Patents by Inventor David L. Brown

David L. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200085811
    Abstract: A method of treating or preventing a neuroinflammatory and/or neurodegenerative disease in a subject by administering a pharmaceutically effective amount of a CB2 receptor agonist is described. The CB2 receptor agonist can be a compound according to formula I or a pharmaceutically acceptable salt thereof, with R1 and R2 as defined herein. Administration of the CB2 receptor agonist activates CB2 receptors in the microglia, can restore syntaptic plasticity, cognition, and memory in subjects having elevated levels of amyloid-?peptide in the brain.
    Type: Application
    Filed: November 22, 2019
    Publication date: March 19, 2020
    Inventors: Mohamed Naguib Attala, David L. Brown
  • Publication number: 20200090732
    Abstract: A memory device includes a data write circuitry. The data write circuitry is configured to capture a first write command received via an external input/output (I/O) interface. The data write circuitry is further configured to generate a first internal write start (InternalWrStart) in a data strobe (DQS) domain after capture of the first write command. The data write circuitry is additionally configured to write a first one or more data bits into at least one memory bank based on the first InternalWrStart, wherein the first InternalWrStart is generated internally in the memory device.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 19, 2020
    Inventors: Daniel B. Penney, David R. Brown, Gary L. Howe
  • Publication number: 20200081629
    Abstract: Provided are techniques for performing a recovery copy command to restore a safeguarded copy backup to a production volume. In response to receiving a recovery copy command, a production target data structure is created. A read operation is received for data for a storage location. In response to determining that the data for the storage location is in a cache of a host and a generation number is greater than a recovery generation number, the data is read from the cache. In response to determining at least one of that the data for the storage location is not in the cache and that the generation number is not greater than the recovery generation number, the data is read from one of the production volume and a backup volume based on a value of an indicator for the storage location in the production target data structure.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 12, 2020
    Inventors: Theresa M. Brown, Nedlaya Y. Francisco, Nicolas M. Clayton, Mark L. Lipets, Carol S. Mellgren, Gregory E. McBride, David Fei, Kevin Lin
  • Publication number: 20200066418
    Abstract: A system for producing and harvesting radioisotopes is provided, the system having a converter housing defining a first beam window; a converter carrier and cartridge in slidable communication with the converter housing; a target housing positioned downstream from the converter housing, the target housing defining a second beam window; and a target carrier in slidable communication with the target housing.
    Type: Application
    Filed: August 27, 2018
    Publication date: February 27, 2020
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: David A. Rotsch, Nicholas A. Smith, David A. Ehst, Sergey A. Chemerisov, Jerry A. Nolen, JR., Michael Alexander Brown, James J. Grudzinski, James L. Bailey, Ronald T. Kmak
  • Patent number: 10564159
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: February 18, 2020
    Assignee: Diagnostic Hybrids, Inc.
    Inventors: Leonard Kohn, James L. Brown, David R. Scholl, Yunsheng Li, Giorgio Napolitano
  • Patent number: 10562809
    Abstract: A low K value, high Q value, low firing dielectric material and method of forming a fired dielectric material. The dielectric material can be fired below 950° C. or below 1100° C., has a K value of less than about 8 at 10-30 GHz and a Q value of greater than 500 or greater than 1000 at 10-30 GHz. The dielectric material includes, before firing a solids portion including 10-95 wt % or 10-99 wt % silica powder and 5-90 wt % or 1-90 wt % glass component. The glass component includes 50-90 mole % SiO2, 5-35 mole % or 0.1-35 mole % B2O3, 0.1-10 mole % or 0.1-25 mole % Al2O3, 0.1-10 mole % K2O, 0.1-10 mole % Na2O, 0.1-20 mole % Li2O, 0.1-30 mole % F. The total amount of Li2O+Na2O+K2O is 0.1-30 mole % of the glass component. The silica powder can be amorphous or crystalline.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: February 18, 2020
    Assignee: Ferro Corporation
    Inventors: Cody J. Gleason, John J. Maloney, Srinivasan Sridharan, George E. Sakoske, Peter Marley, Mohammed H. Megherhi, Yie-Shein Her, Orville W. Brown, Jackie D. Davis, Thomas J. Coffey, Ellen S. Tormey, Stanley Wang, David L. Widlewski
  • Publication number: 20200042264
    Abstract: Aspects of the subject technology relate to electronic device display circuitry and methods of operating the display. The display circuitry a panel driver interface that decodes digital display data, for each display frame, received from host circuitry of the electronic device. The digital display data includes error correction and detection information for frame and line configuration information distributed in a frame packet and multiple line packets for each display frame. The frame and line configuration information facilitates, efficient, low-error, digital control of various display operational features.
