Patents by Inventor David L. Beeler

David L. Beeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-0-SULFATED POLYSACCHARIDES AND METHODS OF PREPARATION THEREOF
    Publication number: 20120202706
    Abstract: Disclosed are methods of 6-O sulfating glucosaminyl N-acetylglucosamine residues (GlcNAc) in a polysaccharide preparation and methods of converting anticoagulant-inactive heparan sulfate to anticoagulant-active heparan sulfate and substantially pure polysaccharide preparations made by such methods. Also disclosed is a mutant CHO cell which hyper-produces anticoagulant-active heparan sulfate. Methods for elucidating the sequence of activity of enzymes in a biosynthetic pathway are provided.
    Type: Application
    Filed: November 29, 2011
    Publication date: August 9, 2012
    Inventors: Robert D. Rosenberg, Lijuan Zhang, David L. Beeler
  • 6-O sulfated polysaccharides and methods of preparation thereof
    Patent number: 8067196
    Abstract: Disclosed are methods of 6-O-sulfating glucosaminyl N-acetylglucosamine residues (GlcNAc) in a polysaccharide preparation and methods of converting anticoagulant-inactive heparan sulfate to anticoagulant-active heparan sulfate and substantially pure polysaccharide preparations may by such methods. Also disclosed is a mutant CHO cell which hyper-produces anticoagulant-active heparan sulfate. Methods for elucidating the sequence of activity of enzymes in a biosynthetic pathway are provided.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: November 29, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert D. Rosenberg, Lijuan Zhang, David L. Beeler
  • Methods of 6-0 sulfating polysaccharides and 6-0 sulfated polysaccharide preparations
    Publication number: 20040191870
    Abstract: Disclosed are methods of 6-O-sulfating glucosaminyl N-acetylglucosamine residues (GlcNAc) in a polysaccharide preparation and methods of converting anticoagulant-inactive heparan sulfate to anticoagulant-active heparan sulfate and substantially pure polysaccharide preparations may by such methods. Also disclosed is a mutant CHO cell which hyper-produces anticoagulant-active heparan sulfate. Methods for elucidating the sequence of activity of enzymes in a biosynthetic pathway are provided.
    Type: Application
    Filed: March 25, 2004
    Publication date: September 30, 2004
    Inventors: Robert Rosenberg, Lijuan Zhang, David L Beeler