Patents by Inventor David L. Spector

David L. Spector has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING BREAST CANCER
    Publication number: 20220143066
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a MaTAR in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate breast cancer in an individual in need.
    Type: Application
    Filed: June 15, 2021
    Publication date: May 12, 2022
    Inventors: David L. Spector, Sarah Daniela Diermeier, Frank Rigo, C. Frank Bennett, Susan M. Freier, Gayatri Arun, Kung-Chi Chang
  • MODULATION OF LNC05 EXPRESSION
    Publication number: 20210290653
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of lnc05 in a cell or individual. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a cancer in an individual.
    Type: Application
    Filed: June 3, 2021
    Publication date: September 23, 2021
    Inventors: Allen Tingjin Yu, David L. Spector, Frank Rigo, Susan M. Freier, Jan Bergmann, Carmen Berasain
  • Methods of treating breast cancer
    Patent number: 11058709
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a MaTAR in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate breast cancer in an individual in need.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: July 13, 2021
    Assignees: Ionis Pharmaceuticals, Inc., Cold Spring Harbor Laboratory
    Inventors: David L. Spector, Sarah Daniela Diermeier, Frank Rigo, C. Frank Bennett, Susan M. Freier, Gayatri Arun, Kung-Chi Chang
  • Modulation of Lnc05 expression
    Patent number: 11033570
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of Inc05 in a cell or individual. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a cancer in an individual.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 15, 2021
    Assignees: Cold Spring Harbor Laboratory, Ionis Pharmaceuticals, Inc.
    Inventors: Allen Tingjin Yu, David L. Spector, Frank Rigo, Susan M. Freier, Jan Bergmann, Carmen Berasain
  • MODULATION OF LNC05 EXPRESSION
    Publication number: 20190343863
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of Inc05 in a cell or individual. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a cancer in an individual.
    Type: Application
    Filed: December 1, 2017
    Publication date: November 14, 2019
    Applicants: Cold Spring Harbor Laboratory, Ionis Pharmaceuticals, Inc.
    Inventors: Allen Tingjin Yu, David L. Spector, Frank Rigo, Susan M. Freier, Jan Bermann, Carmen Berasain
  • Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
    Patent number: 9845467
    Abstract: The present invention provides compounds and methods for modulating target nucleic acids found in organelles or sub-organelles of cells. The invention includes, but is not limited to compounds and methods that modulate target nucleic acids in a sub-nuclear organelle, such as the nucleolus and/or a cajal body. In certain embodiments, the cell is in an animal.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: December 19, 2017
    Assignees: Ionis Pharmaceuticals, Inc., Cold Spring Harbor Laboratory
    Inventors: Xue-hai Liang, Stanley T. Crooke, C. Frank Bennett, David L. Spector
  • COMPOUNDS AND METHODS FOR MODULATING TARGET NUCLEAR AND SUB-NUCLEAR NUCLEIC ACID MOLECULES IN CELLS AND ANIMALS
    Publication number: 20160194637
    Abstract: The present invention provides compounds and methods for modulating target nucleic acids found in organelles or sub-organelles of cells. The invention includes, but is not limited to compounds and methods that modulate target nucleic acids in a sub-nuclear organelle, such as the nucleolus and/or a cajal body. In certain embodiments, the cell is in an animal.
    Type: Application
    Filed: March 4, 2016
    Publication date: July 7, 2016
    Applicants: Ionis Pharmaceuticals, Inc., Cold Spring Harbor Laboratory
    Inventors: Xue-hai Liang, Stanley T. Crooke, C. Frank Bennett, David L. Spector
  • PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER
    Publication number: 20160109456
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
    Type: Application
    Filed: October 15, 2015
    Publication date: April 21, 2016
    Inventors: Sui Huang, Rajesh V. Kamath, David L. Spector, Ann D. Thor, Chen Wang
  • PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER
    Publication number: 20120309017
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
    Type: Application
    Filed: August 14, 2012
    Publication date: December 6, 2012
    Applicants: COLD SPRING HARBOR LABORATORY, NORTHWESTERN UNIVERSITY
    Inventors: Sui Huang, Rajesh V. Kamath, David L. Spector, Ann D. Thor, Chen Wang
  • Perinucleolar compartment as a cancer marker
    Patent number: 8241862
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: August 14, 2012
    Assignees: Northwestern University, Cold Spring Harbor Laboratory
    Inventors: Sui Huang, Rajesh V. Kamath, David L. Spector, Ann D. Thor, Chen Wang
  • PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER
    Publication number: 20100075365
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
    Type: Application
    Filed: September 15, 2009
    Publication date: March 25, 2010
    Applicants: NORTHWESTERN UNIVERSITY, COLD SPRING HARBOR LABORATORY
    Inventors: Sui Huang, Rajesh V. Kamath, David L. Spector, Ann D. Thor, Chen Wang