Patents by Inventor David L. Schlotterbeck
David L. Schlotterbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240034797Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.Type: ApplicationFiled: October 6, 2023Publication date: February 1, 2024Inventors: Thomas Emanuel ICHIM, Steven Francis JOSEPHS, Stephen Michael PRINCE, Amir JAFRI, Robert SEGAL, David L. SCHLOTTERBECK
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Patent number: 11814430Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.Type: GrantFiled: February 12, 2021Date of Patent: November 14, 2023Assignee: IMMUNICOM, INC.Inventors: Thomas Emanuel Ichim, Steven Francis Josephs, Stephen Michael Prince, Amir Jafri, Robert Segal, David L. Schlotterbeck
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Publication number: 20220041731Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.Type: ApplicationFiled: October 15, 2021Publication date: February 10, 2022Applicant: IMMUNICOM, INC.Inventors: Thomas Emanuel ICHIM, Steven Francis JOSEPHS, Stephen Michael PRINCE, Amir JAFRI, Robert SEGAL, David L. SCHLOTTERBECK
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Publication number: 20220041730Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment. removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.Type: ApplicationFiled: October 15, 2021Publication date: February 10, 2022Applicant: IMMUNICOM, INC.Inventors: Thomas Emanuel ICHIM, Steven Francis JOSEPHS, Stephen Michael PRINCE, Amir JAFRI, Robert SEGAL, David L. SCHLOTTERBECK
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Publication number: 20220041729Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.Type: ApplicationFiled: October 15, 2021Publication date: February 10, 2022Applicant: IMMUNICOM, INC.Inventors: Thomas Emanuel ICHIM, Steven Francis JOSEPHS, Stephen Michael PRINCE, Amir JAFRI, Robert SEGAL, David L. SCHLOTTERBECK
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Publication number: 20220041732Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.Type: ApplicationFiled: October 15, 2021Publication date: February 10, 2022Applicant: IMMUNICOM, INC.Inventors: Thomas Emanuel ICHIM, Steven Francis JOSEPHS, Stephen Michael PRINCE, Amir JAFRI, Robert SEGAL, David L. SCHLOTTERBECK
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Publication number: 20210198362Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.Type: ApplicationFiled: February 15, 2021Publication date: July 1, 2021Applicant: IMMUNICOM, INC.Inventors: Thomas Emanuel ICHIM, Steven Francis JOSEPHS, Stephen Michael PRINCE, Amir JAFRI, Robert SEGAL, David L. SCHLOTTERBECK
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Publication number: 20210163597Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.Type: ApplicationFiled: February 12, 2021Publication date: June 3, 2021Applicant: IMMUNICOM, INC.Inventors: Thomas Emanuel ICHIM, Steven Francis JOSEPHS, Stephen Michael PRINCE, Amir JAFRI, Robert SEGAL, David L. SCHLOTTERBECK
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Patent number: 10275571Abstract: A system and method for communicating and validating patient information including medication delivery information in a care-giving facility is provided. A medical transaction carrier is used to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. All information carried by the medical transaction carrier is validated both at the patient specific asset and at the control system. This validation allows for positive control of all transactions even if a medical transaction carrier is lost. The medical transaction carrier may be a smartcard, a FDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing and communicating information. The system may use either wired or wireless connections to communicate information between the components of the system.Type: GrantFiled: July 18, 2011Date of Patent: April 30, 2019Assignee: CareFusion 303, Inc.Inventors: Damon J. Coffman, Timothy W. Vanderveen, Bradford A. Lee, David L. Schlotterbeck
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Patent number: 9600633Abstract: A system and method for communicating and validating patient information including medication delivery information in a care-giving facility is provided. A medical transaction carrier is used to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. All information carried by the medical transaction carrier is validated both at the patient specific asset and at the control system. This validation allows for positive control of all transactions even if a medical transaction carrier is lost. The medical transaction carrier may be a smartcard, a PDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing and communicating information. The system may use either wired or wireless connections to communicate information between the components of the system.Type: GrantFiled: May 18, 2001Date of Patent: March 21, 2017Assignee: CareFusion 303, Inc.Inventors: Damon J. Coffman, Timothy W. Vanderveen, Bradford A. Lee, David L. Schlotterbeck
