Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

Abstract: A nozzle for a low pressure fuel injection that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to the cylinder for an engine, at relatively low pressures. The nozzle includes a metering plate having inner and outer exit cavities in rings spaced circumferentially about a center exit cavity.

Abstract: A fuel injector having a nozzle with depressions for increasing fluid turbulence and preventing deposit build up within the injector to increase performance, longevity and fuel economy.

Abstract: A low pressure fuel injector capable of atomizing fuel at relatively low pressure is configured to have reduced hydraulic resistance. Reduction in the hydraulic resistance minimizes the pressure drop within the fuel injector and thereby improves atomization of the fuel for improved fuel economy and performance, and decreased emissions.

Abstract: A nozzle for a low pressure fuel injection that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to the cylinder for an engine.

Abstract: A nozzle for a low pressure fuel injection that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to the cylinder for an engine.

Abstract: Internal combustion engine (ICE) on-plug ignition coils with transistor drivers located in powertrain control modules (PCM) or other remote locations are prone to high electrical and magnetic interference (EMI) emissions and are subject to interference from other components due to long connecting wires. Ionization detection circuits have even greater sensitivity to EMI because of their very low signal current levels (mioroampere). The present feature of the invention integrates both the coil driver transistor and ionization detection circuits into the on-plug ignition coil. By placing the circuit on top or on the side of the coil, the connection distance from the circuit to the secondary winding is minimized. Thus, the circuit is less susceptible to electrical and electromagnetic noise.

Abstract: Internal combustion engine (ICE) on-plug ignition coils with transistor drivers located in powertrain control modules (PCM) or other remote locations are prone to high electrical and magnetic interference (EMI) emissions and are subject to interference from other components due to long connecting wires. Ionization detection circuits have even greater sensitivity to EMI because of their very low signal current levels (microampere). The present feature of the invention integrates both the coil driver transistor and ionization detection circuits into the on-plug ignition coil. In a preferred embodiment, parts rated at 140 degrees centigrade are used in both the coil driver transistor and the ionization circuits which are located on the coil to address temperature and thermal shock concerns. Additionally, parts rated at 20 G are used in both the coil driver transistor and the ionization circuits to address vibration concerns.

Abstract: A fuel injector assembly includes a valve to selectively prevent fuel from flowing therethrough. An armature is fixedly mounted onto the valve, and a solenoid is adapted to generate a magnetic flux within the fuel injector to provide a magnetic force on the armature. A flux washer is disposed between the solenoid and the armature and provides a path for the magnetic flux.

Abstract: The above objects and advantages are provided for in improved archery bow sight assembly which provides a floating two-pin sight system for sighting a target. According to the invention, a sight assembly body having a forward portion and rear portion is attached directly to the bow. Pivotally attached to the front portion is a floating sight pin. Pivotally attached to the rear portion is a floating peep sight. Movement of the sight pin and peep sight is caused by a sight adjustment lever. Gear teeth on the sight adjustment lever are meshingly engaged with gear teeth on the peep sight arm. The gear teeth of the adjustment lever are indirectly engaged with the sight pin arm via idler gears. This arrangement allows the peep sight and sight pin to move in the same direction as the sight adjustment lever is manipulated.

Abstract: A vehicle speed control system having phasing circuitry which provides a sequence of electrical phase steps in response to a comparison of actual vehicle speed to a desired vehicle speed. A stepper motor coupled to a pinion shaft rotates by discrete phase steps in response to the phasing circuitry. An anti-backlash/transfer gear assembly includes a first sprocket gear coupled to a second sprocket gear by integrally formed compression or flexure members which hold the sprocket gears together and a spring assembly which displaces the circumferential teeth of the two sprocket gears relative to one another. Another gear assembly couples rotational movement from the stepper motor to the engine throttle.

Abstract: A cable attachment assembly for coupling and uncoupling a cable to a throttle control system partially encased within a housing. The housing includes an opening aligned with a cable drum and a protrusion adjacent the opening. A cable cover assembly includes an integrally formed collar having a resilient member formed thereon with a first flap at its end. A second flap is integrally formed on the collar adjacent the first flap. During rotation in an assembly process, the resilient member is compressed as the first flap rotates along the protrusion. As the first flap passes the protrusion, the resilient member is outwardly deflected thereby locking the protrusion between the first and second flaps and, accordingly, locking the cable cover assembly to the housing.

Abstract: A switch includes three blade contact terminals against which is biased a rotating printed circuit board. The printed circuit board is rotationally moveable with respect to the blade contacts and has conductive elements on a first side of the printed circuit board for selectively contacting the switching contacts in response to the relative rotation between the switching contacts and the printed circuit board. The conductor elements include a tab for extending around the edge of the printed circuit board to a second side of the printed circuit board so as to provide electrically connected regions on both first and second sides of the printed circuit board. An electrically conducting resilient contact abuts the second side of the printed circuit board and biases the printed circuit board against the switching contacts. The tab and resilient contact can be coupled to a ground potential.

Abstract: A method to purify an aqueous solution of an alkali metal hydroxide by countercurrently contacting the ammonia and hydroxide, in a volume ratio of about 0.6 to 1 to about 1 to 1, in a packed bed. The temperature in the lower portion of an extractor in which the process is carried out is controlled and maintained within a range of at least about 155.degree. to about 170.degree. F.

Abstract: A fracture brace for a leg has an interior jacket for placement over the front of a leg, and for wrapping around the medial and lateral sides of a leg outside of a posterior shell. The posterior shell fits over the calf and the lateral and medial sides of the leg. Straps anchored on the shell unite the jacket and the shell to form an enveloping case for the leg that permits transmission of bearing pressures through the fleshy part of the leg, the tibia, and the brace. An interior pad integral with the jacket extends along the anterior of a leg from the proximal tibia to the distal tibia. There the pad wraps to the sides to provide padding for the bony prominences of the medial and lateral malleolus. A footplate connects to the jacket through a pair of uprights, each of which attaches to the footplate through a pivot and to the jacket by hook and pile fasteners.

Abstract: An orthopedic brace for treatment of idiopathic scoliosis or curvature of the spine. A brace with an anterior panel and spaced right and left posterior panels, with substantially rigid iliac crest members at each side joining the anterior panel to the respective posterior panels. Adjustable straps are provided for interconnecting the spaced posterior panels, and a flexible pelvic band is carried at the lower ends of the panels for positioning about the pelvis of the wearer. The various additional components may be added to the basic lumbar brace as desired, including a thoracic sling, an anterior sternal upright, a chest band, and a neck band.

Abstract: A reciprocating fuel pump for an internal combustion engine comprising a body having an outer wall defining a pumping chamber and a pair of generally cylindrical projections in fluid communication with the pumping chamber, the projections defining an intake cavity with an intake check valve therein and a discharge cavity with a discharge check valve therein. Elastomeric tubular conduits within the projections form the intake and discharge cavities and are of a flexibility sufficient to provide a collapsing and an expansion of the conduit walls upon relatively small pressure variations resulting from the suction and discharge strokes of the diaphragm. The elastomeric conduits thereby provide pulsating chambers to smooth out the flow of fuel and thereby increase the fuel flow through the fuel pump.