Patents by Inventor David Kendall Jung
David Kendall Jung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11582970Abstract: Provided are 2-aminoimidazole-phenyl derivative compounds of Formula (I): which compounds are useful in methods of controlling microbial growth, such as by enhancing the effects of an antibiotic administered in combination with the compound. Compositions including these compounds, devices including these compounds, and methods of using the same are also provided.Type: GrantFiled: March 8, 2018Date of Patent: February 21, 2023Assignee: North Carolina State UniversityInventors: Christian Melander, David Kendall Jung, Samuel Onofre Reyes
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Publication number: 20220000118Abstract: Provided are 2-aminoimidazole-phenyl derivative compounds of Formula (I): which compounds are useful in methods of controlling microbial growth, such as by enhancing the effects of an antibiotic administered in combination with the compound. Compositions including these compounds, devices including these compounds, and methods of using the same are also provided.Type: ApplicationFiled: March 8, 2018Publication date: January 6, 2022Inventors: Christian Melander, David Kendall Jung, Samuel Onofre Reyes
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Patent number: 7888503Abstract: The present invention relates to dihydrobenzodiazepine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dihydrobenzodiazepine derivatives are useful in the treatment of diseases associated with inappropriate ROCK kinase.Type: GrantFiled: October 18, 2005Date of Patent: February 15, 2011Assignee: GlaxoSmithKline LLCInventors: Michael John Alberti, David Kendall Jung
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Patent number: 7560467Abstract: The present invention relates to indazolo-tetrahydropyrimidine-carboxamide derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such indazolo-tetrahydropyrimidine-carboxamide derivatives are useful in the treatment of diseases associated with inappropriate ROCK-1 kinase.Type: GrantFiled: June 18, 2004Date of Patent: July 14, 2009Assignee: SmithKline Beecham CorporationInventors: David Harold Drewry, Brian Evans, Krista B. Goodman, Darren Victor Steven Green, David Kendall Jung, Dennis Lee, Robert A. Stavenger, Sjoerd Nocolaas Wadman
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Publication number: 20090143366Abstract: The present invention relates to dihydrobenzodiazepine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dihydrobenzodiazepine derivatives are useful in the treatment of diseases associated with inappropriate ROCK kinase.Type: ApplicationFiled: October 18, 2005Publication date: June 4, 2009Inventors: Michael John Alberti, David Kendall Jung
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Patent number: 7528127Abstract: It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.Type: GrantFiled: January 5, 2007Date of Patent: May 5, 2009Assignee: CeNes LimitedInventors: Paul L. Feldman, David Kendall Jung, Istvan Kaldor, Gregory J. Pacofsky, Jeffrey A. Stafford, Jeffrey H. Tidwell
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Publication number: 20090054471Abstract: The present invention relates to pyridopyrazolopyrimidine derivatives that are useful pharmacological agents through the inhibition or antagonism of protein kinases, and to processes for the preparation and use of the same. In particular, the present invention relates to compounds that demonstrate protein tyrosine kinase and/or protein serine/threonine kinase inhibition.Type: ApplicationFiled: February 9, 2006Publication date: February 26, 2009Inventors: David Kendall Jung, Michael John Alberti
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Patent number: 7485635Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.Type: GrantFiled: December 5, 2006Date of Patent: February 3, 2009Assignee: CeNes LimitedInventors: Paul L. Feldman, David Kendall Jung, Istvan Kaldor, Gregory J. Pacofsky, Jeffrey A. Stafford, Jeffrey H. Tidwell
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Patent number: 7473689Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.Type: GrantFiled: January 5, 2007Date of Patent: January 6, 2009Assignee: CeNes LimitedInventors: Paul L. Feldman, David Kendall Jung, Istvan Kaldor, Gregory J. Pacofsky, Jeffrey A. Stafford, Jeffrey H. Tidwell
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Publication number: 20080293716Abstract: There is provided a compound of Formula (I) or a salt, solvate, or physiologically functional derivative thereof:Type: ApplicationFiled: January 28, 2005Publication date: November 27, 2008Applicant: SMITHKLINE BEECHAM CORPORATIONInventors: David Harold Drewry, Robert Neil Hunter, III, David Kendall Jung, James Andrew Linn, Clark Sehon, Robert A. Stavenger
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Publication number: 20080275062Abstract: There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof: wherein R1 is hydrogen or C1-6alkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy, C1-4alkoxycarbonyl, C1-4alkylsulfonyl and a group R3R4NSO2 (wherein R3 and R4 are independently hydrogen or C1-4alkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consistinType: ApplicationFiled: January 28, 2005Publication date: November 6, 2008Inventors: David Harold Drewry, David Kendall Jung, James Andrew Linn, Robert Neil Hunter, Dennis Lee, Robert A. Stavenger, Clark Sehon
