Patents by Inventor David L. Yang

David L. Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230021705
    Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.
    Type: Application
    Filed: April 19, 2022
    Publication date: January 26, 2023
    Inventors: Megan K. Armstrong, Gediminas J. Brizgys, James S. Cassidy, Elbert Chin, Chienhung Chou, Chao-I Hung, David W. Lin, Michael L. Mitchell, Ezra Roberts, Scott D. Schroeder, James G. Taylor, Rhiannon Thomas-Tran, Nathan E. Wright, Zheng-Yu Yang
  • Publication number: 20220331346
    Abstract: Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: May 4, 2021
    Publication date: October 20, 2022
    Inventors: Alaric J. DYCKMAN, T.G. Murali Dhar, Hai-Yun Xiao, John L. Gilmore, Michael G. Yang, Zili Xiao, David Marcoux
  • Publication number: 20220220078
    Abstract: Provided is a compound of formula (I) in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
    Type: Application
    Filed: January 10, 2022
    Publication date: July 14, 2022
    Inventors: David J. MALONEY, Alex Gregory WATERSON, Ganesh Rai BANTUKALLU, Kyle Ryan BRIMACOMBE, Plamen CHRISTOV, Chi V. DANG, Victor DARLEY-USMAR, Xin HU, Ajit JADHAV, Somnath JANA, Kwangho KIM, Jennifer L. KOUZNETSOVA, William J. MOORE, Bryan T. MOTT, Leonard M. NECKERS, Anton SIMEONOV, Gary Allen SULIKOWSKI, Daniel Jason URBAN, Shyh Ming YANG
  • Publication number: 20220111385
    Abstract: Blood sample collection and processing system (1) using a tube (102) and a holder (104) is described herein. The tube (102) includes a plasma separation system (114) for converting a whole blood sample into a plasma sample without using centrifugation. The plasma separation system (114) may comprise a microfluidic separation system such as a lateral cavity acoustic transducer system (113). The tube (102) is thereafter placed in the holder (104) for analysis regarding the plasma. The results of the analysis may be displayed to the user via a display screen (134) or an indicator of a different kind, to allow the user to determine whether the sample is sufficient with regards to volume, and/or quality for further use. Inasmuch as the analysis system (132) performs a rapid analysis of the plasma sample, the patient is still present and if the sample is insufficient, the healthcare provider can take another whole blood sample, counsel the client regarding the blood sample, or examine the patient further.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 14, 2022
    Inventors: David L. YANG, Fiona S. ADAIR, Dirk HECKEL
  • Publication number: 20210015414
    Abstract: Blood sample collection and processing system (1) using a tube (102) and a holder (104) is described herein. The tube (102) includes a plasma separation system (114) for converting a whole blood sample (129) into a plasma sample without using centrifugation. The plasma separation system (114) may comprise a filtration system such as a hollow fiber element (115). The tube (102) is thereafter placed in the holder (104) for analysis regarding the plasma. The results of the analysis may be displayed to the user via a display screen (134) to allow the user to determine whether the sample is sufficient for further use. Inasmuch as the analysis system (132) performs a rapid analysis of the plasma sample, the patient may still be present or in close proximity and if the sample is insufficient, the healthcare provider can take another whole blood sample (129), counsel the client regarding the blood sample (129), or examine the patient further.
    Type: Application
    Filed: July 17, 2020
    Publication date: January 21, 2021
    Inventors: David L. YANG, Fiona S. ADAIR, Dirk HECKEL
  • Publication number: 20150217291
    Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
    Type: Application
    Filed: January 6, 2015
    Publication date: August 6, 2015
    Inventors: Brian D. Wilson, Sami D. ALARURI, Matthew S. DAVIS, Matthew D. ERICKSON, Alan N. JOHNSON, Garrick A. MAURER, Mark F. SAUERBURGER, Daniel R. SCHMIDT, Joshua D. WILTSIE, Thomas M. STACHELEK, David L. YANG
  • Patent number: 8962308
    Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: February 24, 2015
    Assignee: Beckman Coulter, Inc.
    Inventors: Brian D. Wilson, Sami D. Alaruri, Matthew S. Davis, Matthew D. Erickson, Alan N. Johnson, Garrick A. Maurer, Mark F. Sauerburger, Daniel R. Schmidt, Joshua D. Wiltsie, Thomas M. Stachelek, David L. Yang
  • Patent number: 7518727
    Abstract: A system for detecting electromagnetic radiation from samples comprising: a plurality of sample volumes, each of said sample volumes confined within a portion of a capillary column; a plurality of electromagnetic radiation sources; a mirror for receiving electromagnetic radiation from the electromagnetic radiation sources and for reflecting the electromagnetic radiation to the sample volumes; a scanner attached to the mirror; a parabolic reflector for collecting sample electromagnetic radiation from the sample volumes, the sample electromagnetic radiation being generated as a result of interaction of the reflected electromagnetic radiation with the sample volumes; a plurality of filters for filtering the sample electromagnetic radiation; and a plurality of detectors for detecting sample electromagnetic radiation from the sample volumes, each of the detectors being configured to receive sample electromagnetic radiation that has passed through a corresponding one of the plurality of filters and generate a signa
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: April 14, 2009
    Assignee: Beckman Coulter, Inc.
    Inventors: Stephen L. Pentoney, Jr., David L. Yang
  • Publication number: 20080203319
    Abstract: A system for detecting electromagnetic radiation from samples comprising: a plurality of sample volumes, each of said sample volumes confined within a portion of a capillary column; a plurality of electromagnetic radiation sources; a mirror for receiving electromagnetic radiation from the electromagnetic radiation sources and for reflecting the electromagnetic radiation to the sample volumes; a scanner attached to the mirror; a parabolic reflector for collecting sample electromagnetic radiation from the sample volumes, the sample electromagnetic radiation being generated as a result of interaction of the reflected electromagnetic radiation with the sample volumes; a plurality of filters for filtering the sample electromagnetic radiation; and a plurality of detectors for detecting sample electromagnetic radiation from the sample volumes, each of the detectors being configured to receive sample electromagnetic radiation that has passed through a corresponding one of the plurality of filters and generate a signa
    Type: Application
    Filed: February 28, 2007
    Publication date: August 28, 2008
    Inventors: Stephen L. Pentoney, David L. Yang
  • Patent number: 7179357
    Abstract: The invention is a method of performing electrophoresis that increases sample throughput and increases the efficiency and speed of the analysis of polynucleotides by electrophoresis. The method is performed by loading and running multiple sequential samples on each capillary gel without flushing or replacing the gel between samples.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: February 20, 2007
    Assignee: Beckman Coulter, Inc.
    Inventors: Clarence Lew, Stephen L. Pentoney, Jr., David L. Yang
  • Publication number: 20040079640
    Abstract: The invention is a method of performing electrophoresis that increases sample throughput and increases the efficiency and speed of the analysis of polynucleotides by electrophoresis. The method is performed by loading and running multiple sequential samples on each capillary gel without flushing or replacing the gel between samples.
    Type: Application
    Filed: October 25, 2002
    Publication date: April 29, 2004
    Inventors: Clarence Lew, Stephen L. Pentoney, David L. Yang