Patents by Inventor David L'Hostis

David L'Hostis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250146341
    Abstract: A separable mounting hinge device including two detachably engageable leaf hinge members wherein the first hinge member includes at least two knuckles affixed around a pin leaving at least one open knuckle seat therebetween. The second hinge member includes at least one open knuckle capable of operationally engaging around the pin and at least one leaf-knuckle protrusion. The second hinge member may also include a retention member. These hinge members' knuckle(s) and affixed pin open knuckle seat(s) operationally interlock thereby allowing for typical hinge movements, while detachment of said members simply requires the application of force within specifically designated angular ranges to overcome the protrusion, and potentially included retention member. As designed, the separable mounting hinge device minimizes the likelihood of any incidental or accidental detachment and obviates the need to unfasten at least one hinge from a door, panel, or frame only to refasten it later.
    Type: Application
    Filed: November 7, 2023
    Publication date: May 8, 2025
    Applicant: BFM INTERESTS, LLC
    Inventor: David L. BIGGERSTAFF
  • Publication number: 20250145465
    Abstract: The present disclosure describes a method of separating a carbon allotrope from a salt and a separation system for the same. The method may include adding a solid comprising the carbon allotrope and the salt to a solution comprising the salt, performing a first filtration on the solution at a first temperature to remove the carbon allotrope from the solution, adjusting the temperature of the solution to a second temperature to precipitate a first portion of the salt, performing a second filtration on the solution at the second temperature to remove the first portion of the salt from the solution, adjusting the temperature of the solution to the first temperature to dissolve a second portion of the salt in the solution, and recycling the solution.
    Type: Application
    Filed: November 8, 2023
    Publication date: May 8, 2025
    Applicant: SkyNano LLC
    Inventors: James O'MALLEY, David L. WOOD, III, Anna E. DOUGLAS, Lucy MOORE
  • Publication number: 20250143325
    Abstract: The present invention provides a composition including a mixture of essential oils and terpene alcohol. The present invention also provides an article containing a composition comprising a mixture of essential oils and terpene alcohol. The present invention further provides a method of preparing a composition comprising a mixture of essential oils and terpene alcohol.
    Type: Application
    Filed: October 23, 2024
    Publication date: May 8, 2025
    Inventors: Eric Rubel, David L. Lowe, Lawrence E. Bradford
  • Publication number: 20250144052
    Abstract: Disclosed herein is a multidrug pain management package to dispense two or more medicaments to treat pain comprising a primary n-polygon, and one or more concentric m-polygons, wherein each side of the n-polygon and m-polygons have at least n or m-medicament chambers capable of holding the two or more medicaments. Also disclosed herein is a multidrug pain management package comprising a disk, wherein the disk is divided into equally spaced regions, and wherein each region has chambers capable of holding medicaments. Also disclosed herein are single formulations to treat pain.
    Type: Application
    Filed: January 10, 2025
    Publication date: May 8, 2025
    Inventors: David L. STEINBERG, Joseph LOSKOVE, Hannah THOMPSON
  • Publication number: 20250143759
    Abstract: A patella fracture fixation system includes a peripheral rim bone plate that is configured to be implanted along a parapatellar lateral approach. The bone plate can configured to minimize disruption of blood supply to the patella. The bone plate can be augmented with a Krackow suture pattern to assist in stabilization of a comminuted inferior pole.
    Type: Application
    Filed: January 10, 2025
    Publication date: May 8, 2025
    Inventors: David L. Helfet, Dean G. Lorich
  • Publication number: 20250145486
    Abstract: The present disclosure describes a contactor device which may include a housing including a tank and a lid, wherein there is a seal between the tank and the lid, at least one liquid inlet, at least one gas inlet, a bed of a contact medium contained within the tank and positioned over a barrier having a plurality of through holes, at least one liquid outlet, at least one gas outlet, and a guide plate positioned to prevent the liquid from reaching the gas outlet. Methods of operating a contactor device are also described and may include methods of capturing and converting carbon dioxide to commercially useful materials.
