Patents by Inventor David Koeplin

David Koeplin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cancer therapy utilizing ex vivo gene transduction
    Patent number: 6110458
    Abstract: A method is provided for eliminating cancer cells from a population of cells containing cancer cells and noncancerous cells in vitro or in vivo comprising: (a) providing a mixture of noncancerous cells and cancer cells; (b) contacting the cancer cells with transgenic cancer cells comprising a foreign gene that renders the transgenic cancer cells susceptible to a therapeutic agent; and (c) contacting the transgenic cancer cells with an amount of said therapeutic agent effective to kill both the transgenic cancer cells and the cancer cells.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: August 29, 2000
    Assignee: University of Rochester
    Inventors: Scott M. Freeman, George N. Abraham, Craig S. McCune, Frederick L. Moolten, David Koeplin
  • Cancer therapy utilizing malignant cells expressing HSV-TK
    Patent number: 5601818
    Abstract: A method is provided for eliminating cancer cells from a population of cells containing cancer cells and noncancerous cells in vitro or in vivo comprising: (a) providing a mixture of noncancerous cells and cancer cells; (b) contacting the cancer cells with transgenic cancer cells comprising a foreign gene such as the herpes virus thymidine kinase gene that renders the transgenic cancer cells susceptible to a therapeutic agent; and (c) contacting the transgenic cancer cells with an amount of said therapeutic agent effective to kill both the transgenic cancer cells and the cancer cells.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: February 11, 1997
    Assignee: University of Rochester
    Inventors: Scott M. Freeman, George N. Abraham, Craig S. McCune, Frederick L. Moolten, David Koeplin