Patents by Inventor David Kucera

David Kucera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrro[1,2-]pyridazinone compounds
    Patent number: 7582754
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: September 1, 2009
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas Eric Murphy, David Kucera, Zhongxiang Sun, Chinh Viet Tran
  • P-Toluene Sulfonic Acid Salt of 5-Amino-3-(2'-O-Acetyl-3'-Deoxy-Beta-D-Ribofuranosyl)-3H-Thiazole[4,5-d]pyrimidine-2-one and Methods for Preparation
    Publication number: 20090197826
    Abstract: The present disclosure relates to p-toluene sulfonic acid salt of 5-amino-3-(2?-O-acetyl-3?-deoxy-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and to its use in treating conditions such as viral infections, tumors, and cancer. Also disclosed is a method of preparing the p-toluene sulfonic acid salt of 5-amino-3-(2?-O-acetyl-3?-deoxy-?-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and methods for producing furanose compounds which are useful intermediates in the preparation of pharmaceutical compounds such as p-toluene sulfonic acid salt of 5-amino-3-(2?-O-acetyl-3?-deoxy-?-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.
    Type: Application
    Filed: October 16, 2007
    Publication date: August 6, 2009
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: David Kucera, Gregory J. Haley, Erik J. Rueden, Tingmin Wang, Fritz Blatter, Martin Viertelhaus
  • PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS
    Publication number: 20090105473
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: November 6, 2008
    Publication date: April 23, 2009
    Applicant: ANADYS PHARMACEUTICALS, INC.
    Inventors: Stephen E. Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas E. Murphy, David Kucera, Zhongxiang Sun, Chinh V. Tran
  • Pyrro[1,2-b]pyridazinone compounds
    Patent number: 7462611
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus: wherein R4 is selected from Ring A is 5 or 6- membered aryl or heterocyclyl, and the remaining substituents are defined herein.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: December 9, 2008
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Frank Ruebsam, Martin Tran, Stephen E. Webber, Peter Dragovich, Liansheng Li, Douglas Murphy, David Kucera, Zhongxiang Sun, Chinh Viet Tran
  • PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS
    Publication number: 20080031852
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: June 21, 2007
    Publication date: February 7, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas Murphy, David Kucera, Zhongxiang Sun, Chinh Tran
  • HIV PROTEASE INHIBITORS, COMPOSITIONS CONTAINING THE SAME, THEIR PHARMACEUTICAL USES, MATERIALS FOR THEIR SYNTHESIS
    Publication number: 20070066664
    Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Application
    Filed: October 31, 2006
    Publication date: March 22, 2007
    Inventors: David Kucera, Robert Scott
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Publication number: 20070021354
    Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Application
    Filed: June 9, 2006
    Publication date: January 25, 2007
    Inventors: Stacie Canan Koch, Therese Alexander, Benjamin Burke, Tanya Jewell, David Kucera, Maria Linton, Lennert Mitchell, Siegfried Reich, Donald Skalitzky, John Tatlock, Michael Varney, Scott Virgil, Stephen Webber, Stephen Worland, Mark Barvian, Gary Bolton, Frederick Boyer, Jeffrey Machak, Tod Holler, Sean Murphy, Michael Melnick, Vara Josyula
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Publication number: 20050250707
    Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Application
    Filed: June 20, 2005
    Publication date: November 10, 2005
    Inventors: Stacie Canan Koch, Therese Alexander, Benjamin Burke, Tanya Jewell, David Kucera, Maria Linton, Lennert Mitchell, Siegfried Reich, Donald Skalitzky, John Tatlock, Michael Varney, Scott Virgil, Stephen Webber, Stephen Worland, Mark Barvian, Gary Bolton, Frederick Boyer, Jeffrey Machak, Tod Holler, Sean Murphy, Michael Melnick, Vara Josyula
  • Methods of preparing compounds useful as protease inhibitors
    Publication number: 20050153903
    Abstract: The invention relates to methods of preparing compounds of formula (I) that are useful as inhibitors of the HIV protease enzyme. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula (I).
    Type: Application
    Filed: December 3, 2004
    Publication date: July 14, 2005
    Inventors: David Kucera, Nabil Saeed, Robert Scott
  • Methods of preparing compounds useful as protease inhibitors
    Publication number: 20050124673
    Abstract: The invention relates to methods of preparing compounds of formula (I), useful as inhibitors of the HIV protease enzyme. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula (I).
    Type: Application
    Filed: December 3, 2004
    Publication date: June 9, 2005
    Inventors: David Kucera, Robert Scott
  • Novel beta-lactams methods for the preparation of taxanes, and sidechain-bearing taxanes
    Publication number: 20050107605
    Abstract: Novel ?-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling ?-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Application
    Filed: October 20, 2004
    Publication date: May 19, 2005
    Inventors: John Thottathil, Ivan Trifunovich, David Kucera, Wen-Sen Li
  • Process and chiral amine intermediates useful for preparation of antiproliferative 2,4-diaminothiazole amide compounds
    Publication number: 20050026966
    Abstract: This invention relates to a novel process for preparing D-alanine derivatives and bis-toluenesulfonic acid salts thereof useful as intermediates in the preparation of 2,4-diaminothiazole amide compounds and pharmaceutical compositions containing such compounds. The invention also relates to such compounds and compositions that demonstrate antiproliferative activity such as antitumor activity. These compounds and compositions are also useful for treating various diseases and disorders associated with uncontrolled or unwanted cell proliferation and for inhibiting protein kinases.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 3, 2005
    Inventors: David Kucera, Brigitte Yvon