Abstract: The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono- and di-amino acids, their esters and amides, and catecholamine-like derivatives, of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.

Abstract: The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono- and di-amino acids, their esters and amides, and catecholamine-like derivatives, of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.

Abstract: A method is provided utilizing contrast agents which provide increased diagnostic information in the magnetic resonance image of the hepatobiliary system and alimentary tract, especially the small intestine. Novel contrast agents which are N-carboxylated desferrioxamine B complexes with metal ions are provided.

Abstract: Focusing apparatus is described for a lens holder for an actuator of a read/write head in a optical information storage system which provides a fine adjustment for focussing an optical beam on the storage medium. A lens holder unit is coupled to a base unit by springs, the springs establishing an equilibrium position relative to a base unit. The base unit includes a plurality of coils through which current can flow. The lens holder unit includes a permanent magnet. When current flows through the plurality of coils, a force is exerted on the permanent magnet and, consequently, on the lens holder unit. The position of the lens holder unit relative to the base unit is determined by the magnitude of the current applied to the coils. The springs are arranged to maintain an orientation of the lens assembly unit in space. For small displacements of the lens assembly unit from an equilibrium position, the lens remains proximate the optic axis.

Abstract: A camping light holder for maintaining a camping light a distance from a support structure is provided. The camping light holder includes a pole assembly, and a clamping assembly. The pole assembly includes a plurality of interconnecting sections. The pole assembly is inserted into a sleeve which is secured to the clamping assembly. The clamping assembly is removably secured to the support structure and includes a spike secured thereon for insertion into a penetrable support structure. A base may also be secured to the clamping assemble such that the camping light holder may be secured to support structures having a non-penetrable surface or a surface consisting of loose soil.

Abstract: Methods are provided for in vivo magnetic resonance imaging and/or scintigraphic imaging of a subject using chelated transition metal and lanthanide metal complexes. Novel ligands for these complexes are provided.

Abstract: A method is provided utilizing contrast agents which provide increased diagnostic information in the magnetic resonance image of the hepatobiliary system and alimentary tract, especially the small intestine. Novel contrast agents which are N-carboxylated desferrioxamine B complexes with metal ions are provided.

Abstract: New radiopharmaceutical compositions for use in nuclear medicine comprise radioastatinated benzylguanidine and radioastatinated carboxamidino phenylpiperazine. These compositions are used for treatment of disease, including neuroendocrine tumors, and specifically neuroblastoma.

Abstract: New radiopharmaceutical compositions for use in nuclear medicine comprise radioastatinated benzylguanidine and radioastatinated carboxamidino phenylpiperazine. These compositions are used for treatment of disease, including neuroendocrine tumors, and specifically neuroblastoma.

Abstract: Apparatus for controlling the radial position of a transducer (e.g. an optical, magneto-optic, or magnetic write/read head) relative to a spinning disk (e.g. a data storage disk) comprises a transducer-supporting radial access arm which is mounted via a rotary bearing for pivotal movement about a spinning support shaft. The continuous rotary movement of the support shaft dramatically reduces stick-slip friction in the bearings separating the support shaft and the access arm, thereby reducing start-up torque and enabling more precise positioning of the transducer relative to the disk. Moreover, it prolongs the life of the rotary bearing in that it eliminates so-called Brinelling (wearing of the bearing balls or rollers due to small oscillations about the same point).

Abstract: An electric motor is disclosed which is of the brushless DC type and comprises a generally planar rotor and a generally planar stator. The rotor is a multipolar permanent magnet and is adapted is rotate with a driven element. The stator includes a motor coil and a control section having control elements for regulating current in the coil. In order to provide a motor which has an improved arrangement for connecting the coil to the control elements and is relatively inexpensive to manufacture, the motor coil is formed integrally with the control section, and the control elements are connected to a conductor pattern in the control section.

Abstract: A shutter is disclosed for use as a high-speed shutter in a camera or an electronic device. The shutter comprises a planar aperture blade which is mounted for reciprocative movement. The aperture blade includes a coil which is part of an electromagnetic actuator. A permanent magnet is mounted adjacent the blade for interaction with a magnetic field produced by the coil. In order to provide for a low-friction support, the aperture blade is supported on flexible connectors located on opposite sides of the blade. A current of one polarity is supplied to the coil to move the aperture blade in one direction, and the polarity of the current is reversed to move the blade in the opposite direction.

