Abstract: Disclosed herein is a system and method for deformable image registration of medical image scans. The system and method described herein relate to improving treatment plans for tumors in locations that are susceptible to natural body movements, in particular, to designing radiation treatment as it relates to the respiratory cycle. The exemplary method and system disclosed herein provides a solution to this problem, which reduces the risk of treatment-related side effects and provides a better framework for more aggressive treatment methods where greater accuracy in distribution is required.

Abstract: Described herein are systems and methods for treating, inhibiting, or ameliorating X-linked disorders including Wiskott-Aldrich Syndrome (WAS) and X-linked thrombocytopenia (XLT) in subjects that have been identified or selected as being ones that would benefit from a therapy to treat, inhibit, or ameliorate WAS or XLT. The systems include nuclease and vector donor constructs configured for co-delivery to modify endogenous WAS locus.

Abstract: An embodiment includes a method to increase the efficiency of security checkpoint operations. A security checkpoint kiosk serves as a Relying Party System (RPS). The RPS establishes a secure local connection between the RPS and a User Mobile-Identification-Credential Device (UMD). The RPS sends a user information request to the UMD, via the secure local connection, seeking release of user information associated with a Mobile Identification Credential (MIC). The RPS obtains authentication of the user information received in response to the user information request. The RPS retrieves user travel information based on the user information. The RPS determines that the user travel information matches the user information. When the user travel information matches the user information, the RPS approves the user to proceed past the security checkpoint kiosk.

Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.

Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

Abstract: N The present disclosure relates to a control system (1) for a vehicle (3) to enable communication with a moveable barrier (2)? The control system (1) includes one or more controller (12) arranged to communicate with the moveable barrier (2). The controller (12) determines a current distance (BVD) of the vehicle (3) from the moveable barrier (2). A control signal (CS-n) is generated in dependence on the current distance (BVD). The control signal (CS-n) is configured to control movement of the moveable barrier (2). Further aspects of the present disclosure relate to a moveable barrier (2); a vehicle (3) and a related method.

Abstract: An embodiment includes a method to increase the efficiency of security checkpoint operations. A security checkpoint kiosk serves as a Relying Party System (RPS). The RPS establishes a secure local connection between the RPS and a User Mobile-Identification-Credential Device (UMD). The RPS sends a user information request to the UMD, via the secure local connection, seeking release of user information associated with a Mobile Identification Credential (MIC). The RPS obtains authentication of the user information received in response to the user information request. The RPS retrieves user travel information based on the user information. The RPS determines that the user travel information matches the user information. When the user travel information matches the user information, the RPS approves the user to proceed past the security checkpoint kiosk.

Abstract: A communication system for intra-vehicle communication in a host vehicle includes a master control system including a master controller and a master transceiver, the master control system being configured to receive an input signal to control an on-board vehicle system. The communication system has a slave control system associated with the on-board vehicle system, the slave control system comprising a slave controller and a slave transceiver. The master transceiver and the slave transceiver are configured to establish wireless communication between the master control system and the slave control system. The master control system is configured to receive the input signal and to generate an output signal based on the input signal; and to transmit the output signal to the slave control system to control operation of the on-board vehicle system.

Abstract: The present disclosure generally relates to digital identification credential user interfaces.

Abstract: Novel tools and techniques are provided for implementing software-based network probes for monitoring network devices for fault management. In various embodiments, a computing system may receive, from at least one software-based network probe, a first alert associated with a first device among layer 4 devices disposed in a plurality of networks; may parse and store first alert data from the received first alert in a database, in a standardized format; may perform, using an enrichment system, enrichment of the first alert data, by retrieving first enrichment data from one or more second databases and adding the first enrichment data to the parsed and formatted first alert data in the first database to form first consolidated alert data; and may send the first consolidated alert data to a fault management system for display to a user to facilitate addressing of the first alert by the user.

