Patents by Inventor David L. Steed
David L. Steed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8647662Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.Type: GrantFiled: November 13, 2012Date of Patent: February 11, 2014Assignee: Stemnion, Inc.Inventors: David L. Steed, Linda O. Palladino
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Patent number: 8647663Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.Type: GrantFiled: November 14, 2012Date of Patent: February 11, 2014Assignee: Stemnion, Inc.Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
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Patent number: 8642027Abstract: The invention is directed to methods of modulating ischemic injury in tissues and organs. The invention is further directed to methods of increasing time to ischemic injury in tissues and organs. Such methods utilize compositions comprising cells capable of modulating inflammatory responses, referred to herein as Inflammatory Response Modulating Cells (IRMCs). The IRMCs any be used directly or cell membranes derived from them may be used in practicing the methods of the invention. In addition, the IRMCs and IRMC membranes may be used alone or in combination with each other and/or in combination with various suitable active agents.Type: GrantFiled: August 25, 2011Date of Patent: February 4, 2014Assignee: Stemnion, Inc.Inventors: Richard A. Banas, David L. Steed, Randall G. Rupp
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Patent number: 8642547Abstract: The invention is directed to methods for accelerating the healing of connective tissue injuries and disorders. In particular, the invention is directed to accelerating the healing of injuries and disorders of tendons and ligaments. Such methods utilize novel compositions including, but not limited to, extraembryonic cytokine-secreting cells (herein referred to as ECS cells), including, but not limited to, Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as Amnion-derived Cellular Cytokine Solution or ACCS), including pooled ACCS, and Physiologic Cytokine Solution (PCS).Type: GrantFiled: January 7, 2012Date of Patent: February 4, 2014Assignee: Stemnion, Inc.Inventors: George L. Sing, David L. Steed
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Patent number: 8630810Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.Type: GrantFiled: March 19, 2012Date of Patent: January 14, 2014Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Gilles Clermont, Patricia A. Hebda, Yee Key Li, Qi Mi, David L. Steed, Joshua Thomas Sullivan, Katherine Verdolini Abbott, Yoram Vodovotz, Ivan Petrov Yotov, Gary An
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Patent number: 8454957Abstract: The invention is directed to methods for treating coagulation disorders, in particular, hemophilia. Such methods utilize novel compositions including Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) alone or in combination with other agents and/or treatment modalities.Type: GrantFiled: June 17, 2011Date of Patent: June 4, 2013Assignee: Stemnion, Inc.Inventors: David L. Steed, William J. Golden
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Patent number: 8318197Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.Type: GrantFiled: January 17, 2012Date of Patent: November 27, 2012Assignee: Stemnion, Inc.Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
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Patent number: 8313764Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.Type: GrantFiled: June 20, 2011Date of Patent: November 20, 2012Assignee: Stemnion, Inc.Inventors: David L. Steed, Linda O. Palladino
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Publication number: 20120271611Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.Type: ApplicationFiled: March 19, 2012Publication date: October 25, 2012Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Gilles Clermont, Patricia A. Hebda, Yee Key Li, Qi Mi, David L. Steed, Joshua Thomas Sullivan, Katherine Verdolini Abbott, Yoram Vodovotz, Ivan Petrov Yotov, Gary An
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Publication number: 20120184975Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.Type: ApplicationFiled: January 17, 2012Publication date: July 19, 2012Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
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Publication number: 20120177633Abstract: The invention is directed to methods for accelerating the healing of connective tissue injuries and disorders. In particular, the invention is directed to accelerating the healing of injuries and disorders of tendons and ligaments. Such methods utilize novel compositions including, but not limited to, extraembryonic cytokine-secreting cells (herein referred to as ECS cells), including, but not limited to, Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as Amnion-derived Cellular Cytokine Solution or ACCS), including pooled ACCS, and Physiologic Cytokine Solution (PCS).Type: ApplicationFiled: January 7, 2012Publication date: July 12, 2012Inventors: George L. Sing, David L. Steed
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Patent number: 8165819Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.Type: GrantFiled: October 10, 2007Date of Patent: April 24, 2012Assignee: The University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Gilles Clermont, Patricia A. Hebda, Yee Key Li, Qi Mi, David L. Steed, Joshua Thomas Sullivan, Katherine Verdolini Abbott, Yoram Vodovotz, Ivan Petrov Yotov, Gary An
