Abstract: The present disclosure provides a method of treating cancer in a subject. The method including administering to the subject: a) a therapeutically effective amount of a compound of formula (I); and b) a therapeutically effective amount of sotorasib, wherein the compound of formula (I) is represented by (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, conformational isomer, tautomer, or a combination thereof. In particular, the present disclosure provides a method of treating a solid tumor (e.g., an advanced or metastatic non-small cell lung cancer) with a therapeutically effective amount of a compound of formula (10b) (i.e., 6-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(Ra)-(2,3-dichlorophenyl)-2,5-dimethylpyrimidin-4(3H)-one) in combination with sotorasib in a subject, wherein the subject has one or more mutations in KRAS, such as KRAS G12C.

Abstract: Provided herein are embodiments of a container with disposal compartment. In some embodiments, the container may fruits having portions, such as pits, that are discarded after the fruits have been consumed. The container may include a disposal compartment to receive the discarded portions.

Abstract: An exercise equipment prophylactic covering system, for use in preventing bodily contact with exercise equipment, and thereby preventing contact with bodily fluids from previous users of said exercise equipment. The system includes a seat cover, a single open ended tubular cover, a double open ended tubular cover, and a bicycle handle bar cover. The seat cover is preferably used on any type of seat, said cover attaching over the top of the seat back. The double open ended tubular cover is preferably used on any bar which does not have an open end or forms a continuous part of an exercise machine, such as the handle bars on step machines and the like. The single open ended tubular cover is preferably used on any equipment which provides an open ended handgrip, such as a pull down bar, dumbbells, barbells, and the like. The bicycle handle bar cover secures over the handle bars of a spinning bicycle.

Abstract: A testing and switching (tester) system is disclosed for information transmission and communications networks and systems and the like. According to a preferred embodiment, a data transmission network is advantageously of the type in which remotely located users or customers are afforded time-shared access to a centrally located computer. The data transmission network includes remotely located switching stations which are linked to the central computer over data transmission lines which include selectively actuated normal and fallback local loops. The network users gain access to the centrally located computer over selectively actuated local lines to the remotely located switching stations. The tester system comprises switching and testing apparatus which includes a programmable tester computer located at the remotely located stations and preferably at the centrally located computer site also.