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Patent number: 9227025Abstract: An infusion data communication system provides a communication link among a fluid container, an infusion pump, and a patient through which identification data may be communicated. Data devices are located at the fluid container and the patient and conduct low frequency RF energy at a low power level containing the data into the medical fluid. The data-laden RF energy propagates through the medication fluid to data readers at the infusion pump which receives the RF energy and reads the data. A comparison is made to verify that the right medication is mounted to the infusion pump for administration to the right patient. RFID devices may be used for the data devices and readers. Pump programming data may also be propagated to the infusion pump from the container RFID tag. The RFID device at the patient may be writable and may be used to store a patient MAR.Type: GrantFiled: July 8, 2014Date of Patent: January 5, 2016Assignee: CareFusion 303, Inc.Inventors: Robert D. Butterfield, David L. Schlotterbeck
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Publication number: 20140324019Abstract: An infusion data communication system provides a communication link among a fluid container, an infusion pump, and a patient through which identification data may be communicated. Data devices are located at the fluid container and the patient and conduct low frequency RF energy at a low power level containing the data into the medical fluid. The data-laden RF energy propagates through the medication fluid to data readers at the infusion pump which receives the RF energy and reads the data. A comparison is made to verify that the right medication is mounted to the infusion pump for administration to the right patient. RFID devices may be used for the data devices and readers. Pump programming data may also be propagated to the infusion pump from the container RFID tag. The RFID device at the patient may be writable and may be used to store a patient MAR.Type: ApplicationFiled: July 8, 2014Publication date: October 30, 2014Inventors: Robert D. Butterfield, David L. Schlotterbeck
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Patent number: 8777894Abstract: An infusion data communication system provides a communication link among a fluid container, an infusion pump, and a patient through which identification data may be communicated. Data devices are located at the fluid container and the patient and conduct low frequency RF energy at a low power level containing the data into the medical fluid. The data-laden RF energy propagates through the medication fluid to data readers at the infusion pump which receives the RF energy and reads the data. A comparison is made to verify that the right medication is mounted to the infusion pump for administration to the right patient. RFID devices may be used for the data devices and readers. Pump programming data may also be propagated to the infusion pump from the container RFID tag. The RFID device at the patient may be writable and may be used to store a patient MAR.Type: GrantFiled: November 7, 2011Date of Patent: July 15, 2014Assignee: CareFusion 303, Inc.Inventors: Robert D. Butterfield, David L. Schlotterbeck
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Patent number: 8645154Abstract: The present invention is directed to a system and method for providing care to a patient, comprising a patient care device having a number of configuration databases stored in a memory in the device. Each configuration database preferably includes protocols, operating limits, rule sets and/or operating features that collectively define an operating environment, or personality, of the device. Selection of a specific configuration database preferably is based at least in part upon patient-specific information obtained from any location in a distributed hospital network. Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. In a preferred embodiment, programming a patient care device to deliver a drug to a patient entails activating a configuration database and scanning a machine-readable drug label identifying a particular protocol stored in the activated database.Type: GrantFiled: December 23, 2005Date of Patent: February 4, 2014Assignee: CareFusion 303, Inc.Inventors: Philip N. Eggers, David L. Schlotterbeck, Timothy W. Vanderveen, Damon J. Coffman
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Patent number: 8639521Abstract: The present invention is directed to a system and method for providing care to a patient, comprising a patient care device having a number of configuration databases stored in a memory in the device. Each configuration database preferably includes protocols, operating limits, rule sets and/or operating features that collectively define an operating environment, or personality, of the device. Selection of a specific configuration database preferably is based at least in part upon patient-specific information obtained from any location in a distributed hospital network. Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. In a preferred embodiment, programming a patient care device to deliver a drug to a patient entails activating a configuration database and scanning a machine-readable drug label identifying a particular protocol stored in the activated database.Type: GrantFiled: December 23, 2005Date of Patent: January 28, 2014Assignee: CareFusion 303, Inc.Inventors: Philip N. Eggers, David L. Schlotterbeck, Timothy W. Vanderveen, Damon J. Coffman
