Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: The disclosure provides compositions, methods, and devices for use in delivering Mitomycin-C(MMC), an antineoplastic chemotherapy drug often used for bladder instillations to treat bladder cancer, which degrades in both acidic and alkaline environments. The disclosure provides a solution of buffered MMC (or a different drug) in 50% propylene glycol that maintains a pH from 7.0 to 8.0 when introduced into acidic solutions (pH of 5.0) and is stable when stored at 2-8° C. for greater than 134 days. This formulation can be produced in an FDA registered 503B Outsourcing facility in a pre-filled, ready-to-administer syringe kit with pre-attached closed system transfer device and accessories required for bladder instillation.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: Techniques are disclosed for capturing, transcoding, and caching off-air programming at a location local to the consumer. According to certain embodiments, a device is provided that receives off-air (e.g., broadcast) and/or cable (e.g., ClearQAM) programming via one or more antennas and caches the programming in various streams having various bit rates for later viewing using, for example, Adaptive Bit Rate (ABR) streaming. Such a device can be incorporated in a larger system that can stream content via a data communication network (e.g., the Internet) and the device in a seamless manner. The device also can be controlled by a remote system via the data communication network, and further can be configured to stream content to a remote device via the data communication network.

Abstract: Techniques are disclosed for capturing, transcoding, and caching off-air programming at a location local to the consumer. According to certain embodiments, a device is provided that receives off-air (e.g., broadcast) and/or cable (e.g., ClearQAM) programming via one or more antennas and caches the programming in various streams having various bit rates for later viewing using, for example, Adaptive Bit Rate (ABR) streaming. Such a device can be incorporated in a larger system that can stream content via a data communication network (e.g., the Internet) and the device in a seamless manner. The device also can be controlled by a remote system via the data communication network, and further can be configured to stream content to a remote device via the data communication network.

Abstract: Techniques are disclosed for capturing, transcoding, and caching off-air programming at a location local to the consumer. According to certain embodiments, a device is provided that receives off-air (e.g., broadcast) and/or cable (e.g., ClearQAM) programming via one or more antennas and caches the programming in various streams having various bit rates for later viewing using, for example, Adaptive Bit Rate (ABR) streaming. Such a device can be incorporated in a larger system that can stream content via a data communication network (e.g., the Internet) and the device in a seamless manner. The device also can be controlled by a remote system via the data communication network, and further can be configured to stream content to a remote device via the data communication network.

Abstract: Techniques are disclosed for capturing, transcoding, and caching off-air programming at a location local to the consumer. According to certain embodiments, a device is provided that receives off-air (e.g., broadcast) and/or cable (e.g., ClearQAM) programming via one or more antennas and caches the programming in various streams having various bit rates for later viewing using, for example, Adaptive Bit Rate (ABR) streaming. Such a device can be incorporated in a larger system that can stream content via a data communication network (e.g., the Internet) and the device in a seamless manner. The device also can be controlled by a remote system via the data communication network, and further can be configured to stream content to a remote device via the data communication network.

Abstract: Techniques are disclosed for capturing, transcoding, and caching off-air programming at a location local to the consumer. According to certain embodiments, a device is provided that receives off-air (e.g., broadcast) and/or cable (e.g. ClearQAM) programming via one or more antennas and caches the programming in various streams having various bit rates for later viewing using, for example, Adaptive Bit Rate (ABR) streaming. Such a device can be incorporated in a larger system that can stream content via a data communication network (e.g., the Internet) and the device in a seamless manner. The device also can be controlled by a remote system via the data communication network, and further can be configured to stream content to a remote device via the data communication network.

Abstract: Various arrangements are presented for reducing channel change times. A first tuner of a television receiver may tune to a decryption key transponder stream. The decryption key transponder stream may include a plurality of decryption keys for a plurality of television channels that are transmitted to the television receiver via a plurality of transponder streams. A second tuner of the television receiver may be tuned to a media transponder stream to receive a television channel. Data obtained from the decryption key transponder stream may be used for decoding the television channel.

Abstract: The provisioning of media content to computing devices that might not normally have access thereto. Example types of media or media content may include advertising media, broadcast media, social media, news media, and others.

