Patents by Inventor David L. Silver

David L. Silver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF HEPATIC INSULIN RESISTANCE
    Publication number: 20120269720
    Abstract: Disclosed are methods for determining whether a subject may have hepatic insulin resistance, for diagnosing hepatic insulin resistance, and for assessing the prognosis of a subject with hepatic insulin resistance, comprising determining the level of expression of major facilitator superfamily domain 2 protein (Mfsd2) in a subject's liver, where overexpression of Mfsd2 is indicative of hepatic insulin resistance.
    Type: Application
    Filed: June 16, 2010
    Publication date: October 25, 2012
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: David L. Silver
  • Regulation of lipid droplet formation by modulation of FIT1 and FIT2 and uses thereof
    Patent number: 8129121
    Abstract: This invention provides methods of regulating fat storage in tissue by modulating the levels of Fibrate Induced Transcript 1 (FIT1) and/or Fibrate Induced Transcript 2 (FIT2), as well as diagnostic screens for disorders and conditions involving regulation of fat storage in tissue, assays for identifying agents that can regulate fat storage in tissue through modulating the levels of FIT1 and/or FIT2, and genetically altered mammals in which expression of FIT1 and/or FIT2 is altered in one or more tissue.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: March 6, 2012
    Assignees: Albert Einstein College of Medicine of Yeshiva University, The Trustees of Columbia University in the City of New York
    Inventor: David L. Silver
  • REGULATION OF LIPID DROPLET FORMATION BY MODULATION OF FIT1 AND FIT2 AND USES THEREOF
    Publication number: 20100095391
    Abstract: This invention provides methods of regulating fat storage in tissue by modulating the levels of Fibrate Induced Transcript 1 (FIT1) and/or Fibrate Induced Transcript 2 (FIT2), as well as diagnostic screens for disorders and conditions involving regulation of fat storage in tissue, assays for identifying agents that can regulate fat storage in tissue through modulating the levels of FIT1 and/or FIT2, and genetically altered mammals in which expression of FIT1 and/or FIT2 is altered in one or more tissue.
    Type: Application
    Filed: January 8, 2008
    Publication date: April 15, 2010
    Inventor: David L. Silver
  • ABCA1 PEST domain-related compositions and methods
    Publication number: 20040096851
    Abstract: This invention provides an isolated ABCA1 protein having a mutation within its PEST domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a protease inhibitor increases the rate of cholesterol efflux from a cell, for increasing ABCA1-mediated cholesterol efflux from a cell, for treating atherosclerosis in a subject, and for increasing HDL formation in a subject.
    Type: Application
    Filed: April 28, 2003
    Publication date: May 20, 2004
    Inventors: Nan Wang, Alan R. Tall, David L. Silver