Abstract: The invention relates to an assay. More specifically, the invention relates to an assay for predicting cardiovascular toxicity of a chemotherapeutic agent.

Abstract: A computer-implemented method is provided, for predicting a risk factor for a patient based on histopathological image analysis. The method includes: receiving at least one histological image of a solid tumour; converting the histological image into a graph representation; processing the graph representation using a neural network, wherein the neural network comprises a graph isomorphism network and a convolutional neural network; and determining the risk factor based on an output of the neural network. Also provided is a method of training one or more neural networks for use in such a method.

Abstract: The present invention relates to N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101), or a pharmaceutically acceptable salt thereof, for use as an anti-inflammatory agent, in particular for use in the treatment of immune checkpoint inhibitor-induced colitis.

Abstract: A method, apparatus, and computer readable medium for facilitating communication between a merchant and a client are provided. An example method may include creating a beautician identification record for a beautician, receiving an information related to an interaction between the beautician and a client, determining at least one product or service for the client from the information, and creating, using a processor, a communication to the client. The communication may include an indication of the at least one product or service. The method may also include sending the prescription to the client. Example systems, apparatuses, and computer readable media are also provided.

Abstract: The present invention relates to N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl)benzamide (CXD101), or a pharmaceutically acceptable salt thereof, for use as an anti-inflammatory agent, in particular for use in the treatment of immune checkpoint inhibitor-induced colitis.

Abstract: The invention provides an assay useful in predicting risk of 5-fluorouracil (FU) toxicity in a subject. The subject may be screened for the presence of at least one TYMS polymorphism and/or at least one DPYD polymorphism. Suitable TYMS and DPYD polymorphisms are provided. The presence of one or more of the polymorphisms indicates an increased risk of developing FU toxicity; a negative result may indicate a decreased risk of developing FU toxicity.

Abstract: A hub device that monitors characteristics of a transportation platform, such as a tractor trailer used for transporting goods, may establish connections with a plurality of external sensors. In order to simplify the pairing process between the hub devices and the external sensors, the hub device may be receiving IDs of the sensors to pair to from a remote server. A technician may physically scan tags, for example a barcode or an NFC tag, of the sensors and hub device, which are then transmitted to the remote server in order to identify which hub and sensors should be paired.

Abstract: Quantitative analysis of a tissue sample includes carrying out a ploidy measurement on a plurality of nuclei of the sample to determine the ploidy type of a sample and also carrying out a stroma measurement on a section to determine the stroma type of a sample. The ploidy type, e.g. diploid or non-diploid, and the stroma type, high or low stroma, give an improved patient survival estimate than the ploidy type alone.

Abstract: The invention provides an assay useful in predicting risk of 5-fluorouracil (FU) toxicity in a subject. The subject may be screened for the presence of at least one TYMS polymorphism and/or at least one DPYD polymorphism. Suitable TYMS and DPYD polymorphisms are provided. The presence of one or more of the polymorphisms indicates an increased risk of developing FU toxicity; a negative result may indicate a decreased risk of developing FU toxicity.

Abstract: A new pump design is described. The pump features a casing with a continuous enclosure extending from a power end of the casing to a fluid end of the casing for housing the reciprocating assembly of the pump, which includes a crankshaft, a plurality of control rods coupled to the crankshaft, and a plurality of crossheads coupled to the control rods. A detachable lid is attached to the casing at the power end and the fluid end of the casing, and encloses the reciprocating assembly. An alignment plate oriented substantially parallel to a stroke axis of the pump maintains alignment of the crossheads.

Abstract: A new pump design is described. The pump features a casing with a continuous enclosure extending from a power end of the casing to a fluid end of the casing for housing the reciprocating assembly of the pump, which includes a crankshaft, a plurality of control rods coupled to the crankshaft, and a plurality of crossheads coupled to the control rods. A detachable lid is attached to the casing at the power end and the fluid end of the casing, and encloses the reciprocating assembly. An alignment plate oriented substantially parallel to a stroke axis of the pump maintains alignment of the crossheads.

Abstract: In one aspect, the invention relates to a method of performing upsampling, that includes the steps of: receiving an input image; generating an initial upsampled image using the input image; generating a low-passed image using the input image; and performing self-similarity upsampling using the upsampled image and the low-passed image.

Abstract: Disclosed is a method of performing upscaling that includes the steps of: parsing an input video; breaking the input video into individual frames; performing upscaling on the individual frames to produce upscaled frames; and stitching the upscaled frames together to produce an upscaled video.

Abstract: Quantitative analysis of a tissue sample includes carrying out a ploidy measurement on a plurality of nuclei of the sample to determine the ploidy type of a sample and also carrying out a stroma measurement on a section to determine the stroma type of a sample. The ploidy type, e.g. diploid or non-diploid, and the stroma type, high or low stroma, give an improved patient survival estimate than the ploidy type alone.

Abstract: A new pump design is described. The pump features a casing with a continuous enclosure extending from a power end of the casing to a fluid end of the casing for housing the reciprocating assembly of the pump, which includes a crankshaft, a plurality of control rods coupled to the crankshaft, and a plurality of crossheads coupled to the control rods. A detachable lid is attached to the casing at the power end and the fluid end of the casing, and encloses the reciprocating assembly. An alignment plate oriented substantially parallel to a stroke axis of the pump maintains alignment of the crossheads.

Abstract: A new pump design is described. The pump features a casing with a continuous enclosure extending from a power end of the casing to a fluid end of the casing for housing the reciprocating assembly of the pump, which includes a crankshaft, a plurality of control rods coupled to the crankshaft, and a plurality of crossheads coupled to the control rods. A detachable lid is attached to the casing at the power end and the fluid end of the casing, and encloses the reciprocating assembly. An alignment plate oriented substantially parallel to a stroke axis of the pump maintains alignment of the crossheads.

Abstract: The invention provides an assay useful in predicting risk of 5-fluorouracil (FU) toxicity in a subject. The subject may be screened for the presence of at least one TYMS polymorphism and/or at least one DPYD polymorphism. Suitable TYMS and DPYD polymorphisms are provided. The presence of one or more of the polymorphisms indicates an increased risk of developing FU toxicity; a negative result may indicate a decreased risk of developing FU toxicity.

Abstract: A new pump design is described. The pump features a casing with a continuous enclosure extending from a power end of the casing to a fluid end of the casing for housing the reciprocating assembly of the pump, which includes a crankshaft, a plurality of control rods coupled to the crankshaft, and a plurality of crossheads coupled to the control rods. A detachable lid is attached to the casing at the power end and the fluid end of the casing, and encloses the reciprocating assembly. An alignment plate oriented substantially parallel to a stroke axis of the pump maintains alignment of the crossheads.