Abstract: Chelating agents having 1-hydroxy-2-pyridinone (HOPO) and related moieties incorporated within their structures, including polydentate HOPO-substituted polyamines such as spermidine and spermine, and HOPO-substituted desferrioxamine. The chelating agents are useful in selectively removing certain cations from solution, and are particularly useful as ferric ion and actinide chelators. Novel syntheses of the chelating agents are provided.

Abstract: In an electromagnetic actuator of the type having a planar coil armature mounted for movement in a magnetic field by a plurality of planar flexure springs, the flexure springs lie entirely in the plane of the planar armature.

Abstract: An electromagnetic actuator operable with a source of electric current has two overlapping, oppositely movable armatures that are mounted on resiliently flexible cantilever spring members and coupled together by resiliently flexible spring elements, to provide coordinated cooperative movements of the armatures when energized. The armatures have conductive coils thereon that are connectable to the current source through the spring members and spring elements. A permanent magnet and a pair of flux return plates are disposed near the armatures to provide a suitable magnetic path through the coils. Current flowing through the coils in the magnetic path generates oppositely directed forces on the two armatures. Structure is provided for constraining the coupling spring elements to move in only one direction when such forces are generated, thereby facilitating coordination of desired armature movements in directions substantially opposite to each other and perpendicular to the one direction.

Abstract: A body implantable lead having an anchoring sleeve slideably affixed thereto. The anchoring sleeve is generally cylindrical in shape, having a cylindrical lumen through which the main body of the body implantable lead passes. Since the lumen within the anchoring sleeve is smaller than the diameter of the electrode fixation device at the distal end and the electrical connector at the proximal end of the body implantable lead, the anchoring sleeve is fixedly, though slideably attached to the body implantable lead. The anchoring sleeve is molded of a body compatible material such as silicone or polyurethane. Small serrations of body compatible material within the lumen of the anchoring sleeve generate sufficient friction such that the anchoring sleeve does not slide along the body implantable lead from the sheer force of gravity. The distal end of the anchoring sleeve is tapered or otherwise suitably shaped to permit it to occlude a permanent lead introducer and/or blood vessel during implantation.

Abstract: A collapsible meal box having an axle inserted through a pair of openings in the sidewalls of the meal box to prevent the base of the meal box from being moved between the sidewalls into the meal box interior, and thereby prevent the meal box from being collapsed. A pair of wheels are mounted on the axle ends to form an amusement device for children.

Abstract: Technique for permitting ease of mapping of the myocardial tissues during implantation of a myocardial electrode. The technique employs the use of a disposable exploring needle located on the distal end of the implantable lead assembly. The permanent electrode is attached to the exploring needle by being embedded into an electrically conducting material of the exploring needle. The implanting physician explores the electrical characteristics of the myocardial tissues using the exploring needle. Upon finding the desired electrode location, the exploring needle is removed and discarded and the electrode is permanently attached in the manner customary in the prior art.

Abstract: An amusement device, such as a doll, comprising a body formed of a relatively rigid paperboard having a plurality of circular openings, and a controlled member on the front of the body adjacent each of the openings, a handle on the rear of the body, each controlled member having a pair of spaced tabs extending through its corresponding body opening and a corresponding opening in the handle, the ends of the tabs being tapered in such a manner that as the handle is moved in a closed curved motion, each controlled member is moved in an independent, predetermined path of motion. The controlled members can take the shape of eyes or other objects on the front of the doll.

Abstract: A transvenous pacing lead suitable for chronic implantation having structure which permits dispensing of drugs or other chemical agents from the ring tip electrode upon physician discretion from implant through chronic implantation. A bipolar, tined endocardial ventricular lead has a plurality of small apertures within the ring tip electrode which are connected by a tube within the lead body to a bladder at the proximal end of the lead. The bladder is detachable to permit a stylet to be passed through the tube to guide the lead during implantation. A reed valve at the distal end of the tube prevents body fluid from entering the tube. A stylet restraint prevents the stylet from damaging the reed valve during implant.