    Type: Application
    Filed: November 3, 2023
    Publication date: May 8, 2025
    Applicant: SkyNano LLC
    Inventors: David L. WOOD, III, James O'MALLEY, Anna E. DOUGLAS
  • Patent number: 12290354
    Abstract: Methods of compensating for ambient temperature using temperature sensors, the method comprising: sampling at a first sampling rate, with a processor, first temperature measurements from a first temperature sensor on an on-body sensor. Then determining, with a processor, first ambient-compensated temperatures from the first temperature measurements; and determining, with a processor, final ambient-compensated temperatures by applying a correction gain or factor to the first ambient-compensated temperatures. Wherein the correction gain or factor changes value at a slower rate than the sampling rate.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: May 6, 2025
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Gary A. Hayter, Daniel M. Bernstein, Martin J. Fennell, Michael R. Love, Kenneth J. Doniger, Songbiao Zhang, Mark K. Sloan, Hyun Cho, Theodore J. Kunich, Jean-Pierre Cole, Christopher A. Thomas, Erwin S. Budiman, David L. Li, Royce Cheng, Udo Hoss
  • Patent number: 12290061
    Abstract: An insect repellant device including a repellant portion and a light portion with a simulated flame and constant light option.
    Type: Grant
    Filed: April 17, 2024
    Date of Patent: May 6, 2025
    Assignee: PIC Corporation
    Inventors: Eric Rubel, David L. Lowe, Lawrence E. Bradford
  • Patent number: 12291538
    Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, Cy, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.
    Type: Grant
    Filed: May 3, 2023
    Date of Patent: May 6, 2025
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Indu Bharathan, Symon Gathiaka, Yongxin Han, Xiaoshen Ma, Ryan D. Otte, David L. Sloman, Thomas H. Graham, Timothy Henderson, Elisabeth Hennessy, Anandan Palani
  • Patent number: 12291990
    Abstract: Internal combustion engines, including engines producing power from solid or slow burning fuel(s), such as biological-based or petroleum-based fuels, wood, corn, biomass, coal, and waste products, and/or possibly other liquid or gaseous fluids, as well as methods for operating or implementing such engines, are disclosed herein. In an example embodiment, the engine includes a crankshaft, a piston, a cylinder having an internal cavity and several ports, and an assembly having a chamber having a first region within which solid fuel can be situated and combusted. The assembly further includes a diverter valve so that, depending upon a setting of the valve and during engine operation, first and second amounts of compressed air respectively proceed to the first region and to bypass the first region, and a combination of combustion products and the second amount proceeds via one of the ports to the part of the internal cavity.
    Type: Grant
    Filed: July 25, 2023
    Date of Patent: May 6, 2025
    Inventor: David L. Stenz
  • Publication number: 20250136907
    Abstract: Systems and methods for providing ex vivo approximation of micro- and/or nanoparticle oral toxicity in humans include an ex vivo human intestinal model organoid comprising an epithelial layer that separates an apical volume and a basal volume of the ex vivo human intestinal model organoid, a bioreactor for maintaining the ex vivo human intestinal model organoid under physiologically relevant culture conditions, a particle administration inlet adapted to receive a predefined quantity of micro- and/or nanoparticles and to introduce the predefined quantity to the apical volume of the ex vivo human intestinal model organoid according to a predefined dosing regimen, an analytical platform adapted to: interrogate the ex vivo human intestinal model organoid or associated culture media within the bioreactor, and/or to receive and interrogate the ex vivo human intestinal model organoid and/or the associated culture media after removal from the bioreactor, a processor, and a memory.
    Type: Application
    Filed: September 4, 2024
    Publication date: May 1, 2025
    Inventors: David L. Kaplan, Ying Chen
  • Patent number: 12285062
    Abstract: An air delivery system includes a visor having an outer peripheral edge and an inner peripheral edge. An air filtration assembly is removably mounted above an opening in the visor between the outer and inner peripheral edges, the air filtration assembly comprising a fan having an air inlet and an air outlet, an anode layer disposed over the air inlet, a filter layer disposed over the anode layer and a cathode layer disposed over the filter layer. In a first configuration, the air filtration assembly provides air flow toward an inner surface of the visor and, in a second configuration, the air filtration assembly provides air flow away from an outer surface of the visor. The air filtration assembly includes a mode actuator configured to control operation of a filtration mode indicator in dependence upon positioning of the air filtration assembly in the first or second configuration.
