Abstract: A suture package for retaining a barbed suture is provided. The suture package includes a suture retaining member including an outer wall and an inner wall. The inner wall is radially spaced from the outer wall and defines a suture retaining area therebetween. The inner wall defines a needle retaining area and includes at least one opening therein to permit reception of at least one suture therethrough. The outer wall includes a plurality of inwardly extending tabs configured to engage a cover. The suture package further includes a cover configured to be received within the outer wall of the suture retaining member and to selectively engage the inwardly extending tabs formed thereon.

Abstract: A suture package for retaining a barbed suture is provided. The suture package includes a suture retaining member including an outer wall and an inner wall. The inner wall is radially spaced from the outer wall and defines a suture retaining area therebetween. The inner wall defines a needle retaining area and includes at least one opening therein to permit reception of at least one suture therethrough. The outer wall includes a plurality of inwardly extending tabs configured to engage a cover. The suture package further includes a cover configured to be received within the outer wall of the suture retaining member and to selectively engage the inwardly extending tabs formed thereon.

Abstract: A suture package for retaining a barbed suture is provided. The suture package includes a suture retaining member including an outer wall and an inner wall. The inner wall is radially spaced from the outer wall and defines a suture retaining area therebetween. The inner wall defines a needle retaining area and includes at least one opening therein to permit reception of at least one suture therethrough. The outer wall includes a plurality of inwardly extending tabs configured to engage a cover. The suture package further includes a cover configured to be received within the outer wall of the suture retaining member and to selectively engage the inwardly extending tabs formed thereon.

Abstract: Provided herein are compounds of the Formula (I), (II), and (III): as well as pharmaceutically acceptable salts thereof, wherein the substituents are those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of oncologic diseases.

Abstract: A suture package for retaining a barbed suture is provided. The suture package includes a suture retaining member including an outer wall and an inner wall. The inner wall is radially spaced from the outer wall and defines a suture retaining area therebetween. The inner wall defines a needle retaining area and includes at least one opening therein to permit reception of at least one suture therethrough. The outer wall includes a plurality of inwardly extending tabs configured to engage a cover. The suture package further includes a cover configured to be received within the outer wall of the suture retaining member and to selectively engage the inwardly extending tabs formed thereon.

Abstract: Provided herein are compounds of formula (I): and pharmaceutically acceptable salts thereof, where the substituents are as described herein. These compounds and their pharmaceutical compositions may be useful in the treatment of oncologic diseases.

Abstract: A suture retainer is provided for supplying a surgical needle and an associated length of relatively stiff suture material to a surgical suturing apparatus. The suture retainer generally includes a body portion defining a suture tray and a loading unit positioned on the body portion. The loading unit is provided to retain a surgical needle in a position to be grasped by a surgical suturing apparatus. The suture tray retains the length of relatively stiff suture in a manner which prevents the relatively stiff suture from bending or otherwise being deformed.

Abstract: A suture package for retaining a barbed suture is provided. The suture package includes a suture retaining member including an outer wall and an inner wall. The inner wall is radially spaced from the outer wall and defines a suture retaining area therebetween. The inner wall defines a needle retaining area and includes at least one opening therein to permit reception of at least one suture therethrough. The outer wall includes a plurality of inwardly extending tabs configured to engage a cover. The suture package further includes a cover configured to be received within the outer wall of the suture retaining member and to selectively engage the inwardly extending tabs formed thereon.

Abstract: A suture package for retaining a barbed suture is provided. The suture package includes a suture retaining member including an outer wall and an inner wall. The inner wall is radially spaced from the outer wall and defines a suture retaining area therebetween. The inner wall defines a needle retaining area and includes at least one opening therein to permit reception of at least one suture therethrough. The outer wall includes a plurality of inwardly extending tabs configured to engage a cover. The suture package further includes a cover configured to be received within the outer wall of the suture retaining member and to selectively engage the inwardly extending tabs formed thereon.

Abstract: An anchoring device having an elongate body at a proximal portion, a distal portion of the elongate body forming a loop at a distal portion of the anchoring device, and a pledget placed over the elongate body adjacent a proximal portion of the loop. The loop further includes a plurality of anchors disposed along a surface thereof and the loop. Methods for securing anchoring devices of the present disclosure are also disclosed.

