Abstract: The present disclosure provides a vitreous visualization system including a general light source, a general conduit that transmits light from the general light source through a conduit portion of a general illumination optical fiber, and a combined vitreous visualization and general illumination tool that receives light from the general conduit. The combined vitreous visualization tool includes a vitreous visualization light source, a controller for the vitreous visualization light source, a vitreous visualization optical fiber, a tool portion of the general illumination optical fiber, and a probe tip through which at least parts of both the vitreous visualization optical fiber and the tool portion of the general illumination optical fiber pass.

Abstract: The present disclosure provides a system and method for monitoring phototoxicity caused by vitreous visualization device (“VVD”) illumination during ophthalmic surgery. The systems and methods determine the cumulative amount of optical energy incident on the retina, which corresponds to phototoxicity, the distance between a cutter of the VVD and the retina, and areas where the vitreous has been removed, or any combination thereof. The disclosure further provides a method for monitoring and preventing phototoxicity caused by VVD illumination during ophthalmic surgery. The method may further include determining the distance between a cutter of the VVD and the retina, and determining areas where the vitreous has been removed based on focus areas of the retina that the plurality of light spots has contacted.

Abstract: Devices and methods are provided for injection of a therapeutic agent into an area beneath eye tissue, such as a sub-retinal area or a suprachoroidal area. Example devices comprise an injector housing, a tubular element (needle or microcatheter), a first area within the injector housing configured to be selectively in fluid communication with the tubular element for delivery of a bleb-formation fluid, and a second area within the injector housing configured to be selectively in fluid communication with the tubular element for delivery of a therapeutic agent into the area beneath eye tissue. In some embodiments, the first area is a chamber within the injector housing, and the second area is an internal area of a tube within the chamber. The devices and methods allow, with a single needle (or microcatheter) insertion, high pressure bleb formation and low pressure delivery of fragile therapeutic agent compositions.

Abstract: The present disclosure provides a system and method for monitoring phototoxicity caused by vitreous visualization device (“VVD”) illumination during ophthalmic surgery. The systems and methods determine the cumulative amount of optical energy incident on the retina, which corresponds to phototoxicity, the distance between a cutter of the VVD and the retina, and areas where the vitreous has been removed, or any combination thereof. The disclosure further provides a method for monitoring and preventing phototoxicity caused by VVD illumination during ophthalmic surgery. The method may further include determining the distance between a cutter of the VVD and the retina, and determining areas where the vitreous has been removed based on focus areas of the retina that the plurality of light spots has contacted.

Abstract: The present disclosure provides a vitreous visualization system including a general light source, a general conduit that transmits light from the general light source through a conduit portion of a general illumination optical fiber, and a combined vitreous visualization and general illumination tool that receives light from the general conduit. The combined vitreous visualization tool includes a vitreous visualization light source, a controller for the vitreous visualization light source, a vitreous visualization optical fiber, a tool portion of the general illumination optical fiber, and a probe tip through which at least parts of both the vitreous visualization optical fiber and the tool portion of the general illumination optical fiber pass.

Abstract: The invention is related to the use of one or several digital signatures obtained from at least one structural characteristic of a material element that has a complex, chaotic, unique and stable structure, to protect the direct reading of sensitive data, a media of such protected data and a method for reading this protected data.

Abstract: The invention relates to a method for acceptance of a candidate fibrous medium comprising the following steps: a candidate digital signature is generated from a structural characteristic extracted from a reference zone of the fibrous medium, the said digital signature representing the unique, complex, chaotic structure of the reference zone, practically invariable with time; the candidate digital signature is compared with at least one authentic digital signature previously recorded on a digital data medium so as to issue a positive or negative decision about acceptance of the candidate fibrous medium; characterized in that the comparison uses a statistical method to calculate a similarity index between the candidate digital characteristic and the authentic digital signature, and to compare this similarity index with a given acceptance threshold, so as to enable issuing a positive acceptance decision if the candidate digital signature does not exactly correspond to the authentic digital signature with whi

Abstract: The invention is related to the use of one or several digital signatures obtained from at least one structural characteristic of a material element that has a complex, chaotic, unique and stable structure, to protect the direct reading of sensitive data, a media of such protected data and a method for reading this protected data.

Abstract: The invention relates to a method for acceptance of a candidate fibrous medium comprising the following steps: a candidate digital signature is generated from a structural characteristic extracted from a reference zone of the fibrous medium, the said digital signature representing the unique, complex, chaotic structure of the reference zone, practically invariable with time; the candidate digital signature is compared with at least one authentic digital signature previously recorded on a digital data medium so as to issue a positive or negative decision about acceptance of the candidate fibrous medium; characterised in that the comparison uses a statistical method to calculate a similarity index between the candidate digital characteristic and the authentic digital signature, and to compare this similarity index with a given acceptance threshold, so as to enable issuing a positive acceptance decision if the candidate digital signature does not exactly correspond to the authentic digital signature with which i