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Publication number: 20120052045Abstract: The invention is directed to methods of modulating ischemic injury in tissues and organs. The invention is further directed to methods of increasing time to ischemic injury in tissues and organs. Such methods utilize compositions comprising cells capable of modulating inflammatory responses, referred to herein as Inflammatory Response Modulating Cells (IRMCs). The IRMCs any be used directly or cell membranes derived from them may be used in practicing the methods of the invention. In addition, the IRMCs and IRMC membranes may be used alone or in combination with each other and/or in combination with various suitable active agents.Type: ApplicationFiled: August 25, 2011Publication date: March 1, 2012Inventors: Richard A. Banas, David L. Steed, Randall G. Rupp
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Publication number: 20110311609Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.Type: ApplicationFiled: June 20, 2011Publication date: December 22, 2011Inventors: David L. Steed, Linda O. Palladino
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Publication number: 20110311513Abstract: The invention is directed to methods for treating coagulation disorders, in particular, hemophilia. Such methods utilize novel compositions including Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) alone or in combination with other agents and/or treatment modalities.Type: ApplicationFiled: June 17, 2011Publication date: December 22, 2011Inventors: David L. Steed, William J. Golden
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Patent number: 7438164Abstract: A shock absorber includes a pressure tube with a piston slidably disposed therein. A separate valve includes a fluid circuit for fluid low in rebound and a fluid circuit for fluid flow in compression. Each fluid circuit includes a variable orifice which allows selection between a firm rebound with a soft compression, a soft rebound with a soft compression and a soft rebound with a firm compression. Each variable orifice is in communication with a blowoff valve in such a manner that they provide a variable blowoff feature to the blowoff valves.Type: GrantFiled: December 8, 2003Date of Patent: October 21, 2008Assignee: Tenneco Automotive Operating Company Inc.Inventors: Gary W Groves, Karl Kazmirski, David L Steed, Michael L Zebolsky
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Publication number: 20080228456Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.Type: ApplicationFiled: October 10, 2007Publication date: September 18, 2008Inventors: Gilles Clermont, Patricia A. Hebda, Yee Key Li, Qi Mi, David L. Steed, Joshua Thomas Sullivan, Katherine Verdolini Abbott, Yoram Vodovotz, Ivan Petrov Yotov, Gary An
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Patent number: 6793048Abstract: A shock absorber includes a pressure tube with a piston slidably disposed therein. A separate valve includes a fluid circuit for fluid low in rebound and a fluid circuit for fluid flow in compression. Each fluid circuit includes a variable orifice which allows selection between a firm rebound with a soft compression, a soft rebound with a soft compression, and a soft rebound with a firm compression. Each variable orifice is in communication with a blowoff valve in such a manner that they provide a variable blowoff feature to the blowoff valves.Type: GrantFiled: July 24, 2000Date of Patent: September 21, 2004Assignee: Tenneco Automotive Operating Company Inc.Inventors: Gary W. Groves, Karl Kazmirski, David L. Steed, Michael L. Zebolsky
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Patent number: 6464048Abstract: A shock absorber includes a pressure tube with a piston slidably disposed therein. A separate valve includes a fluid circuit for fluid low in rebound and a fluid circuit for fluid flow in compression. Each fluid circuit includes a variable orifice which allows selection between a firm rebound with a soft compression, a soft rebound with a soft compression and a soft rebound with a firm compression. Each variable orifice is in communication with a blowoff valve in such a manner that they provide a variable blowoff feature to the blowoff valves.Type: GrantFiled: July 24, 2000Date of Patent: October 15, 2002Assignee: Tenneco Automotive Inc.Inventors: Gary W. Groves, Karl Kazmirski, David L. Steed, Michael L. Zebolsky
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Patent number: 6460664Abstract: A shock absorber includes a valve assembly with a low speed valving system and a high speed valving system. Both systems control fluid flow through the respective valve assembly for fluid flow in the same direction. The low speed valving system is independently tunable in order to provide low speed damping to improve both the vehicle control and handling. The independent tuning of the low speed valving system allows the optimization of the low speed valving system in relation to the high speed valving system as well as the independent tuning of the high speed valving system in relation to the low speed valving system. The independent tuning of the two systems allow the achievement of a smooth transition between the two systems. The dual valving systems can be incorporated into the piston for a compression stroke, be incorporated into the piston for an extension stroke, or two dual valving systems can be incorporated into the piston for compression and extension strokes.Type: GrantFiled: May 22, 2000Date of Patent: October 8, 2002Assignee: Tenneco Automotive Inc.Inventors: David L. Steed, Michael L. Zebolsky, Dean R. Dodge