Patents by Inventor David LaFleur

David LaFleur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BChE ALBUMIN FUSIONS FOR THE TREATMENT OF COCAINE ABUSE
    Publication number: 20110312900
    Abstract: A method of attenuating a biological effect of cocaine exposure in a primate. Such method includes administering to the primate an amount of a BChE-albumin fusion protein comprising the amino acid substitutions A227S, S315G, A356W, and Y360G, wherein the amount of the fusion protein is effective to cause attenuation of the biological effect of cocaine exposure in the primate.
    Type: Application
    Filed: December 7, 2010
    Publication date: December 22, 2011
    Inventors: Liora Sklair-Tavron, Moti Rosenstock, Liron Shemesh-Darvish, Hussein Hallak, Victor Piryatinsky, Viktor Roschke, David Lafleur
  • Albumin Fusion Proteins
    Publication number: 20110002888
    Abstract: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
    Type: Application
    Filed: June 3, 2010
    Publication date: January 6, 2011
    Inventors: Craig A. Rosen, Adam Bell, Paul A. Moore, Yanggu Shi, David Lafleur, Jason B. Bock, Michael W. Laird, William A. Haseltine, Douglas B. Woods, Mani Subramanian
  • Methods of Treating Fungal Infections
    Publication number: 20100130450
    Abstract: Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators are disclosed.
    Type: Application
    Filed: May 5, 2008
    Publication date: May 27, 2010
    Applicant: NORTHEASTERN UNIVERSITY
    Inventors: Kim Lewis, Michael David Lafleur
  • Albumin Fusion Proteins
    Publication number: 20080194481
    Abstract: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
    Type: Application
    Filed: October 31, 2007
    Publication date: August 14, 2008
    Inventors: Craig A. Rosen, Adam Bell, Paul A. Moore, Yanggu Shi, David LaFleur, Jason B. Bock, Michael W. Laird, William A. Haseltine, Douglas B. Woods, Mani Subramanian
  • 98 Human Secreted Proteins
    Publication number: 20080051338
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 12, 2007
    Publication date: February 28, 2008
    Applicant: Human Genome Sciences, Inc.
    Inventors: George Komatsoulis, Craig Rosen, Steven Ruben, Roxanne Duan, Paul Moore, Yanggu Shi, David LaFleur, Ying-Fei Wei, Jian Ni, Kimberly Florence, Paul Young, Laurie Brewer, Daniel Soppet, Gregory Endress, Reinhard Ebner, Henrik Olsen, Michael Mucenski
  • 36 Human Secreted Proteins
    Publication number: 20080020969
    Abstract: The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: July 20, 2007
    Publication date: January 24, 2008
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Daniel Soppet, Henrik Olsen, Steven Ruben, Jian Ni, Craig Rosen, Laurie Brewer, Roxanne Duan, Reinhard Ebner
  • Albumin fusion proteins
    Publication number: 20080004206
    Abstract: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
    Type: Application
    Filed: July 31, 2006
    Publication date: January 3, 2008
    Inventors: Craig Rosen, Adam Bell, Paul Moore, Yanggu Shi, David LaFleur, Jason Bock, Michael Laird, William Haseltine, Douglas Woods, Mani Subramanian
  • ANTIBODIES TO HHPEN62 POLYPEPTIDE
    Publication number: 20070172830
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: May 21, 2004
    Publication date: July 26, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Kimberly Florence, Jian Ni, Craig Rosen, Kenneth Carter, Paul Moore, Henrik Olsen, Yanggu Shi, Paul Young, Ying-Fei Wei, Laurie Brewer, Daniel Soppet, David LaFleur, Gregory Endress, Reinhard Ebner, Charles Birse
  • 87 Human Secreted Proteins
    Publication number: 20070154912
    Abstract: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 4, 2006
    Publication date: July 5, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Young, John Greene, Ann Ferrie, Steven Ruben, Craig Rosen, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Paul Moore, Yanggu Shi, David LaFleur, Jian Ni
  • 44 Human Secreted Proteins
    Publication number: 20070154918
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 11, 2006
