Abstract: An electrified airport rescue fire fighting (ARFF) vehicle includes at least one front axle, two rear axles, a water tank having a maximum water capacity of greater than or equal to about 3,000 gallons, a battery pack, and one or more electric motors configured to receive power from the battery pack to facilitate accelerating the ARFF vehicle from 0 to 50 miles-per-hour in 25 seconds or less while the water tank is at the maximum water capacity.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. ch2 and ch3) to accomplish selectivity between the various fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) fc molecule, and increased stability and purity of the resulting variant fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.

Abstract: A fire fighting vehicle includes a chassis, tractive elements coupled to the chassis, a pump coupled to the chassis, a discharge fluidly coupled to the pump, an accessory module coupled to the chassis, and an electric motor coupled to the chassis, the pump, and the accessory module. The accessory module is configured to receive a mechanical energy input and provide at least one of electrical energy or fluid energy. The electric motor is configured to provide mechanical energy to drive (a) the pump to provide fluid to the discharge such that the fluid is expelled from the discharge and (b) the accessory module to provide the at least one of electrical energy or fluid energy.

Abstract: A head up display arrangement for a motor vehicle includes a head up display producing a virtual image that is visible to a driver of the motor vehicle when he is sitting in a driver's seat and his eyes are above a first vertical level and below a second vertical level. An eye tracking system detects a vertical level of the eyes of the driver and transmits a height signal indicative of the detected vertical level of the eyes of the driver. A motorized seat height adjustment module adjusts a vertical level of the driver's seat. An electronic controller is communicatively coupled to the eye tracking system and to the motorized seat height adjustment module. The electronic controller controls the motorized seat height adjustment module based on the height signal to move the driver's eyes to a vertical position above the first vertical level and below the second vertical level.

Abstract: A head up display arrangement for a motor vehicle includes a head up display module having a picture generation unit emitting a light field. A plurality of linear polarizers are arranged in a stack. A first of the linear polarizers receives the light field from the picture generation unit. A last of the linear polarizers emits the light field. A windshield reflects the light field from the last linear polarizer such that the reflected light field is visible to a human driver of the motor vehicle as a virtual image.

Abstract: An electrified fire fighting vehicle includes a battery pack, an electric motor, and a controller configured to operate the electric motor using stored energy in the battery pack to provide a performance condition including (i) accelerating the electrified fire fighting vehicle to a driving speed of at least 50 miles-per-hour in an acceleration time and (ii) maintaining or exceeding the driving speed for a period of time. The acceleration time is 30 second or less. An aggregate of the acceleration time and the period of time is at least 3 minutes.

Abstract: An electrified fire fighting vehicle includes a chassis, a cab, a body, a front axle, a rear axle, an engine, a battery pack, a pump system including a water pump, an electromagnetic device, and a power divider coupling the engine to the pump system and the electromagnetic device. The electromagnetic device is electrically coupled to the battery pack. The electromagnetic device has (a) an output coupled to at least one of the front axle or the rear axle and (b) a power take-off coupled to the pump system.

Abstract: An electrified fire fighting vehicle includes a chassis, a cab, a body, a front axle, a rear axle, an engine, a battery pack, a pump system including a water pump, an electromagnetic device electrically coupled to the battery pack and mechanically coupled to at least one of the front axle or the rear axle, and a power divider coupled to the pump system, the engine, and the electromagnetic device.

Abstract: A fluid distribution system includes a first flow meter configured to be positioned along an agent line, a metering valve configured to be positioned downstream of the first flow meter, a second flow meter configured to be positioned downstream of the first flow meter and an eductor, and a controller configured to selectively operate the fluid distribution system in a testing mode where the controller is configured to acquire a first flow rate of a fluid flowing through the first flow meter and a second flow rate of the fluid flowing through the second flow meter, determine a performance characteristic based on the first flow rate and the second flow rate, and modulate a current setting of the metering valve from a first setting to a second setting and conduct the testing mode sequence again at the second setting to verify the fluid distribution system is performing properly.

Abstract: An electrified fire fighting vehicle includes a chassis, a cab, a body, a front axle, a rear axle, an energy storage system, a water pump, and an electromagnetic device electrically coupled to the energy storage system. The electromagnetic device is coupled to the water pump and at least one of the front axle or the rear axle. The electromagnetic device is configured to receive stored energy from the energy storage system and provide a mechanical output to selectively drive the water pump and the at least one of the front axle or the rear axle.

Abstract: A system and method for use when forming an osteotomy that rely upon an arrangement of surgical instruments with a targeting guide having a handle extending substantially along a longitudinal axis, with one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough. The arrangement allows accurate adjustment of the surgical instruments in relation to the bones targeted for the osteotomy.

Abstract: A fire fighting vehicle includes a chassis, a front axle, a rear axle, a fluid tank having a maximum fluid capacity of at least about 6,000 liters, a battery pack, and an electromechanical transmission coupled to the battery pack and at least one of the front axle or the rear axle. The electromechanical transmission includes one or more electric motors configured to receive power from the battery pack to facilitate accelerating the fire fighting vehicle from 0 to 50 miles-per-hour in 30 seconds or less while the fluid tank is at the maximum fluid capacity.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: An electrified fire fighting vehicle includes a chassis, a cab coupled to the chassis, a body coupled to the chassis, a front axle coupled to the chassis, a rear axle coupled to the chassis, a water tank supported by the chassis, an energy storage system coupled to the chassis, a water pump supported by the chassis, and an electromagnetic device electrically coupled to the energy storage system. The electromagnetic device is coupled to the water pump and at least one of the front axle or the rear axle. The electromagnetic device is configured to receive stored energy from the energy storage system and provide a mechanical output to selectively drive the water pump and the at least one of the front axle or the rear axle.

Abstract: A fire fighting vehicle includes a chassis, a front axle, a rear axle, an engine, an energy storage device, an electromechanical transmission, a vehicle subsystem, and a power divider. The electromechanical transmission is (i) coupled to at least one of the front axle or the rear axle and (ii) electrically coupled to the energy storage device. The power divider is positioned between the engine, the vehicle subsystem, and the electromechanical transmission. The power divider includes a first interface coupled to the engine, a second interface coupled to the vehicle subsystem, and a third interface coupled to the electromechanical transmission. The power divider is configured to facilitate (i) selectively coupling the engine to the vehicle subsystem and (ii) selectively coupling the engine to the electromechanical transmission.

Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.

Abstract: A fire fighting vehicle includes a chassis, a front axle, a rear axle, an engine, a battery system, an electromagnetic device, an accessory drive, and a controller. The accessory drive is positioned to receive a mechanical input from the engine and the electromagnetic device. The controller is configured to selectively engage a plurality of operational modes including a standby mode and a hybrid mode. According to the standby mode, the controller is configured to operate the electromagnetic device using stored energy stored in the battery system to drive the accessory drive with the engine off. According to the hybrid mode, the controller is configured to operate both the engine and the electromagnetic device.