Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.

Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.

Abstract: A medical devices en-vivo positional determination system and method of surgery using a registration system to create a 3D frame of reference from 2D images and in which the user uses his or her judgement to select points of interest within the 3D frame of reference more accurate hand-held drilling or cutting, using forward kinematic equations calculated on a microcomputer to provide a real-time display of the 3-linear position and 2-angular orientation of a hand-held medical instrument which is linked by a draw wire or a virtual draw wire to a gimbal so as to measure the angle and distance of the instrument from a fixed point.

Abstract: A safety information arrangement is for installation in a first motor vehicle. The arrangement includes a user interface, a receiver, and an electronic processor. The receiver receives a wireless first signal from outside of the first motor vehicle. The wireless first signal is indicative of a second motor vehicle having an elevated likelihood of colliding with the first motor vehicle. An electronic processor is communicatively coupled to the user interface and to the receiver. The electronic processor receives a second signal from the receiver. The second signal is dependent upon the wireless first signal. The electronic processor controls the user interface dependent upon the second signal to thereby present an alert to a driver of the first motor vehicle. The alert warns the driver that the second motor vehicle has the elevated likelihood of colliding with the first motor vehicle.

Abstract: A system and method for use when forming an osteotomy that rely upon an arrangement of surgical instruments with a targeting guide having a handle extending substantially along a longitudinal axis, with one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough. The arrangement allows accurate adjustment of the surgical instruments in relation to the bones targeted for the osteotomy.

Abstract: A backlighting arrangement is for a head up display that presents a virtual image to a human driver of a motor vehicle. The arrangement includes a light source emitting light with a non-uniform brightness over a field of view of the human driver. A diffuser includes a surface through which the light emitted by the light source passes. The surface has a texture that varies with position on the surface. The texture scatters the light such that the brightness of the light over a field of view of the human driver is more uniform after passing through the diffuser at a given average brightness than it would be with a diffuser configured to scatter light independent of position after passing through the diffuser.

Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.

Abstract: A head up display arrangement for a motor vehicle includes a head up display module having a picture generation unit emitting a light field. A plurality of linear polarizers are arranged in a stack. A first of the linear polarizers receives the light field from the picture generation unit. A last of the linear polarizers emits the light field. A windshield reflects the light field from the last linear polarizer such that the reflected light field is visible to a human driver of the motor vehicle as a virtual image.

Abstract: A head up display system presents a virtual image to a human driver of a motor vehicle. A plurality of light emitting devices are substantially aligned in a row and each emits light. There is a direct relationship between an electrical current drawn by each individual light emitting device and a distance each individual light emitting device is disposed from a center of the row. At least one mirror reflects the light emitted by the light emitting devices toward a windshield of the motor vehicle such that the light is reflected by the windshield and is visible to the human driver as the virtual image.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: An applicator is provided for a flowable media, particularly an adhesive contained in a container and the applicator includes an elongate body member having an internal cavity that holds the container. The cavity has a distal end with a breaking means that is actuated by an axial force. Various embodiments of the actuator are shown to apply the force, including a wire cracker and a molded integral handle member with a lever linkage that bears against a ram which holds the ampoule and having a spring arm that rides within the cavity to oppose a pivoting force on the handle. These embodiments also enable single handed use.

Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.

Abstract: An infotainment system for a motor vehicle includes a display screen positioned to be visible by a passenger of the motor vehicle. A storage arrangement stores a collection of video segments to be presented on the display screen. The storage arrangement also stores metadata in association with the video segments. A user interface receives inputs from the passenger. A sensor detects a characteristic of the passenger. A processing arrangement is communicatively coupled to each of the display screen, the collection of video segments, the user interface and the sensor. The processing arrangement selects one of the video segments to present on the display screen. The selecting of the one video segment is dependent upon inputs received from the passenger via the user interface, signals received from the sensor indicative of the characteristic of the passenger, and metadata associated with individual segments.

Abstract: The present disclosure provides compositions and foods that selectively promote the representation and expressed beneficial function of members of a human gut community in ways that promote a healthy gut microbiota and in turn positively impact health. Various examples of compositions and foods, which comprise one or more fiber preparation, are discussed in detail, as are methods of their use.

Abstract: A head up display arrangement for a motor vehicle includes a head up display module having a picture generation unit emitting a light field. A plurality of linear polarizers are arranged in a stack. A first of the linear polarizers receives the light field from the picture generation unit. A last of the linear polarizers emits the light field. A windshield reflects the light field from the last linear polarizer such that the reflected light field is visible to a human driver of the motor vehicle as a virtual image.

Abstract: A head up display arrangement for a motor vehicle includes a head up display producing a virtual image that is visible to a driver of the motor vehicle when he is sitting in a driver's seat and his eyes are above a first vertical level and below a second vertical level. An eye tracking system detects a vertical level of the eyes of the driver and transmits a height signal indicative of the detected vertical level of the eyes of the driver. A motorized seat height adjustment module adjusts a vertical level of the driver's seat. An electronic controller is communicatively coupled to the eye tracking system and to the motorized seat height adjustment module. The electronic controller controls the motorized seat height adjustment module based on the height signal to move the driver's eyes to a vertical position above the first vertical level and below the second vertical level.

Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.

Abstract: The present invention relates to methods of treating subjects having heart failure with preserved ejection fraction (HFpEF) with a sustained-delivery formulation of cardiotonic 5-(pyridinyl)-2(1H)-pyridinone compounds.

Abstract: A motor vehicle includes a rearview camera capturing images of a scene behind the motor vehicle. An electronic processor receives the images captured by the camera. A virtual image projection arrangement is communicatively coupled to the electronic processor and presents a virtual image dependent upon the images captured by the camera. The virtual image is visible by a driver of the vehicle after being reflected by a windshield.

Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.