Abstract: Novel tools and techniques are provided for implementing global Internet Protocol management system (“GIMS”) for monitoring network devices for fault management. In various embodiments, a computing system may receive a first alert associated with a first device among layer 2 and/or layer 3 devices disposed in a plurality of networks; may collect first alert data and/or first device data; may store the first alert together with the collected first alert data and/or first device data as first consolidated alert data in a first database; may perform, using an enrichment system, enrichment of the first alert, by retrieving first enrichment data from one or more second databases and adding the first enrichment data to the first consolidated alert data in the first database; and may send the first consolidated alert data to a fault management system for display to a user to facilitate addressing of the first alert by the user.

Abstract: Systems, methods, and computer-readable media for communicating electronic device secure element data over multiple paths for online payments are provided. In one example embodiment, a method includes, inter alia, at a commercial entity subsystem, receiving, from an electronic device, device transaction data that includes credential data indicative of a payment credential on the electronic device for funding a transaction with a merchant subsystem, accessing a transaction identifier, deriving a transaction key based on transaction key data that includes the accessed transaction identifier, transmitting, to one of the merchant subsystem and the electronic device, merchant payment data that includes a first portion of the credential data and the accessed transaction identifier, and sharing, with a financial institution subsystem using the transaction key, commercial payment data that includes a second portion of the credential data that is different than the first portion of the credential data.

Abstract: The present application relates to plasma cells and plasma cell precursors that express a macromolecule, such as a protein, protein mimetic or a peptide and compositions comprising these plasma cells or plasma cell precursors. The application further relates to methods of using and making the plasma cells and plasma cell precursors that express the macromolecule. Methods of treatment comprising administering the plasma cells or plasma cell precursors are also contemplated.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: A technique for configuring a user equipment (100) for establishing an emergency session is provided. The user equipment (100) is wirelessly connected to a communications network (102). As to a method aspect of the technique, configuration information indicative of one or more networks available for the establishing of the emergency session is received via the communications network (102). A list of networks available for the establishing of the emergency session is maintained based on the received configuration information.

Abstract: A technique for configuring a user equipment (100) for establishing an emergency session is provided. The user equipment (100) is wirelessly connected to a communications network (102). As to a method aspect of the technique, configuration information indicative of one or more networks available for the establishing of the emergency session is received via the communications network (102). A list of networks available for the establishing of the emergency session is maintained based on the received configuration information.

Abstract: A method of and apparatus for generating, storing and transmitting information relating to a session between an endpoint in an enterprise and an endpoint remote from the enterprise to enable the remote endpoint to contact the enterprise endpoint in a subsequent communications session. The information generated includes, at least, a session identifier identifying the session and the identity of the enterprise endpoint. Advantageously the remote endpoint is also provided with the enterprise communication identity or other means to enable the remote endpoint to associate the session identifier with the enterprise's communication identity.

Abstract: A method of communication between two nodes providing online charging functionalities in an IP Multimedia Subsystem (IMS) network is described, wherein a first node is configured to operate as a Charging Triggering Function (CTF) and wherein a second node is configured to operate as an Online Charging Service (OCS). The method may alleviate drawbacks stemming from low availability of the OCS.

Abstract: Apparatus for use within an IP Multimedia Subsystem network and comprising a receiver for receiving for a given user a charging type defining whether the user is a pre-paid user and or a post-paid user. The apparatus further comprises a Charging Triggering Function, CTF, entity for sending accounting information messages relating to said user to an Online Charging Function over an Ro interface or to a Charging Data Function over an Rf interface, and for including with the accounting information messages said charging type.

Abstract: A method of routing signalling plane traffic through or out of an IP Multimedia Subsystem, IMS, network. The method comprises maintaining within user profile data stored in a subscriber database of the IMS network, routing information defining signalling plane routing profiles for a user associated with the user profile data. Said routing information is transferred from the subscriber database to a Call Session Control Function, CSCF, of the IMS network at or following registration of said user to the IMS network. The method then comprises handling a Session Initiation Protocol, SIP, request for said user at the CSCF including adding said routing information into the request and forwarding the SIP request to a next hop node, and, at said next hop node or at a further downstream node, making a routing decision for the SIP request or for related signalling on the basis of the routing information contained within the SIP request.