    Type: Grant
    Filed: April 14, 2022
    Date of Patent: April 29, 2025
    Assignee: EST OPTIMUM SUI LLC
    Inventors: James E. Vandendorpe, David L Vandendorpe
  • Patent number: 12285002
    Abstract: An insect repellant device including a repellant portion and a light portion with a simulated flame and constant light option.
    Type: Grant
    Filed: January 25, 2024
    Date of Patent: April 29, 2025
    Assignee: PIC Corporation
    Inventors: Eric Rubel, David L. Lowe, Lawrence E. Bradford
  • Patent number: 12287165
    Abstract: Disclosed is an extractor for an autoloading firearm, the extractor having an extractor body extending a proximal end portion to a distal end portion. A knuckle is between the proximal end portion and the distal end portion and defines a pin opening extending crosswise through the extractor, where the pin opening has an elongated shape. During rearward movement of the bolt after firing, the elongated opening enables the extractor to shift downward and/or forward so that part of the extractor contacts the bolt, thereby preventing the extractor from pivoting about the extractor pin.
    Type: Grant
    Filed: July 17, 2023
    Date of Patent: April 29, 2025
    Assignee: SIG SAUER, INC.
    Inventors: Lucas P. Gagne, Aaron C Sakash, Bryan C. Dustin, David L. Steimke
  • Patent number: 12285354
    Abstract: A fertility-enhancing cooling seat for lowering temperatures of human testicles so as to increase sperm quality and quantity. The cooling seat includes: a top flexible portion and a base portion; a bottom flexible portion coupled to the top flexible portion, the bottom flexible portion forming a seal with the base portion, portions of the bottom flexible portion and portions of the top flexible portion defining isolated cooling cells with cooling-cell volumetric spaces; a phase-change material located in the cooling-cell volumetric spaces, the phase-change material configured to change from a solid phase to a liquid phase at a first temperature and that is configured to change from a liquid phase to a solid phase at a second temperature that is lower than the first temperature. At least one of the isolated cooling cells defines a diameter that is larger than a diameter of the other of the cooling cells.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: April 29, 2025
    Inventors: David L. Abramson, Steven A. Pentelnik, Wendy L. Everett
  • Publication number: 20250129118
    Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
    Type: Application
    Filed: December 23, 2024
    Publication date: April 24, 2025
    Inventors: Robert J. GILLIES, David L. MORSE, Natalie M. BARKEY, Kevin N. SILL, Josef VAGNER, Narges K. TAFRESHI, Jonathan L. SESSLER, Christian PREIHS, Victor J. HRUBY
  • Patent number: 12280101
    Abstract: Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of the active agents upon storage and/or transportation. In some embodiments, the storage-stable vaccine-silk compositions are also provided herein.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: April 22, 2025
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto
  • Patent number: 12280038
    Abstract: Described herein are novel ?- and ?-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: April 22, 2025
    Assignees: The University of Chicago, IIT Research Institute
    Inventors: Michael J. Kates, Nanduri R. Prabhakar, David L. McCormick, Miguel Muzzio
  • Patent number: 12282714
    Abstract: A device includes one or more processors configured to generate simulation data by providing first sets of first values of first input parameters to a simulation of a physical system. The processors are configured to develop at least one surrogate model based on the simulation data, and to select second input parameters from the first input parameters based on the at least one surrogate model. A count of the second input parameters is less than a count of the first input parameters. The processors are configured to generate second simulation data by providing second sets of second values of the second input parameters to the simulation. The processors are configured to develop at least a second surrogate model based on the second simulation data.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: April 22, 2025
    Assignee: THE BOEING COMPANY
    Inventors: Kelsea Cox, Lindsay L. Jones, Caroline M. Kerfonta, Brittan A. Farmer, Richard J. Thompson, Marcus A. Bakke, E-June Chen, David L. Carlson
  • Patent number: D1072079
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: April 22, 2025
    Inventor: David L. Osment