Patents by Inventor David Knight

David Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds, compositions and methods
    Publication number: 20090005580
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Application
    Filed: June 19, 2008
    Publication date: January 1, 2009
    Inventors: Andrew McDonald, Gustave Bergnes, Bainian Feng, David J. Morgans, JR., Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Christopher A. Brook
  • Anti-IL-6 Antibodies, Compositions, Methods and Uses
    Publication number: 20080312172
    Abstract: The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: October 30, 2007
    Publication date: December 18, 2008
    Inventors: Jill Giles-Komar, David Knight, David Peritt, Mohit Trikha
  • QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20080300239
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
    Type: Application
    Filed: May 16, 2008
    Publication date: December 4, 2008
    Inventors: Nicholas D. Adams, Joelle Lorraine Burgess, Michael Gerrard Darcy, Carla A. Donatelli, Steven David Knight, Kenneth Allen Newlander, Lance Ridgers, Martha A. Sarpong, Stanley J. Schmidt
  • QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20080293706
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 27, 2008
    Inventors: Amita CHAUDHARI, Dashyant DHANAK, Carla Ann DONATELLI, Thomas H. FAITG, Yanhong FENG, Steven David KNIGHT, Cynthia A. PARRISH, Jeffrey M. RALPH
  • THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20080255115
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives.
    Type: Application
    Filed: August 24, 2007
    Publication date: October 16, 2008
    Inventors: Michael Gerard Darcy, Steven David Knight, Nicholas D. Adams, Stanley J. Schmidt
  • Methods of inhibiting TNF? activity in the blood of a patient
    Patent number: 7425330
    Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: September 16, 2008
    Assignees: Centocor, Inc., New York University
    Inventors: Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
  • Methods of treating rheumatoid arthritis with anti-TNF antibodies
    Patent number: 7416729
    Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: August 26, 2008
    Assignees: Centocor, Inc., New York University
    Inventors: Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
  • METHODS AND APPARATUSES FOR RECORDING AN AUDIO CONFERENCE
    Publication number: 20080183467
    Abstract: In one embodiment, the systems and methods detect audio content shared during a collaboration session; detect a participant associated with originating the audio content; store or record audio content; and automatically associate the audio content with the participant.
    Type: Application
    Filed: January 25, 2007
    Publication date: July 31, 2008
    Inventors: (Eric) Zheng Yuan, David Knight, Shawn Farshchi, Eric Montoya
  • Methods of inhibiting or neutralizing TNF? in patients with tissue injury
    Patent number: 7404955
    Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: July 29, 2008
    Assignees: Centocor, Inc., New York University
    Inventors: Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
  • Compounds, Compositions, and Methods
    Publication number: 20080176830
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Application
    Filed: April 13, 2006
    Publication date: July 24, 2008
    Inventors: Nicholas D. Adams, Michael Gerard Darcy, Dashyant Dhanak, Kevin J. Duffy, Duke M. Fitch, Steven David Knight, Kenneth Allen Newlander, Antony N. Shaw
  • METHODS AND APPARATUSES FOR SELECTIVELY ACCESSING AN APPLICATION
    Publication number: 20080165391
    Abstract: In one embodiment, the methods and apparatuses request an application; detect a user requesting the application; detect a profile associated with the user; and grant permission to access the application based on an access parameter.
    Type: Application
    Filed: January 22, 2007
    Publication date: July 10, 2008
    Inventors: Weidong Chen, Lei Zhu, Min Zhu, Chris Kangas, Matthew Sheppard, David Knight
  • METHODS AND APPARATUSES FOR AUTOMATICALLY INITIATING AN APPLICATION
    Publication number: 20080168162
    Abstract: In one embodiment, the methods and apparatuses detect an application associated with a requester; suggest the application based on a requester parameter; select the application by the requester; and automatically initiate the application for the requester.
    Type: Application
    Filed: January 22, 2007
    Publication date: July 10, 2008
    Inventors: Weidong Chen, Lei Zhu, Min Zhu, Chris Kangas, Matthew Sheppard, David Knight
  • METHODS AND APPARATUSES FOR DYNAMICALLY SUGGESTING AN APPLICATION BASED ON A COLLABORATION SESSION
    Publication number: 20080168140
    Abstract: In one embodiment, the methods and apparatuses detect shared content during a collaboration session; detect a content type based on the shared content; suggest an application based on the content type; and initiate the application during the collaboration session.
