Patents by Inventor David L. Ladd
David L. Ladd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7160924Abstract: The present invention broadly relates to the field of protein modification, and, more specifically, to conjugates of proteins or analogs thereof to a water-soluble biocompatible polymer and methods of making and using the same.Type: GrantFiled: July 18, 2003Date of Patent: January 9, 2007Assignees: The General Hospital Corporation, Amgen, Inc.Inventors: Olaf B. Kinstler, David L. Ladd, Mikahil I. Papisov
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Publication number: 20040105840Abstract: The present invention broadly relates to the field of protein modification, and, more specifically, to conjugates of proteins or analogs thereof to a water-soluble biocompatible polymer and methods of making and using the same.Type: ApplicationFiled: July 18, 2003Publication date: June 3, 2004Inventors: Olaf B. Kinstler, David L. Ladd, Mikahil I. Papisov
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Patent number: 6017522Abstract: A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said compisition having a molecular weight of at least 4,500; ##STR1## wherein: Z is a chelating residue;Q is a divalent poly(alkylene oxidylene) moiety having a carbon terminus at R and at L;L represents an amide linkage;E.sup.(b) is one or more counterions each having a charge of b;b is an integer from 1, 2 and 3;n is an integer selected from the group 1, 2, 3 and 4;w is zero or an integer from 1 to 5;M.sup.(+a) is a cation, having a charge of +a;a is an integer from 1 to 4;r is 0 or an integer from 1 to 3, provided that when r is 2-3, each M.sup.(+a) can be the same or different cation;d is the total charge on the chelating residue and is an integer from 0 to 10;d+.SIGMA.(b.multidot.w)+.SIGMA.(a.multidot.r)=O; andR is a capping moiety chosen from the group consisting of hydrogen, hydroxyl, C.sub.1 -C.sub.Type: GrantFiled: April 25, 1997Date of Patent: January 25, 2000Assignee: Sterling Winthrop Inc.Inventors: Dennis E. Butterfield, Dennis K. Fujii, David L. Ladd, Robert A. Snow, Julia S. Tan, John L. Toner
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Patent number: 5958372Abstract: Disclosed are linear and cross-linked polymers suitable for use as a contrast agent for magnetic resonance imaging containing units comprising the residue of a poly(amine) moiety linked to a chelating agent and to one or more pendant (poly)alkylene oxides.Type: GrantFiled: June 28, 1994Date of Patent: September 28, 1999Assignee: Nycomed Imaging ASInventor: David L. Ladd
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Patent number: 5932188Abstract: This invention provides therapeutic and diagnostic imaging compositions and methods featuring a polymer comprising units containing a poly(alkylene oxide) moiety linked to the residue of a chelating agent, said polymer having a cytotoxic agent associated therewith.Type: GrantFiled: October 28, 1997Date of Patent: August 3, 1999Assignee: Sterling Winthrop Inc.Inventors: Robert A. Snow, David L. Ladd, John L. Toner
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Patent number: 5817292Abstract: This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.Type: GrantFiled: October 14, 1992Date of Patent: October 6, 1998Assignee: Nycomed Imaging ASInventors: Robert A. Snow, David L. Ladd, John L. Toner
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Patent number: 5756688Abstract: This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.Type: GrantFiled: September 14, 1993Date of Patent: May 26, 1998Assignee: Sterling Winthrop Inc.Inventors: Robert A. Snow, David L. Ladd, John L. Toner, K. Robert Hollister
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Patent number: 5730968Abstract: A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said composition having a molecular weight of at least 4,500; ##STR1## wherein: Z is a chelating residue;Q is a divalent poly(alkylene oxidylene) moiety having a carbon terminus at R and at L;L represents an amide linkage;E.sup.(b) is one or more counterions each having a charge of b;b is an integer from 1, 2 and 3;n is an integer selected from the group 1, 2, 3 and 4;w is zero or an integer from 1 to 5;M.sup.(+a) is a cation, having a charge of +a;a is an integer from 1 to 4;r is 0 or an integer from 1 to 3, provided that when r is 2-3, each M.sup.(+a) can be the same or different cation;d is the total charge on the chelating residue and is an integer from 0 to 10;d+.SIGMA.(b.multidot.w)+.SIGMA.(a.multidot.r)=O; andR is a capping moiety chosen from the group consisting of hydrogen, hydroxyl, C.sub.1 -C.sub.Type: GrantFiled: March 31, 1994Date of Patent: March 24, 1998Assignee: Sterling Winthrop Inc.Inventors: Dennis E. Butterfield, Dennis K. Fujii, David L. Ladd, Robert A. Snow, Julia S. Tan, John L. Toner
