Abstract: Methods for assaying properties in tissues or organs of drugs and other chemical compounds and substances include ex vivo normothermic perfusion with a fluid containing a test substance to obtain data regarding the tissue or organ, the substance and/or an interaction of the substance and the tissue or organ. The data can be used as, for example, part of a submission to a government regulatory organization.

Abstract: An apparatus for perfusing an organ or tissue including a perfusion circuit for perfusing the organ or tissue with liquid perfusate; and an oxygenation system for oxygenating perfusate that recirculates through the perfusion circuit. The oxygenation system includes an oxygen circuit for delivering oxygen to the liquid perfusate and an air circuit for delivering ambient air to the liquid perfusate. The air may be pumped through the oxygenation system via an air pump. The air or oxygen may be bubble through the perfusate to increase oxygen levels in the perfusate. Such supplemental oxygen may beneficial during hypothermic preservation of organs.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: Disclosed is portable organ transportation system including a mobile cart and an organ container. At least one of the mobile cart and the organ container include a latch for releasably attaching the organ container to the mobile cart. The organ container may be a portable organ preservation device or a portable organ perfusion apparatus.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: A method and a system embodying the method for work request arbitration, comprising receiving a work request, the work request indicating one or more groups from a plurality of groups; determining at least one of a plurality of parameters in accordance with the received work request; determining eligibility to provide work among the one or more groups that have work in a work queue in accordance with a first set of the plurality of parameters; and selecting one of the determined eligible groups to provide the work in accordance with a second set of the plurality of parameters is disclosed.

Abstract: Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a donor tissue having desired cells and undesired cells, perfusing the donor tissue with a perfusion solution, developing edema during perfusion of the donor tissue to form a swelled tissue, and separating the desired cells from undesired cellular material to obtain a cellular product. The methods may also include disrupting the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may result in an increased yield of cellular product that retains sufficient functional integrity to be useful as a transplantation resource.

Abstract: One disclosed embodiment provides an integrated circuit that has a plurality of processors and a plurality of processor trace collection logic units. Each processor trace collection logic unit corresponds with, and is operatively coupled to, one of the processors. A separate filtering logic unit is operatively coupled to the plurality of processor trace collection logic units. In some embodiments of the integrated circuit, each processor trace collection logic unit is operative to continuously collect processor trace information from a corresponding operatively coupled processor. Each filtering logic unit is operative to monitor the continuous processor trace information for occurrence of a predetermined condition, and to store some of the processor trace information to memory in response to occurrence of that condition.

Abstract: A cannula includes a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature.

Abstract: A network processor includes a schedule, sync and order (SSO) module for scheduling and assigning work to multiple processors. The SSO includes an on-deck unit (ODU) that provides a table having several entries, each entry storing a respective work queue entry, and a number of lists. Each of the lists may be associated with a respective processor configured to execute the work, and includes pointers to entries in the table. pointer is added to the list based on an indication of whether the associated processor accepts the WQE corresponding to the pointer.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a coolant container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: One disclosed embodiment provides an integrated circuit that has a plurality of processors and a plurality of processor trace collection logic units. Each processor trace collection logic unit corresponds with, and is operatively coupled to, one of the processors. A separate filtering logic unit is operatively coupled to the plurality of processor trace collection logic units. In some embodiments of the integrated circuit, each processor trace collection logic unit is operative to continuously collect processor trace information from a corresponding operatively coupled processor. Each filtering logic unit is operative to monitor the continuous processor trace information for occurrence of a predetermined condition, and to store some of the processor trace information to memory in response to occurrence of that condition.

Abstract: A method of implementing a processor architecture and corresponding system includes operands of a first size and a datapath of a second size. The second size is different from the first size. Given a first array of registers and a second array of registers, each register of the first and second arrays being of the second size, selecting a first register and corresponding second register from the first array and the second array, respectively, to perform operations of the first size. This allows a user, who is interfacing with the hardware processor through software, to provide data of the datapath bit-width instead of the register bit-width. Advantageously, the user is agnostic to the size of the registers.

Abstract: Examples of a carry chain for performing an operation on operands each including elements of a selectable size is provided. Advantageously, the carry chain adapts to elements of different sizes. The carry chain determines a mask based on a selected size of an element. The carry chain selects, based on the mask, whether to carry a partial result of an operation performed on corresponding first portions of a first operand and a second operand into a next operation. The next operation is performed on corresponding second portions of the first operand and the second operand, and, based on the selection, the partial result of the operation. The carry chain stores, in a memory, a result formed from outputs of the operation and the next operation.

Abstract: An apparatus for perfusing an organ or tissue includes a perfusion circuit for perfusing the organ or tissue; an oxygenator for oxygenating perfusate that circulates through the perfusion circuit; and an oxygen supply device such as an oxygen concentrator or an oxygen generator configured to supply oxygen to the oxygenator. A method of perfusing an organ or tissue includes producing oxygen from a device such as an oxygen concentrator and an oxygen generator; supplying the produced oxygen, preferably as the oxygen is produced, to a perfusate to oxygenate the perfusate; and perfusing the organ or tissue with the oxygenated perfusate. The produced oxygen preferably has a concentration greater than the oxygen concentration in air.

Abstract: A method of providing permissions to consume content objects within a domain includes creating a domain and a domain membership rights object for each member. The domain facilitates the sharing of content objects amongst the members of the domain. The domain membership rights objects for each member include permissions for each member in the domain to consume content objects in the domain.

Abstract: A method and a system embodying the method for work request arbitration, comprising receiving a work request, the work request indicating one or more groups from a plurality of groups; determining at least one of a plurality of parameters in accordance with the received work request; determining eligibility to provide work among the one or more groups that have work in a work queue in accordance with a first set of the plurality of parameters; and selecting one of the determined eligible groups to provide the work in accordance with a second set of the plurality of parameters is disclosed.

Abstract: A method and a system embodying the method for processing conflicting work, comprising: receiving a work request, the work request indicating one or more groups from a plurality of groups; finding work by arbitrating among a plurality of queues of the one or more groups; determining whether the found work conflicts with another work; returning the found work when the determination is negative; and adding the found work into a tag-chain when the determination is affirmative is disclosed.