    Type: Application
    Filed: January 22, 2007
    Publication date: July 10, 2008
    Inventors: Weidong Chen, Lei Zhu, Min Zhu, Chris Kangas, Matthew Sheppard, David Knight
  • METHODS AND APPARATUSES FOR MANAGING THE DISTRIBUTION AND INSTALLATION OF APPLICATIONS
    Publication number: 20080168437
    Abstract: In one embodiment, the methods and apparatuses request an installation of an application; detect a user requesting the application; detect a profile associated with the user; and grant permission to install the application based on an installation permission.
    Type: Application
    Filed: January 22, 2007
    Publication date: July 10, 2008
    Inventors: Weidong Chen, Lei Zhu, Min Zhu, Chris Kangas, Matthew Sheppard, David Knight
  • BAMBOO FLOORING PLANKS WITH GLUELESS LOCKING SYSTEM
    Publication number: 20080141611
    Abstract: The present invention provides a 100% bamboo plank with an interlocking system and associated manufacturing methods. In one embodiment, the 100% bamboo plank comprises first, second, and third layers of 100% bamboo, wherein the layers are laminated together. The layers are independently preconditioned to control moisture content therein. Each layer can be preconditioned by alternately elevating and lowering the moisture content in a plurality of sequential cycles before the layers are laminated together. The middle layer is oriented so its grain is substantially perpendicular to the edges of the plank. The plank had joinery portions formed along the edges, and joinery includes an asymmetric upper joinery member and lower joinery member arrangement for, and at least a portion of the upper joinery member and lower joinery member portions are formed in the second layer.
    Type: Application
    Filed: September 24, 2007
    Publication date: June 19, 2008
    Applicant: Teragren LLC
    Inventors: Yongjin Chen, David Knight
  • Recombinant A2-specific TNF?-specific antibodies
    Patent number: 7374761
    Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: May 20, 2008
    Assignees: Centocor, Inc., New York University
    Inventors: Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
  • Nucleic Acids Encoding Anti-IL-12 Antibodies, and Methods of Production
    Publication number: 20080090290
    Abstract: Isolated nucleic acids encoding an anti-IL-12 antibody or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.
    Type: Application
    Filed: January 29, 2007
    Publication date: April 17, 2008
    Inventors: Jill Giles-Komar, David Knight, David Peritt, Bernard Scallon, David Shealy
  • Methods and apparatuses for managing resources within a virtual room
    Publication number: 20080075118
    Abstract: In one embodiment, the methods and apparatuses display a list configured to represent a plurality of virtual rooms; identify a selected participant device associated with a selected virtual room from the plurality of virtual rooms wherein the selected participant device is a member of the selected virtual room; selectively display content associated with the selected virtual room to the selected participant device; and notify the selected participant device of a change to the content associated with the selected virtual room.
    Type: Application
    Filed: October 13, 2006
    Publication date: March 27, 2008
    Inventors: David Knight, Christopher Daniels, Steffen Matt
  • CALCULATING DEFECT DENSITY BY FILE AND SOURCE MODULE
    Publication number: 20080066050
    Abstract: Techniques are provided for tracking and analyzing defect density by source file or module. Defect density is the number of distinct defects which required changes to be made (to fix the defect) to a particular file or module in a given period of time. This metric is very useful for identifying the most critical areas of weakness of the system and hence the areas where additional investment/action may be taken. For example, this metric can be used to prioritize the area in which unit tests should be written, for which additional automated system tests should be written or which a project should be undertaken to re-write the error prone file or module to improve its quality and maintainability.
    Type: Application
    Filed: September 11, 2007
    Publication date: March 13, 2008
    Inventors: Sandeep Jain, David Knight
  • METHOD FOR ENFORCING CHANGE POLICY BASED ON PROJECT STATE
    Publication number: 20080066049
    Abstract: A set of tools and other mechanisms automatically enforce software development change policies by providing a way to map physical source control system codelines to projects and by providing a way to maintain current project and codeline state information. The set of tools and other mechanisms also provide ways to define change management rules and policies, as well as, ways to evaluate and allow or deny each proposed change against the defined change policy.
    Type: Application
    Filed: September 10, 2007
    Publication date: March 13, 2008
    Inventors: Sandeep Jain, David Knight