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Publication number: 20120053533Abstract: An infusion data communication system provides a communication link among a fluid container, an infusion pump, and a patient through which identification data may be communicated. Data devices are located at the fluid container and the patient and conduct low frequency RF energy at a low power level containing the data into the medical fluid. The data-laden RF energy propagates through the medication fluid to data readers at the infusion pump which receives the RF energy and reads the data. A comparison is made to verify that the right medication is mounted to the infusion pump for administration to the right patient. RFID devices may be used for the data devices and readers. Pump programming data may also be propagated to the infusion pump from the container RFID tag. The RFID device at the patient may be writable and may be used to store a patient MAR.Type: ApplicationFiled: November 7, 2011Publication date: March 1, 2012Applicant: CareFusion 303, Inc.Inventors: Robert D. Butterfield, David L. Schlotterbeck
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Patent number: 8075514Abstract: An infusion data communication system provides a communication link among a fluid container, an infusion pump, and a patient through which identification data may be communicated. Data devices are located at the fluid container and the patient and conduct low frequency RF energy at a low power level containing the data into the medical fluid. The data-laden RF energy propagates through the medication fluid to data readers at the infusion pump which receives the RF energy and reads the data. A comparison is made to verify that the right medication is mounted to the infusion pump for administration to the right patient. RFID devices may be used for the data devices and readers. Pump programming data may also be propagated to the infusion pump from the container RFID tag. The RFID device at the patient may be writable and may be used to store a patient MAR.Type: GrantFiled: March 29, 2004Date of Patent: December 13, 2011Assignee: CareFusion 303, Inc.Inventors: Robert D. Butterfield, David L. Schlotterbeck
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Publication number: 20110282691Abstract: A system and method for communicating and validating patient information including medication delivery information in a care-giving facility is provided. A medical transaction carrier is used to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. All information carried by the medical transaction carrier is validated both at the patient specific asset and at the control system. This validation allows for positive control of all transactions even if a medical transaction carrier is lost. The medical transaction carrier may be a smartcard, a FDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing and communicating information. The system may use either wired or wireless connections to communicate information between the components of the system.Type: ApplicationFiled: July 18, 2011Publication date: November 17, 2011Applicant: CareFusion 303, Inc.Inventors: Damon J. Coffman, Timothy W. Vanderveen, Bradford A. Lee, David L. Schlotterbeck
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Patent number: 8005688Abstract: A system and method for communicating and validating patient information including medication delivery information in a care-giving facility is provided. A medical transaction carrier is used to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. All information carried by the medical transaction carrier is validated both at the patient specific asset and at the control system. This validation allows for positive control of all transactions even if a medical transaction carrier is lost. The medical transaction carrier may be a smartcard, a PDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing and communicating information. The system may use either wired or wireless connections to communicate information between the components of the system.Type: GrantFiled: November 7, 2005Date of Patent: August 23, 2011Assignee: CareFusion 303, Inc.Inventors: Damon J. Coffman, Bradford A. Lee, Timothy W. Vanderveen, David L. Schlotterbeck
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Publication number: 20110060758Abstract: A system and method for confirming that a medication administration device has been programmed with the correct medication administration parameters. A medical database carrier is used compare medication delivery parameters entered into a medication administration device to institutionally established guidelines or more widely accepted protocols to ensure that the medication is delivered in accordance to those guidelines. The medical database carrier may also be configured to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. The medical database carrier may be a smartcard, a PDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing, processing and communicating information.Type: ApplicationFiled: November 16, 2010Publication date: March 10, 2011Applicant: CareFusion 303, Inc.Inventors: DAVID L. SCHLOTTERBECK, Stuart E. Rickerson, Damon J. Coffman, Timothy W. Vanderveen, Bradford A. Lee