Abstract: The present invention relates to an orthopedic screw and a corresponding screw driver wherein the screw has a torque driving head with a rounded side a spherical wall for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4° to about 12° and the major diameter of the screw remaining substantially the same. The screw includes a multilobe torque driving recess joined to a cylindrical recess that corresponds to a cylindrical post on the torque driver so as to form a press fit which acts to self-center the screw, to help avoid stripping of the screw/driver interface and to hold the screw in place on the torque driver prior to implantation.

Abstract: The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.

Abstract: Described is managing the changing of software implementations such as applications deployed to enterprise client users or machines. Precedence relationships between deployed applications are specified. To determine which applications to install for a given client, the precedence is applied to the subset of applications assigned or published to the client. At logon or machine reboot, an upgrade process evaluates the deployed applications and any upgrade relationships, setting applications for removal or installation. A user may also install an application that has been designated as optional. Also described is an application lifecycle model for replacing applications. For example, administrators can phase in upgrades as a pilot to a small group of users, roll out upgrades to a larger group, and then provide the application to all users. Upgrades may be mandatory or optional, and replaced programs may be removed and then replaced, or overlaid during installation.

Abstract: An operating sequence for a handheld computing device manages the device to automatically detect cues describing the device's environmental and user actions performed with the device, learn which cues and cue combinations are relevant to predict user actions, and then in response to occurrence of the relevant cues, predictively implementing the appropriate user action or configuring the device in anticipation of user action.

Abstract: The present invention relates to an orthopedic plate and screw system and instruments for surgical fixation of a small bone or bones including specifically the small bones of the spine. The plate facilitates three dimensional contouring to provide for a variety of applications and to accommodate individual variation in bone shape. The plate has a modified x shape including a central trunk portion including one or more screw holes along a longitudinal axis and a set of divergent upper and an oppositely extending set of divergent lower arms, each arm including screw holes which are placed at a radially equal distance but which diverging asymmetrically from the longitudinal axis relative to its paired upper or lower mate. The screws of the system are self-starting, self-tapping screws including the option of partial or full cannulation. In a further embodiment, the plate is intended for use through the length of the spine.

Abstract: An orthopedic screw having a torque driving head with a rounded side a spherical wall for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4 to about 12° and the major diameter of the screw remaining substantially the same meaning that the major diameter is constant to about +/?0.05 mm along the length of the threaded portion. The screw includes a multilobe torque driving recess joined to a cylindrical recess. In a further embodiment, the screw has an insertion tip which is forms a portion of a sphere.

Abstract: This invention describes novel pyrazole compounds of formula III: wherein Ring D is a 5–7 membered monocyclic ring or 8–10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5–8 membered carbocyclo ring; and R2 and R2? are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

Abstract: From a text entry tool, a digital data processing device receives inherently ambiguous user input. Independent of any other user input, the device interprets the received user input against a vocabulary to yield candidates such as words (of which the user input forms the entire word or part such as a root, stem, syllable, affix), or phrases having the user input as one word. The device displays the candidates and applies speech recognition to spoken user input. If the recognized speech comprises one of the candidates, that candidate is selected. If the recognized speech forms an extension of a candidate, the extended candidate is selected. If the recognized speech comprises other input, various other actions are taken.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present invention relates to an orthopedic plate and screw system and instruments for surgical fixation of a small bone or bones. The plate facilitates three dimensional contouring to provide for a variety of applications and to accommodate individual variation in bone shape. The plate has a modified x shape including a central trunk portion including one or more screw holes along a longitudinal axis and a set of divergent upper and an oppositely extending set of divergent lower arms, each arm including screw holes which are placed at a radially equal distance but which diverging asymmetrically from the longitudinal axis relative to its paired upper or lower mate. The screws of the system are self-starting, self-tapping screws including the option of partial or full cannulation.

Abstract: The present invention relates to a cannulated orthopedic screw having a torque driving head with a spherical wall for multiaxial use, a rounded fluted insertion tip and a threaded portion including a cancellous thread contiguous with a non-threaded portion. The threaded portion has a major diameter defined by a spiraling cancellous type thread and a minor diameter. The screw includes a multilobe torque driving recess.

Abstract: The present invention relates to an orthopedic screw having a torque driving head with spherical surface for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a modified cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4 to about 12° and the major diameter of the screw remaining substantially the same meaning that the major diameter is constant to about +/?0.05 mm along the length of the threaded portion.

Abstract: A method and system for implementing policy by accumulating policies for a policy recipient from policy objects associated with a hierarchically organized structure of containers, such as directory containers (sites, domains and organizational units) that includes the policy recipient. Based on administrator input, policy settings for the policy recipient may be accumulated into a specific order by inheriting policy from higher containers, which may enforce their policy settings over those of lower containers. Policy that is not enforced may be blocked at a container. The result is an accumulated set of group policy objects that are ordered by relative strength to resolve any policy conflicts. Policy may be applied to a policy recipient by calling extensions, such as an extension that layers the policy settings into the registry or an extension that uses policy information from the objects according to the ordering thereof. Linking of group policy objects to one or more containers (e.g.

Abstract: This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 and R5 are taken together with the intervening nitrogen to form heterocyclic ring and R is as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1? secretion.

Abstract: Limiting patch size and complexity through heuristics which use file and product attributes to select a subset of reference file versions (prior states) from the set of all file versions. Patches target this set of reference versions. The computing device stores one or more of the prior states. The current state of the file represents at least one of the prior states with an update applied thereto. The invention selects one of the updates from the patch that corresponds to one of the prior states stored on the computing device. The invention applies the selected update to the corresponding prior state to update the file.

Abstract: A support and a method for fluidic assembly are provided. The support has a surface having binding sites adapted to receive micro-components of a type that are applied to the surface using a fluid; and energy absorbing heat producers at selected binding site. Each energy absorbing heat producer is adapted to receive energy and to transduce a portion of the received energy to heat the fluid proximate to the selected binding sites; so that when the micro-components are applied using a fluid that increases viscosity when heated, the heat generated by the energy absorbing heat producers increases the viscosity of the fluid proximate to the selected binding sites to prevent the micro-components from attaching to the selected binding sites.

Abstract: This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2?, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

Abstract: Uninstalling a patch applied to a software product installed on a computer. A current state of a software product is identified. A desired state of the software product is determined. The desired state of the software product represents a state of the software product when a patch applied to the software product is removed from the software product. The patch is removed from the software product to transition the software product from the identified current state to the determined desired state.

Abstract: Allowing a non-privileged user to apply a patch to a software product. A patch is received from a non-privileged user. It is determined if the received patch may be elevated by the non-privileged user for applying to a target software product. The received patch is applied to the target software product if it is determined that the received patch may be elevated by the non-privileged user for applying to the target software product.

Abstract: Applying multiple patches to one or more software products. A plurality of patches is received from a user. A software product targeted by the received plurality of patches is determined. For the determined software product, one or more of the received plurality of patches that are applicable to the software product are identified. The identified one or more patches are applied to the software product as a function of a state of the software product in a single installation transaction.