Patents by Inventor David L. Coffen

David L. Coffen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lower-alkyl or aryl-sulfonyl unsaturated tacopherols
    Patent number: 4882441
    Abstract: A process for producing natural vitamin E and intermediates in this process.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: November 21, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David L. Coffen, Rudolf Schmid, Mark J. Sebastian
  • Vitamin E intermediate
    Patent number: 4879395
    Abstract: A process for producing natural vitamin E and intermediates in this process.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: November 7, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David L. Coffen, Rudolf Schmid, Mark J. Sebastian
  • Prostaglandin intermediates
    Patent number: 4866205
    Abstract: New optically active intermediates and processes thereto are provided for use in synthesizing therapeutically active prostaglandins of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; from a compound of the formula: ##STR2## wherein R.sup.1 is as above and R.sup.2 is hydrogen or a carboxy blocking group convertible to an acid by hydrolysis.
    Type: Grant
    Filed: July 11, 1988
    Date of Patent: September 12, 1989
    Assignees: Hoffman-La Roche Inc., Hoffman-La Roche Inc.
    Inventors: David L. Coffen, George W. Holland, W. Harry Mandeville, Perry Rosen, Frederick Wong
  • Vitamin E intermediates
    Patent number: 4853472
    Abstract: A process for producing natural vitamin E and intermediates in this process.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: August 1, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David L. Coffen, Rudolf Schmid, Mark J. Sebastian
  • 2-(trimethyl-tridecenyl)-tetramethylchroman intermediates for vitamin E
    Patent number: 4789750
    Abstract: 6-Etherified hydroxy -2-(4',8',12'-trimethyl-5'-tridecenyl)-2,5,7,8-tetramethylchromans with an oxo or hydroxy substituent at the 2' position which may be substituted with an arylsulfonyl or a carboxyalkyl at the 3' position and containing a single or double bond at the 11 position, said chromans being intermediates for producing natural vitamin E.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: December 6, 1988
    Assignee: Hoffman-La Roche Inc.
    Inventors: David L. Coffen, Rudolf Schmid, Mark J. Sebastian
  • Prostaglandin intermediates
    Patent number: 4707555
    Abstract: New optically active intermediates and processes thereto are provided for use in synthesizing therapeutically active prostaglandins of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; from a compound of the formula: ##STR2## wherein R.sup.1 is as above and R.sup.2 is hydrogen or a carboxy blocking group convertible to an acid by hydrolysis.
    Type: Grant
    Filed: July 12, 1985
    Date of Patent: November 17, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David L. Coffen, George W. Holland, W. Harry Mandeville, Perry Rosen, Frederick Wong
  • Cyclopenta[b]furan-2-ones
    Patent number: 4558140
    Abstract: New optically active intermediates and processes thereto are provided for use in synthesizing therapeutically active prostaglandins of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; from a compound of the formula: ##STR2## wherein R.sup.1 is as above and R.sup.2 is hydrogen or a carboxy blocking group convertible to an acid by hydrolysis.
    Type: Grant
    Filed: March 6, 1984
    Date of Patent: December 10, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David L. Coffen, George W. Holland, Perry Rosen, Frederick Wong
  • Process for bicyclic diketones
    Patent number: 4495354
    Abstract: The preparation of bicyclic diketones of the formula ##STR1## wherein R.sub.1 is lower alkyl or ar-lower alkyl from a compound of the formula ##STR2## wherein R.sub.1 is as previously described or a salt thereof, and a di-lower alkyl malonate is described. The reactants are combined in a reaction sequence consisting of Michael addition, cyclization, hydrolysis, and decarboxylation. The preparation of the compounds of formula II is also described.
    Type: Grant
    Filed: March 29, 1982
    Date of Patent: January 22, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David L. Coffen, Urs O. Hengartner
  • Preparation of diketones
    Patent number: 4483990
    Abstract: The preparation of bicyclic diketones of the formula ##STR1## wherein R.sub.1 is lower alkyl or ar-lower alkyl, from compounds of the formula ##STR2## wherein R.sub.1 is as set forth above, is described.
    Type: Grant
    Filed: March 29, 1982
    Date of Patent: November 20, 1984
    Assignee: Hoffman-La Roche Inc.
    Inventor: David L. Coffen
  • Preservation of aqueous systems with 2-chloro-3-oxobutyramide derivatives
    Patent number: 4247712
    Abstract: There is disclosed methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of a 2-chloro-3-oxobutyramide derivative.
    Type: Grant
    Filed: November 8, 1979
    Date of Patent: January 27, 1981
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Preservation of aqueous systems with .alpha.-chloro-.beta.-aminocrotonamide
    Patent number: 4217363
    Abstract: Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of .alpha.-chloro-.beta.-aminocrotonamide.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: August 12, 1980
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Preservation of aqueous systems with 2-chloro-3-oxobutyramide derivatives
    Patent number: 4214002
    Abstract: There is disclosed methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of a 2-chloro-3-oxobutyramide derivative.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: July 22, 1980
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Novel 4-phenoxy-5-sulfamylbenzoic acid
    Patent number: 4208535
    Abstract: Novel 3-(butylamino) or (1-pyrrolidinyl)-4-phenoxy-5-sulfamylbenzoic acid derivatives where the butyl group contains either a double bond or a hydroxy, ketone, acid or ester functional group or groups, said compounds being useful as diuretics.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: June 17, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: David L. Coffen
  • Preservation of aqueous systems with .alpha.-bromo-.beta.-aminocrotononitrile
    Patent number: 4206229
    Abstract: Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of .alpha.-bromo-.beta.-aminocrotononitrile.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: June 3, 1980
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Preservation of aqueous systems with .alpha.-halo-.beta.-aminocrotonic acid esters
    Patent number: 4199600
    Abstract: Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of an .alpha.-halo-.beta.-aminocrotonic acid ester.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: April 22, 1980
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen