Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for designing proteins. In one aspect, a method comprises: generating noisy molecular structure data sampled from a noise distribution that defines, for each position in an amino acid sequence of the protein, a corresponding initial spatial position for each atom in a predefined set of possible atoms; and processing the noisy molecular structure data using a diffusion model that comprises a denoising neural network to generate denoised molecular structure data that defines a denoised version of the noisy molecular structure data.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for designing a protein by jointly generating an amino acid sequence and a structure of the protein. In one aspect, a method comprises: generating data defining the amino acid sequence and the structure of the protein using a protein design neural network, comprising, for a plurality of positions in the amino acid sequence: receiving the current representation of the protein as of the current position: processing the current representation of the protein using the protein design neural network to generate design data for the current position that comprises: (i) data identifying an amino acid at the current position, and (ii) a set of structure parameters for the current position; and updating the current representation of the protein using the design data for the current position.

Abstract: Disclosed herein are polypeptides that bind to the hemagglutinin protein of influenza virus, and which can be used for treating and diagnosing influenza infection.

Abstract: Disclosed herein are polypeptides that bind to the hemagglutinin protein of influenza virus, and which can be used for treating and diagnosing influenza infection.

Abstract: An apparatus for cooling fish on board a ship is provided. This apparatus includes an ice-making machine for producing fine particles of ice in a brine solution. Coupled to this ice-making machine are means for directing ice from the machine to either a vessel containing brine solution or to a catch of fish. A method of cooling fish comprising producing a slurry of fine particles in brine solution in an ice-making zone and directing the fine ice particles onto either a catch of fish or into a vessel containing brine solution is also provided.