    Publication date: July 5, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
  • 50 Human Secreted Proteins
    Publication number: 20070154910
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further re lates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: December 1, 2006
    Publication date: July 5, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Moore, Steven Ruben, David LaFleur, Yanggu Shi, Craig Rosen, Henrik Olsen, Reinhard Ebner, Laurie Brewer
  • Albumin fusion proteins
    Publication number: 20070048282
    Abstract: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
    Type: Application
    Filed: August 8, 2006
    Publication date: March 1, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig Rosen, William Haseltine, Paul Moore, Jason Bock, Adam Bell, Yanggu Shi, David LaFleur
  • 94 human secreted proteins
    Publication number: 20070020724
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 9, 2004
    Publication date: January 25, 2007
    Inventors: Steven Ruben, Jian Ni, Craig Rosen, Ying-Fei Wei, Paul Young, Kimberly Florence, Daniel Soppet, Laurie Brewer, Gregory Endress, Kenneth Carter, Michael Mucenski, Reinhard Ebner, David LaFleur, Henrik Olsen, Yanggu Shi, Paul Moore, George Komatsoulis
  • 71 human secreted proteins
    Publication number: 20070014787
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: March 15, 2006
    Publication date: January 18, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, George Komatsoulis, D. Duan, Craig Rosen, Paul Moore, Yanggu Shi, David LaFleur, Reinhard Ebner, Henrik Olsen, Laurie Brewer, Kimberly Florence, Paul Young, Michael Mucenski, Gregory Endress, Daniel Soppet
  • 123 human secreted proteins
    Publication number: 20070015908
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 15, 2004
    Publication date: January 18, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Carrie Fischer, Craig Rosen, Daniel Soppet, Steven Ruben, Hla Kyaw, Yi Li, Zhizhen Zeng, David LaFleur, Paul Moore, Yanggu Shi, Henrik Olsen, Reinhard Ebner, Charles Birse
  • 44 human secreted proteins
    Publication number: 20060281095
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 3, 2004
    Publication date: December 14, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
  • 207 human secreted proteins
    Publication number: 20060223077
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 20, 2005
    Publication date: October 5, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reinhard Ebner, David LaFleur, Paul Moore, Henrik Olsen, Craig Rosen, Steven Ruben, Daniel Soppet, Paul Young, Yanggu Shi, Kimberly Florence, Ying-Fei Wei, Charles Florence, Jing-Shan Hu, Yi Li, Hla Kyaw, Carrie Fischer, Ann Ferrie, Ping Fan, Ping Feng, Gregory Endress, Patrick Dillon, Kenneth Carter, Laurie Brewer, Guo-Liang Yu, Zhizhen Zeng, John Greene
  • 186 human secreted proteins
    Publication number: 20060084082
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 6, 2005
    Publication date: April 20, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, D. Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Carrie Fischer, Reinhard Ebner, Laurie Brewer, Paul Moore, Yanggu Shi, David LaFleur, Yi Li, ZhiZhen Zeng, Hla Kyaw
  • 98 human secreted proteins
    Publication number: 20060079670
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 20, 2005
    Publication date: April 13, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: George Komatsoulis, Craig Rosen, Steven Ruben, Roxanne Duan, Paul Moore, Yanggu Shi, David LaFleur, Ying-Fei Wei, Jian Ni, Kimberly Florence, Paul Young, Laurie Brewer, Daniel Soppet, Gregory Endress, Reinhard Ebner, Henrik Olsen, Michael Mucenski
  • 33 human secreted proteins
    Publication number: 20060036089
    Abstract: The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 3, 2005
    Publication date: February 16, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Daniel Soppet, Paul Moore, Yanggu Shi, Steven Ruben, Craig Rosen, David LaFleur, Henrik Olsen, Reinhard Ebner, Kimberly Florence, Paul Young, George Komatsoulis, Jian Ni