Abstract: Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, z and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Described herein are methods for treating ALK5-mediated disease including myelodysplastic syndrome (MDS), anemia and anemia of chronic disease. Also provided are methods of inhibiting ALK5.

Abstract: Systems and methods for implementing a representative support system in a task determination system are provided. The task determination system automatically receives in real-time a set of messages between a member and a representative as these messages are exchanged. The set of messages correspond to a set of proposals associated with a task. The task determination system automatically identifying a selection of a proposal from the set of proposals based on an analysis of the set of messages. Based on the selection, the task determination system generates a set of proposal tasks and processes communications associated with these proposal tasks to monitor performance of these proposal tasks for completion of the task.

Abstract: Systems and methods for communicating proposals in a task determination system are provided. The task determination system can generate in real-time a set of proposals corresponding to a task. The set of proposals are generated based on a task type and a member profile associated with a member for whom the task is being performed. The task determination system generates a ranking of the set of proposals based on suitability metrics between the task and the set of proposals. Based on the ranking and these suitability metrics, one or more proposals are selected for presentation to the member. The member profile associated with the member can be updated in real-time as the member interacts with the one or more proposals.

Abstract: Systems and methods for proposal acceptance in a task determination system are provided. The task determination system receives in real-time a set of messages through a communications session associated with a task. The set of messages are processed in real-time to identify a response to a set of proposals for completion of the task. Based on the response, the task determination system generates one or more proposal tasks performable to complete the task. The task determination system performs one or more actions according to the one or more proposal tasks to complete the task. The task determination system updates the member profile in real-time based on these actions, the task, and the response to the set of proposals.

Abstract: Systems and methods for proposal generation in a task recommendation system are provided. A task recommendation system may receive a completed task template corresponding to a task associated with a member. The task recommendation system may automatically query a resource library in real-time to identify a proposal template corresponding to the task type. The task recommendation system may then identify a proposal recommendation for a proposal option associated with a set of proposal options included in the proposal template. The task recommendation system may generate and present a proposal that includes the proposal recommendation. Based on member interaction with the proposal, the task recommendation system may update the member profile and the resource library.

Abstract: Disclosed embodiments provide a framework to identify and recommend tasks that can be performed for the benefit of a member. Through this framework, a member is assigned with a representative that, over time, learns about the member's preferences and behavior, which can be used to recommend tasks that can be performed to reduce the member's cognitive load. Further, as the representative develops a relationship with the member over time, the representative can also curate experiences for the member and assist the member in achieving personal goals and ambitions.