Abstract: A particle characterization system including a flow source to produce a stream of particles; a source of light or other energy directed at the stream of particles to cause fluorescence or scattered light to be emitted from the particles; a detector of the fluorescent or scattered light including three or more light receivers in a non-planar arrangement to detect the light emitted by the particles; and a computer which receives information from the light detector regarding light emitted by a particle in response to the source of light or other energy, the computer programmed to determine a characteristic of the particle based on the light collected from the particle.

Abstract: The invention relates to methods of enriching a sperm sample for euploid sperm comprising obtaining a sperm sample from a mammalian male; contacting the sperm cells with a detectable DNA-interacting agent that imparts a sperm cell with a signal intensity proportional to the amount of DNA present in the sperm cell; and separating those sperm cells that have a signal intensity indicative of euploid sperm from those that have a signal intensity indicative of aneuploid sperm.