Abstract: A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time.

Abstract: A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time.

Abstract: A device for supporting and stacking pallets is formed from a relatively small number of components which are removably connected to each other and which can be readily assembled into an operating configuration or disassembled into its individual components. The device, in its assembled configuration, includes channels for removably receiving advertising material or other displays around the outer perimeter of the assembled configuration. The advertising or displays around the perimeter of the device conceal space within the device and the pallet supporting the merchandise on display. The assembled configuration of the device is arranged so that the merchandise supported by the device is at a height to attract the attention of potential consumers. The advertising material around the perimeter of the assembled device, in addition to concealing the space within the device, also serves to attract the attention of potential consumers to the displayed merchandise.

Abstract: A user can interact with a portable device (10, 10A) to store and receive information using a voice-driven interface. Single utterance spoken commands can be used to perform functions such as making calendar entries, generating reminders, generating ToDo items and the like. A portable device (10, 10A) may automatically identify devices which are nearby at the time of an event and store a list of those other devices. Speech recognition and speech synthesis may be performed at a computer system which is remote from the portable device. The portable device may be in only sporadic communication with the computer system.

Abstract: Systems and methods for automatically associating managed digital images with information produced by a print production system are described. Locating an image for reuse is simplified by searching associations. Utilizing digital image associations during a print production process ensures that print jobs are processed reliably, efficiently and accurately.

Abstract: Circulating oil used for removal of sulfur in sour gas wells is contacted with an aqueous solution of an organic amine and allowed to separate into an oil phase and an aqueous amine phase containing the sulfur. The oil is then returned to circulation to the gas well and the aqueous amine phase is removed for regeneration which is accomplished by precipitating the sulfur with CO.sub.2 and stripping out the CO.sub.2 from the aqueous amine solution with heat and/or vacuum.