    Type: Application
    Filed: August 1, 2019
    Publication date: February 6, 2020
    Inventors: Fenghua Zheng, David S. Zalatimo, James E. Brown, Sachiko Oda, Johan L. Piper
  • Publication number: 20200042991
    Abstract: Techniques to perform mathematically and logically rigorous validations for decentralized applications (DApp) communicatively coupled to a distributed ledger are disclosed. A protocol for a business or enterprise process is encoded as a workflow on a labeled transition system as part of a DApp. Transitions are coded via an asynchronous Pi Calculus or other process calculi. A rules engine validates transitions using process calculi operations, or alternatively performing mathematical and logical analyses on the labeled transition system. Validations are disclosed for both development time and run time. In some embodiments, the logic behind the DApp is composed of a predetermined set of components representing processes. In one specific embodiment, the predetermined set of components is solely of an input component and an output component when composed perform a transaction where either both components received artifact representations from the other component or neither do.
    Type: Application
    Filed: July 30, 2019
    Publication date: February 6, 2020
    Inventors: Allen L. BROWN, JR., David B. EZELL, Patrick J.D. SANTOS
  • Publication number: 20200024996
    Abstract: A vane stage segment is provided including an outer wall segment, an inner wall segment, and an airfoil. The outer wall segment is configured to be coupled to other outer wall segments to form an outer wall of the vane stage. The inner wall segment is spaced radially inward from the outer wall segment. At least one of the inner wall segment or the outer wall segment is separable between a forward portion and an aft portion. The airfoil extends between the outer wall segment and the inner wall segment.
    Type: Application
    Filed: July 17, 2018
    Publication date: January 23, 2020
    Applicant: Rolls-Royce Corporation
    Inventors: Elise A. M. Brown, Emma L. Mitchell, Elyse M. McMillen, David L. Tondreau, III, Eric T. Koenig, Linnea L. Taketa
  • Publication number: 20190386054
    Abstract: An image sensor for electrons or short-wavelength light includes a semiconductor membrane, circuit elements formed on one surface of the semiconductor membrane, and a pure boron layer on the other surface of the semiconductor membrane. The circuit elements are connected by metal interconnects comprising a refractory metal. An anti-reflection or protective layer may be formed on top of the pure boron layer. This image sensor has high efficiency and good stability even under continuous use at high flux for multiple years. The image sensor may be fabricated using CCD (charge coupled device) or CMOS (complementary metal oxide semiconductor) technology. The image sensor may be a two-dimensional area sensor, or a one-dimensional array sensor.
    Type: Application
    Filed: May 23, 2019
    Publication date: December 19, 2019
    Inventors: Yung-Ho Alex Chuang, Jingling Zhang, John Fielden, David L. Brown, Masaharu Muramatsu, Yasuhito Yoneta, Shinya Otsuka
  • Patent number: 10510398
    Abstract: A memory device includes a data write circuitry. The data write circuitry is configured to capture a first write command received via an external input/output (I/O) interface. The data write circuitry is further configured to generate a first internal write start (InternalWrStart) in a data strobe (DQS) domain after capture of the first write command. The data write circuitry is additionally configured to write a first one or more data bits into at least one memory bank based on the first InternalWrStart, wherein the first InternalWrStart is generated internally in the memory device.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: December 17, 2019
    Assignee: Micron Technology, Inc.
    Inventors: Daniel B. Penney, David R. Brown, Gary L. Howe
  • Publication number: 20190359899
    Abstract: Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventors: Benjamin S. UMANSKY, Himanshu GUPTA, John D. NELSON, Cindy J. HUGHART, Jane C. CHENG, Steven W. LEVINE, Stephen H. BROWN, Todd P. MARUT, David C. DANKWORTH, Stuart L. SOLED, Thomas F. DEGNAN, JR., Robert J. FALKINER, Mohsen N. HARANDI, Juan D. HENAO, Lei ZHANG, Chuansheng BAI, Richard C. DOUGHERTY
  • Publication number: 20190338203
    Abstract: Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude.
