Patents by Inventor David L. Meadows

David L. Meadows has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130296264
    Abstract: The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.
    Type: Application
    Filed: May 3, 2013
    Publication date: November 7, 2013
    Applicant: ALCON RESEARCH, LTD.
    Inventors: James W. Davis, Howard Allen Ketelson, Elaine E. Campbell, David L. Meadows, Rekha Rangarajan
  • Publication number: 20130244971
    Abstract: The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.
    Type: Application
    Filed: May 13, 2013
    Publication date: September 19, 2013
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
  • Patent number: 8536325
    Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: September 17, 2013
    Assignee: Alcon Research, Ltd.
    Inventors: James W. Davis, Howard Allen Ketelson, David L. Meadows, John C. Baker
  • Patent number: 8257745
    Abstract: The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic and otic pharmaceutical compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for ophthalmic and otic drugs. The nanoparticles may also be utilized to modify the rheological properties of the compositions, so as to enhance the viscosity or flow characteristics of the compositions and/or increase the retention time of the compositions in the eye or ear.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: September 4, 2012
    Assignee: Novartis AG
    Inventors: Howard Allen Ketelson, David L. Meadows
  • Publication number: 20120142630
    Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
    Type: Application
    Filed: February 14, 2012
    Publication date: June 7, 2012
    Applicant: ALCON RESEARCH, LTD.
    Inventors: James W. Davis, Howard Allen Ketelson, David L. Meadows, John C. Baker
  • Publication number: 20120070402
    Abstract: The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
    Type: Application
    Filed: November 22, 2011
    Publication date: March 22, 2012
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
  • Patent number: 8097270
    Abstract: The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for biocides. The nanoparticles are particularly useful in preventing or reducing the uptake of biocides from ophthalmic compositions by contact lenses, when the compositions are applied to the lenses.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: January 17, 2012
    Assignee: Novartis AG
    Inventors: Howard Allen Ketelson, Nissanke L. Dassanayake, Thomas Christopher Carey, David L. Meadows
  • Publication number: 20110274760
    Abstract: The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic and otic pharmaceutical compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for ophthalmic and otic drugs. The nanoparticles may also be utilized to modify the rheological properties of the compositions, so as to enhance the viscosity or flow characteristics of the compositions and/or increase the retention time of the compositions in the eye or ear.
    Type: Application
    Filed: July 19, 2011
    Publication date: November 10, 2011
    Inventors: Howard Allen Ketelson, David L. Meadows
  • Publication number: 20110275593
    Abstract: The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.
    Type: Application
    Filed: May 4, 2011
    Publication date: November 10, 2011
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
  • Publication number: 20110136912
    Abstract: The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
    Type: Application
    Filed: December 2, 2010
    Publication date: June 9, 2011
    Inventors: Howard Allen Ketelson, David L. Meadows
  • Publication number: 20110094295
    Abstract: Devices and methods for testing cement include: a pressure vessel with a sample container inside an interior working volume of the pressure vessel, the pressure vessel configured to supply a first pressurized fluid to control a pore pressure of a cement sample and to supply a second pressurized fluid to lateral exterior surfaces of the sample container to provide a confining pressure that can be different than the pore pressure.
    Type: Application
    Filed: October 28, 2009
    Publication date: April 28, 2011
    Applicant: HALLIBURTON ENERGY SERVICES, INC.
    Inventors: David L. Meadows, Robert P. Darbe, Keith D. Pewitt
  • Patent number: 7871602
    Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: January 18, 2011
    Assignee: Alcon, Inc.
    Inventors: Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows
  • Publication number: 20110008276
    Abstract: The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated.
    Type: Application
    Filed: July 7, 2010
    Publication date: January 13, 2011
    Applicant: ALCON RESEARCH, LTD.
    Inventors: James W. Davis, Howard Allen Ketelson, David L. Meadows
  • Publication number: 20100196415
    Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
    Type: Application
    Filed: February 5, 2010
    Publication date: August 5, 2010
    Applicant: ALCON RESEARCH, LTD.
    Inventors: James W. DAVIS, Howard Allen KETELSON, David L. MEADOWS, John C. BAKER
  • Publication number: 20100099771
    Abstract: Ophthalmic compositions containing very low concentrations (e.g., 1 to 50 ppm) of cooling agents are described. The cooling agents are less volatile and less prone to causing ocular discomfort than agents previously utilized to obtain an ocular cooling effect, such as menthol. The cooling agents are preferably contained in a vehicle that forms a gel or partial gel upon application to the eye.
    Type: Application
    Filed: December 23, 2009
    Publication date: April 22, 2010
    Applicant: ALCON, INC.
    Inventors: Bahram Asgharian, David L. Meadows
  • Publication number: 20090270345
    Abstract: The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
    Type: Application
    Filed: April 24, 2009
    Publication date: October 29, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Howard Allen KETELSON, James W. DAVIS, David L. MEADOWS
  • Patent number: 7552648
    Abstract: Methods of determining the mechanical properties of a sample include applying a first pressure condition to a first portion of the sample and applying a second pressure condition to the second portion of the sample, the second pressure condition being different than the first pressure condition.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: June 30, 2009
    Assignee: Halliburton Energy Services, Inc.
    Inventors: David E. McMechan, David L. Meadows
  • Publication number: 20090131303
    Abstract: The present invention is directed to ophthalmic compositions containing protease-inhibiting peptide substrates. In a preferred embodiment, the protease-inhibiting peptide substrate is gelatin. The compositions may also contain a galactomannan. In a particularly preferred embodiment, the compositions contain gelatin, a galactomannan and a borate salt. The present invention also describes methods of use of these compositions to inhibit protease MMP-9, and methods of topical administration of the compositions to the eye, particularly for the treatment of dry eye.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 21, 2009
    Inventors: BOR-SHYUE HONG, DAVID L. MEADOWS
  • Publication number: 20090084189
    Abstract: Methods of determining the mechanical properties of a sample include applying a first pressure condition to a first portion of the sample and applying a second pressure condition to the second portion of the sample, the second pressure condition being different than the first pressure condition.
    Type: Application
    Filed: September 28, 2007
    Publication date: April 2, 2009
    Inventors: David E. McMechan, David L. Meadows
  • Publication number: 20090030085
    Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.
    Type: Application
    Filed: October 3, 2008
    Publication date: January 29, 2009
    Applicant: ALCON, INC.
    Inventors: Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows