Abstract: Provided herein are compounds of formula (I?): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y2, Y3, L1, L2, X1, X2, X3, X4, X5, Q1, R1, R2, Rk, Rm, and Rn are as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (I?). Also provided herein are methods of inhibiting GYS1 and methods of treating a GYS1-mediated disease, disorder, or condition in an individual in need thereof.

Abstract: The present disclosure relates to lubricant compositions comprising a branched copolymer and methods for making such compositions. Lubricant compositions of the present disclosure comprise an oil and a copolymer and have a high temperature high shear (HTHS) viscosity of about 5 or less, shear stability index (30 cycles) of from about 2% to about 80%, a ratio of thickening efficiency to shear stability index (30 cycles) of from about 1:2 to about 1:30, a kinematic viscosity at 100° C. of from about 3 cSt to about 30 cSt, and a thickening efficiency of about 1 or more. In another class of embodiments, the present disclosure provides a lubricant composition comprising a first and a second copolymers wherein the first copolymer has an ethylene content higher than that of the second copolymer, and wherein at least one of the two copolymers is a long chain branched ethylene copolymer.

Abstract: Systems and methods for measuring analytes in fluid samples are disclosed. The systems and methods employ test strips which are generally comprised of a substrate, at least one electrical connection, at least one sensing chemistry and at least one additional layer. The test strips can be batch calibrated.

Abstract: The present disclosure also relates to lubrication compositions comprising a long branched ethylene copolymer and methods for making compositions. Compositions of the present disclosure can be a composition including an oil and a ethylene copolymer, the copolymer having one or more of an MWD from about 2.0 to about 6.5; an Mw(LS) from about 30,000 to about 300,000 g/mol; a g?vis of from about 0.5 to about 0.97; an ethylene content of about 40 wt % to less than 80 wt %. The compostion has a shear stability index (30 cycles) of from about 1% to about 60%; and a kinematic viscosity at 100° C. of from about 3 cSt to about 25 cSt. A method of making a composition includes blending an oil with a copolymer is also disclosed. Additionally, provided are novel long chain branched ethylene propylene copolymers and methods to produce such copolymers.

Abstract: Provided is a lubricating oil composition that includes a major amount of a lubricant base oil and a minor amount of a viscosity index improver comprising a syndiotactic propylene-based ethylene-propylene copolymer comprising: a) 2 to 20% by weight of ethylene, b) 80 to 98% by weight of propylene; c) 50 to 99% of rr triads; and d) Mw (LS) of 10 to 250 kg/mol.

Abstract: Provided is a lubricating oil composition that includes a major amount of a lubricant base oil and a minor amount of a viscosity index improver comprising a syndiotactic propylene-based ethylene-propylene copolymer comprising: a) 2 to 20% by weight of ethylene, b) 80 to 98% by weight of propylene; c) 50 to 99% of rr triads; and d) Mw (LS) of 10 to 250 kg/mol.

Abstract: Mouth guards of varying designs. The mouth guard is generally moldable and has non-planar biting surfaces. In other embodiments, the mouth guard has base members or flanges that have means for retaining medicaments and the like. Other versions have thermochromic elements selected to allow color changes at desired temperatures.

Abstract: Provided herein are telechelic polymers and methods for producing the same. In some embodiments, provided herein are compounds having the formula and methods for producing the same.

Abstract: Provided herein are methods for preparing a telechelic polymer of formula I wherein: R1 is a polyolefin group; R2 and R3 are, independently in each —(CR2R3)— unit, hydrogen or alkyl from 1 to 6 carbons; m is an integer from 2 to 20; RX is a cationic initiator residue; and p is an integer from 1 to 4.

Abstract: Provided herein are vinyl ether end-functionalized polyolefins and methods for producing the same.

Abstract: Sampling in the process of trans-raster distortion correction is described. The distortion parameterization is analyzed to determine the maximum inflation and deflation (magnification and minification) over the image. The maximum inflation is then used to determine the optimal resolution (dimensions in pixels) of the linear-projected image such that it is not undersampled by the output image. The maximum deflation, coupled with the optimal resolution determined in the inflation step, is then used to configure the filter used in the resampling process such that aliasing due to undersampling is minimized, while simultaneously controlling the computational burden of the filter.

Abstract: Mouth guards of varying designs. The mouth guard is generally moldable and has non-planar biting surfaces. In other embodiments, the mouth guard has base members or flanges that have means for retaining medicaments and the like. Other versions have thermochromic elements selected to allow color changes at desired temperatures.

Abstract: Provided herein are vinyl ether end-functionalized polyolefins and methods for producing the same.

Abstract: A user's physical location and the time the user is at that location are sampled by an network-enabled mobile computing device at certain intervals, and used to construct a representation of the comparative relevance of the different physical locations where the user lives. This representation is then used then to optimize and prioritize results returned by a local network search operation, informing the user about which search result would be optimal for the user at her intended time for use of that choice.

Abstract: Provided herein are vinyl ether end-functionalized polyolefins and methods for producing the same.

Abstract: Efficient determination of illumination over large 3D environments, including shadowing, is provided. Illumination, including shadows, is generated using a raster elevation map by a lighting solver. The lighting solver fetches the raster elevation map for an illumination area of interest at the paging rate and produces an illumination map that is applied to terrain and features by a 3D renderer. The lighting solver updates subsets of the illumination map as necessary to reflect changing illumination or movement of the visual area of interest.

Abstract: Provided herein are methods for preparing a telechelic polymer of formula I wherein R1 is a polyolefin group; R2 and R3 are, independently in each —(CR2R3)— unit, hydrogen or alkyl from 1 to 6 carbons; m is an integer from 2 to 20; RX is a cationic initiator residue; and p is an integer from 1 to 4.

Abstract: Mouth guards of varying designs. The mouth guard is generally moldable and has non-planar biting surfaces. In other embodiments, the mouth guard has base members or flanges that have means for retaining medicaments and the like. Other versions have thermochromic elements selected to allow color changes at desired temperatures.

Abstract: Provided herein are telechelic polymers and methods for producing the same. In some embodiments, provided herein are compounds having the formula and methods for producing the same.

Abstract: A wireless networked device incorporating a display, a video camera and a geo-location system receives geo-located data messages from a server system. Messages can be viewed by panning the device, revealing the message's real world location as icons and text overlaid on top of the camera input on the display. The user can reply to the message from her location, add data to an existing message at its original location, send new messages to other users of the system or place a message at a location for other users. World Wide Web geo-located data can be explored using the system's user interface as a browser. The server system uses the physical location of the receiving device to limit messages and data sent to each device according to range and filtering criteria, and can determine line of sight between the device and each actual message to simulate occlusion effects.