available calorific value of a food or beverage, in treating or preventing disease, and as a nutritional supplement, dietary supplement, sports nutrition product, food coating or pharmaceutical product.

Abstract: The application relates to methods and systems for producing a sugar product. The method includes: receiving a first input in a control system representative of a pre-treatment sugar composition characteristic; receiving a second input in the control system representative of a post-treatment sugar product target specification; using the control system to determine at least one operating parameter for a centrifuge and operating the centrifuge in accordance with the at least one determined operating parameter, wherein the at least one determined operating parameter is determined from at least: the first input, the second input, and a correlation relating at least the first input and the second input to the at least one operating parameter; and treating the pre-treatment sugar composition in the centrifuge to produce a post-treatment sugar product with a characteristic that is at or nearer to the target specification than the characteristic of the pre-treatment sugar composition.

Abstract: The present invention provides a low density amorphous sugar comprising one or more sugars or alternate sweeteners and a density lowering agent. The sugar has a bulk density of less than 0.8 g/cm3 and preferably has a lower density than refined white table sugar. The invention further provides methods of making the amorphous sugar including by rapidly drying, such as spray drying and methods of food and beverage preparation using the amorphous sugar.

Abstract: The invention provides an oral disintegrating tablet (ODT) for administration to oral mucosa comprising an amphiphilic compound capable of self-assembling into liquid crystalline particles when contacted with a hydrophilic solvent, a therapeutically effective amount of a 1 to 10 kDa active ingredient and a pharmaceutically acceptable disintegrant, wherein the 1 to 10 kDa active ingredient is orally bioavailable. The water channels of the liquid crystalline particle may be increased in size. ODTs with enhances water channels may also be useful for delivery of active ingredients of less than 1 kDa.

Abstract: The application relates to a method for producing a sugar product and a system thereof comprising receiving a first input in a control system representative of a pre-treatment sugar composition characteristic and/or an additive; receiving a second input representative of a post-treatment sugar product target specification; using the control system to determine at least one operating parameter for addition of the additive to the pre-treatment sugar and adding the additive based on the at least one determined operating parameter, wherein the at least one determined operating parameter is determined from at least: the first input, the second input, and a correlation relating at least the first input and the second input to the at least one operating parameter; and treating the pre-treatment sugar composition by addition of the additive to produce a post-treatment sugar product with a characteristic that is at or nearer to the target specification than the characteristic of the pre-treatment sugar composition.

Abstract: The present invention provides a sweetener composition comprising (i) sucrose, (ii) one or more high intensity sweeteners and (iii) one or more masking agents. The taste masking agent may be a caramel; a low GI crystalline sugar comprising about 0 to 0.5 g/100 g reducing sugars and about 20 mg CE/100 g to about 45 mg CE/100 g polyphenols and the sugar particles have a glucose based glycaemic index of less than 55; and/or an amorphous sugar comprising sucrose, at least about 20 mg CE polyphenols/100 g carbohydrate and a low GI drying agent.

Abstract: An oral disintegrating tablet that forms liquid crystalline particles or liquid crystalline bulk phase upon disintegration. The oral disintegrating tablet is fast disintegrating following contact with saliva and/or the oral mucosa but also provides slowed delivery of the active ingredient to avoid the difficulties associated with the speed of delivery of an active ingredient through the oral mucosa.

Abstract: A composition including an amphiphilic compound capable of self-assembling into liquid crystalline particles and a statin for systemic administration via oral mucosa. A method of lowering blood cholesterol levels in a subject comprising administering the self-assembling liquid crystalline particles and statin via oral mucosa. Preferred dosage forms result in prolonged release of the statin.

Abstract: An oral disintegrating tablet (ODT) comprising an active ingredient, about 1 to about 20% w/w of at least one amphiphilic compound, about 1 to about 60% w/w of at least one disintegrant and about 0.5 to about 5% w/w of at least one binder, wherein the ODT has hardness of at least about 1 kp and wherein, when the ODT contacts a hydrophilic solvent, the amphiphilic compound self-assembles into liquid crystalline particles.

Abstract: The present invention provides an amorphous sugar comprising sucrose, at least about 20 mg CE polyphenols/100 g carbohydrate and a drying agent with a low glycaemic index. The invention further provides an amorphous sugar comprising one or more sugars and a drying agent with a low glycaemic index. The amorphous sugar of the invention may optionally further comprise prebiotics, alternative sweeteners, proteins and lipids. The amorphous sugar of the invention may optionally be aerated. The invention further provides methods of making the amorphous sugar including by rapidly drying, such as spray drying. The invention further provides methods of preparing aerated amorphous sugar. The invention further provides methods of food and beverage preparation using the amorphous sugar.

Abstract: The application relates to methods and systems for producing a sugar product. The method includes: receiving a first input in a control system representative of a pre-treatment sugar composition characteristic; receiving a second input in the control system representative of a post-treatment sugar product target specification; using the control system to determine at least one operating parameter for a centrifuge and operating the centrifuge in accordance with the at least one determined operating parameter, wherein the at least one determined operating parameter is determined from at least: the first input, the second input, and a correlation relating at least the first input and the second input to the at least one operating parameter; and treating the pre-treatment sugar composition in the centrifuge to produce a post-treatment sugar product with a characteristic that is at or nearer to the target specification than the characteristic of the pre-treatment sugar composition.

Abstract: The present invention provides a composition including an amphiphilic compound capable of self-assembling into a liquid crystalline phase; and a niacin compound. In another aspect, the present invention provides a method for the treatment of a disease state comprising administering a therapeutically effective amount of a pharmaceutical composition incorporating that composition.

Abstract: The present invention relates to a process for producing an extract derived from sugar cane, the process comprising: i) mixing a sugar cane derived product with ethanol to produce an extraction mixture comprising at least about 50% v/v ethanol; ii) allowing a precipitate to form in the extraction mixture; iii) removing the precipitate from the extraction mixture to obtain a super-natant; and iv) removing ethanol from the supernatant to produce the extract derived from sugar cane. The present invention further relates to extracts produced according to the process of the invention. The invention also relates to the use of such extracts in a method of lowering the available calorific value of a food or beverage, in treating or preventing disease, and as a nutritional supplement, dietary supplement, sports nutrition product, food coating or pharmaceutical product.

Abstract: The present invention provides food grade sugar particles comprising sucrose crystals, reducing sugars and polyphenols, wherein the sugar composition comprises about 0 to 0.15 g/100 g reducing sugars and about 20 mg/100 g to about 45 mg/100 g polyphenols and the sugar particles have a glucose based glycaemic index of less than 55.

Abstract: The present invention provides a composition including an amphiphilic compound capable of self-assembling into a liquid crystalline phase; and a niacin compound.

Abstract: The present invention provides a composition including an amphiphilic compound capable of self-assembling into a liquid crystalline phase; and a niacin compound. In another aspect, the present invention provides a method for the treatment of a disease state comprising administering a therapeutically effective amount of a pharmaceutical composition incorporating that composition.