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Patent number: 5661020Abstract: Disclosed are pharmaceutical compositions containing low diol polyethylene glycol, covalently attached to superoxide and dismutase process of making the compositions. Also disclosed is a method of treatment of disease processes associated with the adverse effects on tissue of superoxide anions, such as ischemic events, reperfusion injury, trauma and inflammation.Type: GrantFiled: April 15, 1996Date of Patent: August 26, 1997Assignee: SanofiInventors: Robert A. Snow, David L. Ladd, Denton W. Hoyer
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Patent number: 5583206Abstract: In accordance with this invention, there is provided a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, and a method for the preparation thereof. The polymer is particularly useful in therapeutic and diagnostic imaging compositions and as an antistatic agent.Type: GrantFiled: November 28, 1994Date of Patent: December 10, 1996Assignee: Sterling WinthropInventors: Robert A. Snow, David L. Ladd, John L. Toner
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Patent number: 5532150Abstract: Disclosed are pharmaceutical compositions containing low diol polyethylene glycol, covalently attached to superoxide and dismutase process of making the compositions. Also disclosed is a method of treatment of disease processes associated with the adverse effects on tissue of superoxide anions, such as ischemic events, reperfusion injury, trauma and inflammation.Type: GrantFiled: May 19, 1994Date of Patent: July 2, 1996Assignee: Sterling Winthrop, Inc.Inventors: Robert A. Snow, David L. Ladd, Denton W. Hoyer
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Patent number: 5476644Abstract: The present invention provides compounds of the formula ##STR1## chelated with a paramagnetic metal ion wherein Z1 and Z2 each represent the atoms necessary to complete a monocyclic or polycyclic carbocyclic or heterocyclic ring system, said Z1 and Z2 independently optionally substituted with R.sup.6 and R.sup.7, respectively;R.sup.l, R.sup.2, R.sup.3 and R.sup.4 are independently carboxyalkyl (C.sub.1 -C.sub.2), --(CH.sub.2).sub.n --C(.dbd.O)--NH--R.sup.8, or --(CH.sub.2).sub.n --C(.dbd.O)--O--R.sup.8R.sup.5 is carboxyalkyl (C.sub.1 -C.sub.2);R.sup.6 and R.sup.7 are independently hydrogen, benzyl, or benzyloxy, said benzyl or benzyloxy optionally substituted with one, two or three substituents selected from the group consisting of amino, isocyanato (--N.dbd.C.dbd.O), isothiocyanato (--N.dbd.C.dbd.S), --NH--C(.dbd.O)--X or --NH--C(.dbd.S)--X;R.sup.8 is alkyl (C.sub.1 -C.sub.20), --(CH.sub.2).sub.m --Ar, or polyhydroxyalkyl (C.sub.1 -C.sub.Type: GrantFiled: April 13, 1994Date of Patent: December 19, 1995Assignee: Sterling Winthrop Inc.Inventors: Carl R. Illig, Thomas J. Caulfield, John L. Toner, Peng Guo, David L. Ladd
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Patent number: 5414135Abstract: A new class of polyalkylene oxide vinyl sulfone reagents is described. Also described are a method by which these reagents can be prepared as well as a method for using them in hydrated media for the modification of proteins. The novel polymer-to-protein conjugates made by reacting these reagents with proteins have advantages over similar conjugates prepared with prior art reagents in that they are more stable against hydrolysis and retain the positive charge carrying capacity at amine sites at which the modifying reagents are attached.Type: GrantFiled: November 16, 1993Date of Patent: May 9, 1995Assignee: Sterling Winthrop Inc.Inventors: Robert A. Snow, David L. Ladd
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Patent number: 4482572Abstract: 1-Acylamino-1-cyclopentanecarboxylic acids have been prepared by acylation of certain 1-amino-1-cyclopentanecarboxylic acids and found to have renal vasodilating and diuretic properties.Type: GrantFiled: May 5, 1983Date of Patent: November 13, 1984Assignee: SmithKline Beckman CorporationInventors: David L. Ladd, Joseph Weinstock
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Patent number: 4336254Abstract: 2,4-Amino, guanidinopyrimidines have diuretic activity. A representative species of these compounds is 2-guanidino-4-amino-6-chloroguanidine which is prepared by the stepwise replacement of first the 2-halo of a 2,4,6-trihalopyrimidine by guanidino and then the 4-halo by ammonia.Type: GrantFiled: March 24, 1981Date of Patent: June 22, 1982Assignee: SmithKline CorporationInventor: David L. Ladd
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Patent number: 4336255Abstract: Pharmaceutical compositions having as active diuretic ingredients certain 4-guanidinopyridines are described. Representative diuretic compounds are 5-amino-6-chloro-4-guanidinopyrimidine and 6-amino-5-nitro-4-guanidinopyrimidine.Type: GrantFiled: March 24, 1981Date of Patent: June 22, 1982Assignee: SmithKline CorporationInventor: David L. Ladd
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Patent number: 3983245Abstract: The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of angina pectoris.Type: GrantFiled: February 6, 1975Date of Patent: September 28, 1976Assignee: SmithKline CorporationInventors: David L. Ladd, Stephen T. Ross