    Type: Application
    Filed: July 16, 2019
    Publication date: November 7, 2019
    Inventors: Benjamin S. UMANSKY, Himanshu GUPTA, John D. NELSON, Cindy J. HUGHART, Jane C. CHENG, Steven W. LEVINE, Stephen H. BROWN, Todd P. MARUT, David C. DANKWORTH, Stuart L. SOLED, Thomas F. DEGNAN, JR., Robert J. FALKINER, Mohsen N. HARANDI, Juan D. HENAO, Lei ZHANG, Chuansheng BAI, Richard C. DOUGHERTY
  • Patent number: 10469782
    Abstract: A time delay and integration charge coupled device includes an array of pixels and a clock generator. The array of pixels is distributed in a scan direction and a line direction perpendicular to the scan direction in which at least some of the pixels of the array include three or more gates aligned in the scan direction. The clock generator provides clocking signals to transfer charge along the scan direction between two or more pixel groups including two or more pixels adjacent in the scan direction. The clocking signals include phase signals to transfer the charge to an adjacent pixel group along the scan direction at a rate corresponding to the velocity of the target by driving the gates of the two or more pixel groups and generating a common potential well per pixel group for containing charge generated in response to incident illumination.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: November 5, 2019
    Assignee: KLA-Tencor Corporation
    Inventor: David L. Brown
  • Patent number: 10466212
    Abstract: A scanning electron microscope incorporates a multi-pixel solid-state electron detector. The multi-pixel solid-state detector may detect back-scattered and/or secondary electrons. The multi-pixel solid-state detector may incorporate analog-to-digital converters and other circuits. The multi-pixel solid state detector may be capable of approximately determining the energy of incident electrons and/or may contain circuits for processing or analyzing the electron signals. The multi-pixel solid state detector is suitable for high-speed operation such as at a speed of about 100 MHz or higher. The scanning electron microscope may be used for reviewing, inspecting or measuring a sample such as unpatterned semiconductor wafer, a patterned semiconductor wafer, a reticle or a photomask. A method of reviewing or inspecting a sample is also described.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: November 5, 2019
    Assignee: KLA—Tencor Corporation
    Inventors: David L. Brown, Yung-Ho Alex Chuang, John Fielden, Marcel Trimpl, Jingjing Zhang, Devis Contarato, Venkatraman Iyer
  • Patent number: 10462391
    Abstract: An inspection system and methods in which analog image data values (charges) captured by an image sensor are binned (combined) before or while being transmitted as output signals on the image sensor's output sensing nodes (floating diffusions), and in which an ADC is controlled to sequentially generate multiple corresponding digital image data values between each reset of the output sensing nodes. According to an output binning method, the image sensor is driven to sequentially transfer multiple charges onto the output sensing nodes between each reset, and the ADC is controlled to convert the incrementally increasing output signal after each charge is transferred onto the output sensing node. According to a multi-sampling method, multiple charges are vertically or horizontally binned (summed/combined) before being transferred onto the output sensing node, and the ADC samples each corresponding output signal multiple times. The output binning and multi-sampling methods may be combined.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: October 29, 2019
    Assignee: KLA-Tencor Corporation
    Inventors: Yung-Ho Alex Chuang, David L. Brown, Devis Contarato, John Fielden, Daniel I. Kavaldjiev, Guoheng Zhao, Jehn-Huar Chern, Guowu Zheng, Donald W. Pettibone, Stephen Biellak
  • Patent number: 10455533
    Abstract: A system and method for wireless synchronization on a network are disclosed. In one embodiment, the wireless device includes a wireless transceiver and processing circuitry. The wireless transceiver wirelessly receives synchronization information including a superframe from a first wireless, reader device, and wirelessly transmits the synchronization information to a second wireless, reader device and a portable wireless device, and to wirelessly detect a presence of a portable wireless device. The processing circuitry communicates synchronization information to the second wireless, reader device and portable wireless device. The superframe is used to synchronize a wireless data exchange between the third wireless, reader device and the portable wireless device.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: October 22, 2019
    Assignee: Proxense, LLC
    Inventor: David L. Brown
  • Patent number: 10446696
    Abstract: An inspection system including an optical system (optics) to direct light from an illumination source to a sample, and to direct light reflected/scattered from the sample to one or more image sensors. At least one image sensor of the system is formed on a semiconductor membrane including an epitaxial layer having opposing surfaces, with circuit elements formed on one surface of the epitaxial layer, and a pure boron layer and a doped layer on the other surface of the epitaxial layer. The image sensor may be fabricated using CCD (charge coupled device) or CMOS (complementary metal oxide semiconductor) technology. The image sensor may be a two-dimensional area sensor, or a one-dimensional array sensor. The image sensor can be included in an electron-bombarded image sensor and/or in an inspection system.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: October 15, 2019
    Assignee: KLA-Tencor Corporation
    Inventors: Jehn-Huar Chern, Ali R. Ehsani, Gildardo Delgado, David L. Brown, Yung-Ho Alex Chuang, John Fielden
  • Publication number: 20190313044
    Abstract: A multiple-column-per-channel image CCD sensor utilizes a multiple-column-per-channel readout circuit including connected transfer gates that alternately transfer pixel data (charges) from a group of adjacent pixel columns to a shared output circuit at high speed with low noise. Charges transferred along the adjacent pixel columns at a line clock rate are alternately passed by the transfer gates to a summing gate that is operated at multiple times the line clock rate to pass the image charges to the shared output circuit. A symmetrical fork-shaped diffusion is utilized in one embodiment to merge the image charges from the group of related pixel columns. A method of driving the multiple-column-per-channel CCD sensor with line clock synchronization is also described. A method of inspecting a sample using the multiple-column-per-channel CCD sensor is also described.
    Type: Application
    Filed: June 12, 2019
    Publication date: October 10, 2019
    Inventors: Yung-Ho Alex Chuang, Jingjing Zhang, Sharon Zamek, John Fielden, Devis Contarato, David L. Brown
  • Patent number: D879479
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: March 31, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Connor M. Pelletier-Sutton, Lisa M. Miller, Tracie J. Berniard, Lindsay J. Schostag, Jennifer A. Higgins, Flor T. Frey, Andrew P. Singer, Daniel J. Hoyord, David K. Bruechert, Mary L. Brown, Jeffrey D. Swenson