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Patent number: 7435730Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.Type: GrantFiled: January 5, 2007Date of Patent: October 14, 2008Assignee: CeNeS LimitedInventors: Paul L. Feldman, David Kendall Jung, Istvan Kaldor, Gregory J. Pacofsky, Jeffrey A. Stafford, Jeffrey H. Tidwell
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Patent number: 7279473Abstract: Fused pyradazine derivatives which are usefule as CDK inhibitors are described herein. The described invention alos includes methods of making such fused pyradazine derivatives as wells as methods of using the same in the treatment of hyperproliferative diseases.Type: GrantFiled: December 11, 2002Date of Patent: October 9, 2007Assignee: SmithKline Beecham CorporationInventors: Jennifer G. Badiang, Scott Howard Dickerson, Philip Anthony Harris, David Kendall Jung, Michael Robert Peel, Michael John Reno, Tara Renae Rheault, Kirk Lawrence Stevens, Francis Xavier Tavares, James Marvin Veal
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Patent number: 7166597Abstract: Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, R2, and R4 are various substituent groups, are protein kinase inhibitorsType: GrantFiled: August 22, 2001Date of Patent: January 23, 2007Assignee: Glaxo Group LimitedInventors: Michael John Alberti, Ian Robert Baldwin, Mui Cheung, Stuart Cockerill, Stephen Flack, Philip Anthony Harris, David Kendall Jung, Gregory Peckham, Michael Robert Peel, Jennifer Gabriel Badiang, Kirk Stevens, James Marvin Veal
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Patent number: 7163940Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.Type: GrantFiled: November 26, 2001Date of Patent: January 16, 2007Assignee: SmithKline Beecham CorporationInventors: F. Leslie Boyd, Stanley D Chamberlain, Mui Cheung, Kristjan Gudmundsson, Philip Anthony Harris, Brian A Johns, David Kendall Jung, Michael Robert Peel, Jennifer G Badiang, Connie Jo Sexton
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Patent number: 7160880Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.Type: GrantFiled: May 12, 2000Date of Patent: January 9, 2007Assignee: CeNeS LimitedInventors: Paul L Feldman, David Kendall Jung, Istvan Kaldor, Gregory J. Pacofsky, Jeffrey A. Stafford, Jeffrey H. Tidwell
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Patent number: 7109209Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.Type: GrantFiled: October 7, 2005Date of Patent: September 19, 2006Assignee: SmithKline Beecham CorporationInventors: Michael John Alberti, Stanley D. Chamberlain, Mui Cheung, Kristjan Gudmundsson, Philip Anthony Harris, Brian A. Johns, David Kendall Jung, Michael Robert Peel, Jennifer Badiang Stanford
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Patent number: 7034030Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.Type: GrantFiled: March 20, 2002Date of Patent: April 25, 2006Assignee: SmithKline Beecham CorporationInventors: Michael John Alberti, Stanley D. Chamberlain, Mui Cheung, Kristjan Gudmundsson, Philip Anthony Harris, Brian A. Johns, David Kendall Jung, Michael Robert Peel, Jennifer Badiang Stanford
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Patent number: 6756498Abstract: The invention provides a process for preparing a compound of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from H, halogen, C1-6alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms; R2 is H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulfonyl, C1-6alkoxy substituted by one or more fluorine atoms, halogen, CN, CONR4R5, CO2H, CO2C1-6alkyl, or NHSO2R4; R3 is H or phenyl substituted by SO2C1-6alkyl or SO2NH2; R4 and R5 are independently selected from H, C1-6alkyl, phenyl, phenyl substituted by one or more atoms or groups R6, or together with the nitrogen atom to which they are attached form a saturated 4 to 8 membered ring R6 is halogen, C1-6alkyl, C1-6alkoxy or C1-6alkoxy substituted by one or more fluorine atoms; which comprises rearrangement of an azirine of formula (II) wherein R0 to RType: GrantFiled: October 25, 2002Date of Patent: June 29, 2004Assignee: SmithKline Beecham CorporationInventors: Russ N. Fitzgerald, David Kendall Jung, John F Eaddy
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Publication number: 20030212275Abstract: The invention provides a process for preparing a compound of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from H. halogen, C1-6alkyl, C1-6alkoxy. or C1-6alkoxy substituted by one or more fluorine atoms; R2 is H, C1-6alkyl. C1-6alkyl substituted by one or more fluorine atoms. C1-6alkoxy, C1-6hydroxyalkyl. SC1-6alkyl. C(O)H. C(O)C1-6alkyl. C1-6alkylsulfonyl. C1-6alkoxy substituted by one or more fluorine atoms, halogen.Type: ApplicationFiled: October 25, 2002Publication date: November 13, 2003Inventors: Russ N. Fitzgerald, David Kendall Jung, John F Eaddy