Abstract: The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: A sensor device for a rolling path insert of a track guide can be loaded by rolling bodies and is pressure-sensitive. The sensor device includes at least one tuple, extending in a rolling direction, of a number of sensors, which can each be signal-connected or are signal-connected to an evaluation device, by means of which a relevant difference signal can be determined from sensor signals of sensor pairs of the at least one tuple. The sensor device can be included in a rolling path insert, a guide carriage and a guide rail for a track guide, and a track guide.

Abstract: There is disclosed a guide carriage for roller-mounted guiding on a guide rail having at least one carriage roller track on which roller members which can be arranged between guide carriages and a guide rail can be rolled, wherein the carriage roller track, in particular in order to establish a load acting on the guide carriage or wear, is associated with a pressure-sensitive sensor device which can be loaded by the roller members and which has sensors which are arranged in a manner distributed in the rolling direction and which in order to evaluate the sensor signals thereof can be connected in terms of signaling to an evaluation device. There are further disclosed a route guide having such a guide carriage and a method for establishing the load on the guide carriage.

Abstract: There is disclosed a guide carriage for roller-mounted guiding on a guide rail having at least one carriage roller track on which roller members which can be arranged between guide carriages and a guide rail can be rolled, wherein the carriage roller track, in particular in order to establish a load acting on the guide carriage or wear, is associated with a pressure-sensitive sensor device which can be loaded by the roller members and which has sensors which are arranged in a manner distributed in the rolling direction and which in order to evaluate the sensor signals thereof can be connected in terms of signaling to an evaluation device. There are further disclosed a route guide having such a guide carriage and a method for establishing the load on the guide carriage.