Abstract: A suture retainer is provided for supplying a surgical needle and an associated length of relatively stiff suture material to a surgical suturing apparatus. The suture retainer generally includes a body portion defining a suture tray and a loading unit positioned on the body portion. The loading unit is provided to retain a surgical needle in a position to be grasped by a surgical suturing apparatus. The suture tray retains the length of relatively stiff suture in a manner which prevents the relatively stiff suture from bending or otherwise being deformed.

Abstract: The present disclosure relates to a package for a surgical repair kit, the package including at least a first area configured and dimensioned to receive a surgical mesh and a second area configured and dimensioned to receive an implantable plug.

Abstract: A suture retainer is provided for supplying a surgical needle and an associated length of relatively stiff suture material to a surgical suturing apparatus. The suture retainer generally includes a body portion defining a suture tray and a loading unit positioned on the body portion. The loading unit is provided to retain a surgical needle in a position to be grasped by a surgical suturing apparatus. The suture tray retains the length of relatively stiff suture in a manner which prevents the relatively stiff suture from bending or otherwise being deformed.

Abstract: A suture package for retaining a barbed suture is provided. The suture package includes a suture retaining member including an outer wall and an inner wall. The inner wall is radially spaced from the outer wall and defines a suture retaining area therebetween. The inner wall defines a needle retaining area and includes at least one opening therein to permit reception of at least one suture therethrough. The outer wall includes a plurality of inwardly extending tabs configured to engage a cover. The suture package further includes a cover configured to be received within the outer wall of the suture retaining member and to selectively engage the inwardly extending tabs formed thereon.

Abstract: A suture package for retaining a barbed suture is provided. The suture package includes a suture retaining member including an outer wall and an inner wall. The inner wall is radially spaced from the outer wall and defines a suture retaining area therebetween. The inner wall defines a needle retaining area and includes at least one opening therein to permit reception of at least one suture therethrough. The outer wall includes a plurality of inwardly extending tabs configured to engage a cover. The suture package further includes a cover configured to be received within the outer wall of the suture retaining member and to selectively engage the inwardly extending tabs formed thereon.

Abstract: An anchoring device having an elongate body at a proximal portion, a distal portion of the elongate body forming a loop at a distal portion of the anchoring device. The loop further includes a plurality of anchors disposed along a surface thereof and the loop also including an end effector. Methods for securing anchoring devices of the present disclosure are also disclosed.

Abstract: An anchoring device includes an elongate body having a proximal portion and a distal portion. The proximal portion of the elongate body terminates in a free end and the distal portion forms a loop. The loop includes a proximal portion and a distal portion. and further includes a plurality of anchors disposed along a surface thereof. The plurality of anchors are oriented toward the proximal portion of the elongate body to limit movement of the loop through tissue. A pledget is disposed adjacent the proximal portion of the loop. Methods for securing anchoring devices of the present disclosure are also disclosed.

Abstract: A solid pharmaceutical dosage form, e.g., a tablet, is disclosed which comprises (a) a sustained released matrix core containing i) an at least sparingly water soluble active pharmaceutical ingredient, ii) a hydrophilic polymer, iii) an optional hydrophobic polymer, iv) an optional wax component, and v) optional diluent; and (b) a semi-permeable functional film coating surrounding the core, wherein the dosage form is substantially resistant to dose dumping when administered in the presence of ethanol. A method for making the dosage form is also provided in which the dosage form is coated with a semi-permeable coating.

Abstract: A medical device includes an elongate body having a proximal portion and a distal portion. The proximal portion of the elongate body terminates in a free end and the distal portion forms a loop. The loop includes a proximal portion and a distal portion, and a plurality of barbs disposed along a surface thereof. A pledget is disposed adjacent the proximal portion of the loop. The elongate body, loop, and/or barbs may be formed from shape memory polymers that are configured to change shape in vivo upon application of energy. Methods for securing medical devices of the present disclosure are also disclosed.