Patents by Inventor David L. Larson
David L. Larson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240158837Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.Type: ApplicationFiled: October 17, 2023Publication date: May 16, 2024Applicant: Juno Therapeutics, Inc.Inventors: Mark L. BONYHADI, David G. KUGLER, Timothy G. JOHNSTONE, Ronald James HAUSE, Jr., Lucas J. THOMPSON, Ryan P. LARSON
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Publication number: 20240110116Abstract: A process of making a fuel product as an additive from a non-auto-combustible high protein organic material for the destruction of polyfluoro compounds in a thermal process system is provided. Thermal reactions within thermal reaction equipment are controlled by controlling the moisture and oxygen in the reaction atmosphere of the equipment and energy inputs at or downstream of a thermal reaction chamber. The concentration of protein thermal decomposition by-products, temperature, and residence time and/or additions of energy within the thermal reaction equipment environment are controlled to destroy hazardous polyfluoro compounds.Type: ApplicationFiled: October 20, 2023Publication date: April 4, 2024Applicant: AKBEV GROUP, LLCInventors: Geoffrey L. Larson, Curtis Holmes, Brandon Michael Smith, David D. Wilson
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Patent number: 4994457Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as piroxicam, or a pharmaceutically acceptable salt thereof, with 5'-guanylic acid or N-acetyl-L-methionine, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 19, 1987Date of Patent: February 19, 1991Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, David L. Larson, Joseph G. Lombardino
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Patent number: 4960242Abstract: An asphalt distributor has a spray bar assembly that includes at least one extendable and retractable spray bar section for extending the overall width of the spray bar assembly beyond the lateral sides of a vehicle supporting the assembly. The extendable and retractable section includes a manifold tube that carries the asphalt to be sprayed, and which tube is in turn supported on a hydraulic actuator that is used for extending and retracting the associated manifold tube. The manifold tube is provided with a plurality of spray valve assemblies that are operated in a way so that the valves are turned on to permit spraying automatically as the spray bar manifold is extended laterally outwardly, and turn off the spray for the respective valve assembly as the manifold tube is retracted.Type: GrantFiled: July 28, 1988Date of Patent: October 2, 1990Assignee: Rosco Manufacturing CompanyInventor: David L. Larson
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Patent number: 4874757Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.Type: GrantFiled: November 4, 1988Date of Patent: October 17, 1989Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
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Patent number: 4812455Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilzer diazepam, or antihypertensive trimazosin.Type: GrantFiled: April 11, 1988Date of Patent: March 14, 1989Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
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Patent number: 4766117Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.Type: GrantFiled: December 12, 1986Date of Patent: August 23, 1988Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
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Patent number: 4672061Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesis acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.Type: GrantFiled: January 21, 1986Date of Patent: June 9, 1987Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
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Patent number: 4591595Abstract: 2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole and 2-(N-pentyl-N'-guanidino)-4-(2-methyl-4-imidazolyl)thiazole, histamine-H.sub.2 antagonist useful as a gastric acid antisecretory and antiulcer agents, are also useful per se in the treatment of rheumatoid arthritis.Type: GrantFiled: August 9, 1985Date of Patent: May 27, 1986Assignee: Pfizer Inc.Inventor: David L. Larson
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Patent number: 4579846Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.Type: GrantFiled: January 28, 1985Date of Patent: April 1, 1986Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
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Patent number: 4564614Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as piroxicam, or a pharmaceutically acceptable salt thereof, with pyridoxine.Type: GrantFiled: January 28, 1985Date of Patent: January 14, 1986Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
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Patent number: 4559326Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as prioxicam, or a pharmaceutically acceptable salt thereof, with inositol.Type: GrantFiled: January 31, 1985Date of Patent: December 17, 1985Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
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Patent number: 4543414Abstract: 2-Substituted-2-oxazolines are prepared by contacting N-(2-hydroxyalkyl)carboxamides with a small but catalytic amount of a cadmium or zinc salt at an elevated temperature.Type: GrantFiled: August 14, 1980Date of Patent: September 24, 1985Assignee: The Dow Chemical CompanyInventor: David L. Larson
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Patent number: 4354029Abstract: 2-Substituted-2-oxazolines are prepared by contacting N-(2-hydroxyalkyl)carboxamides with a small but catalytic amount of an organic zinc salt at an elevated temperature.Type: GrantFiled: November 30, 1981Date of Patent: October 12, 1982Assignee: The Dow Chemical CompanyInventors: Mark E. Kaiser, David L. Larson
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Patent number: 4352390Abstract: Partially devitrified silica cores with exceptional high temperature strength are disclosed for foundry use in sand casting of ferrous alloys. Precision cored holes of small size and long length, which heretofore could not be cast accurately or had to be machined because of limitations in existing core technology, are formed using accurately machined extruded porous silica cores fired to eliminate combustibles and partially devitrified (e.g., 15 to 30%) to develop a strong crystalline phase bond that resists viscous flow at a temperature of 1500.degree. C. and to increase the refractoriness of the vitreous silica grains, whereby the permeability and thermal shock resistance are such that the core can be heated very rapidly by molten steel to above 1500.degree. C. without spalling, cracking, sagging, breaking, or loss of integrity and without gas holes, scabs, fissures or other serious casting defects.Type: GrantFiled: September 12, 1980Date of Patent: October 5, 1982Assignee: Sherwood Refractories, Inc.Inventor: David L. Larson
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Patent number: 4236568Abstract: Partially devitrified silica cores with exceptional high temperature strength are disclosed for foundry use in sand casting of ferrous alloys. Precision cored holes of small size and long length, which heretofore could not be cast accurately or had to be machined because of limitations in existing core technology, are formed using accurately machined extruded porous silica cores fired to eliminate combustibles and partially devitrified (e.g., 15 to 30%) to develop a strong crystalline phase bond that resists viscous flow at a temperature of 1500.degree. C. and to increase the refractoriness of the vitreous silica grains, whereby the permeability and thermal shock resistance are such that the core can be heated very rapidly by molten steel to above 1500.degree. C. without spalling, cracking, sagging, breaking, or loss of integrity and without gas holes, scabs, fissures or other serious casting defects.Type: GrantFiled: December 4, 1978Date of Patent: December 2, 1980Assignee: Sherwood Refractories, Inc.Inventor: David L. Larson