Abstract: Various arrangements are presented for reducing channel change times. A first tuner of a television receiver may tune to a decryption key transponder stream. The decryption key transponder stream may include a plurality of decryption keys for a plurality of television channels that are transmitted to the television receiver via a plurality of transponder streams. A second tuner of the television receiver may be tuned to a media transponder stream to receive a television channel. Data obtained from the decryption key transponder stream may be used for decoding the television channel.

Abstract: Automation control for water leaks is provided. First sensor readings from first sensors disposed about water supply lines at a home to detect a first type of metrics indicative of water flow may be received and recorded over a first time period. Second sensor readings may be received from a second sensor. A first correlation between the first sensor readings and the second sensor readings may be identified. A first activity profile may be generated based on the first correlation. A first water use profile may be generated based on the first activity profile. First thresholds may be identified based on the first water use profile and may be retained in association with the first activity profile. Water use at the home may be monitored with the first sensors and activity at the home may be monitored with the second sensors. A water leak condition may be determined.

Abstract: Various arrangements are presented for reducing channel change times. A first tuner of a television receiver may tune to a decryption key transponder stream. The decryption key transponder stream may include a plurality of decryption keys for a plurality of television channels that are transmitted to the television receiver via a plurality of transponder streams. A second tuner of the television receiver may be tuned to a media transponder stream to receive a television channel. Data obtained from the decryption key transponder stream may be used for decoding the television channel.

Abstract: Various arrangements for outputting a customized video mosaic are presented. Based on received user input, it may be determined that a customized video mosaic is to be output for presentation. A plurality of television channels to be presented as part of the customized video mosaic may be determined. One or more tuners may be tuned based on the determined plurality of television channels to be presented. The plurality of television channels may be output for presentation to a presentation device. Each of these television channels may be presented by the presentation device as live video simultaneously as part of the customized video mosaic.

Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R5, A1, A2, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Abstract: Techniques are disclosed for capturing, transcoding, and caching off-air programming at a location local to the consumer. According to certain embodiments, a device is provided that receives off-air (e.g., broadcast) and/or cable (e.g. ClearQAM) programming via one or more antennas and caches the programming in various streams having various bit rates for later viewing using, for example, Adaptive Bit Rate (ABR) streaming. Such a device can be incorporated in a larger system that can stream content via a data communication network (e.g., the Internet) and the device in a seamless manner. The device also can be controlled by a remote system via the data communication network, and further can be configured to stream content to a remote device via the data communication network.

Abstract: Various arrangements for targeting advertising to a television viewer are presented. A user interface may be output for presentation that permits the television viewer to select from among a plurality of advertising options. One or more selections may be received from the television viewer from among the plurality of advertising options. A television program may be output for presentation to the television viewer. One or more commercials may be selected that match the one or more selections from among the plurality of advertising options. The one or more commercials that match the one or more selections from among the plurality of advertising options may be output for presentation during a first commercial break in the television program.

Abstract: Arrangements for preparing a television channel for presentation are presented. A tuner of a television receiver may tune to a first television channel and the first television channel may be output for presentation. One or more idle tuners of the television receiver may be identified. One or more television channels other than the first television channel may be selected for preparation. The one or more television channels may be selected prior to receiving user input selecting a television channel of the one or more television channels for presentation. Each of the one or more television channels may be prepared for presentation by tuning, by each tuner of the one or more idle tuners, to the one or more television channels prior to receiving the user input selecting the television channel of the one or more television channels for presentation.

Abstract: Techniques are disclosed for capturing, transcoding, and caching off-air programming at a location local to the consumer. According to certain embodiments, a device is provided that receives off-air (e.g., broadcast) and/or cable (e.g. ClearQAM) programming via one or more antennas and caches the programming in various streams having various bit rates for later viewing using, for example, Adaptive Bit Rate (ABR) streaming. Such a device can be incorporated in a larger system that can stream content via a data communication network (e.g., the Internet) and the device in a seamless manner. The device also can be controlled by a remote system via the data communication network, and further can be configured to stream content to a remote device via the data communication network.