Abstract: Disclosed are compositions of matter and therapeutic means for increasing efficacy of immunotherapy such as Tumor Infiltrating Lymphocytes (TILs), Chimeric Antigen Receptor (CAR)-T cells, and other cellular therapies in solid tumors. In one embodiment agents capable of increasing tumor immunogenicity and/or antigen presentation by modulation of tumor stromal cells such as monocytes and pericytes are administered prior to providing immunotherapy in a patient. In some embodiments administration of interleukin-33 together with one or more antioxidants is provided as a means of stimulating expression of HLA and TAP proteins without inducing significant inflammatory response and myeloid derived suppressor cell activation in cancer associated monocytes. In other embodiments the use of histone deacetylase (HDAC) inhibitors together with interferon alpha is disclosed as a means of stimulating the expression of immunogenic molecules on monocytes to increase immunotherapy cell activity.

Abstract: Disclosed are means, methods and compositions of matter useful for stimulation enhancement of T cell homing into tumors and overcoming tumor microenvironment. In one embodiment the invention provides an engineered T cell in which engagement of T cell receptor on said T cell results in upregulation of T cell attracting chemokines so as to induce an increased proportion of T cells to tumor cells. In another embodiment, T cell chemokine secreting cells are administrated intratumorally in order to augment T cell infiltration into said tumors. In other embodiments administration of lymphopoietic cytokines is performed intratumorally to enhance viability of T cells approaching and residing in the microenvironment. Combinations of agents which counteract tumor microenvironment induced immune suppression are also disclosed.

Abstract: Disclosed are aptamers designed to bind immunological checkpoint molecules while concurrently suppressing tumor associated gene expression through delivery of DNA molecules encoding short hairpin DNA. In one embodiment the invention provides an aptamer capable of binding PD-1 and/or PD-1 ligand while concurrently possessing ability to induce RNA interference to one more multiple other immune inhibitory and/or oncogenesis related genes. In one embodiment such a dual-targeting aptamer is utilized to induce systemic tumor abscopal effect.

Abstract: Disclosed are combination therapies for cancer utilizing the leverage of the adaptive immune system through chimeric antigen receptor (CAR) T cells, combined with leveraging the innate immune system by using CAR-macrophages (CAR-M) and CAR-natural killer (NK) cells. In some embodiments, the invention teaches the initial modification of the tumor microenvironment by administration of CAR-M and CAR-NK. The alteration of the tumor microenvironment results in reduction of barriers for CAR-T cells to enter the tumor, which allows for efficacy of CAR-T in treatment of solid tumors. In some embodiments adjuvant immunotherapies are utilized to expand immunological attack such as addition of complement, immunotherapeutic antibodies, chemotherapy and radiotherapy approaches.

Abstract: A method, computer program product, and system to perform a sale transaction are provided. The method includes identifying each item of a plurality of items, based on at least one image of the plurality of items, determining a cost for each item, optionally identifying a person based on an image of the person, adding each of the items and each of the costs to a sale transaction, and charging the person for the sale transaction.

Abstract: A method, computer program product, and system are disclosed for compiling a virtual transaction for a person within an environment having a plurality of items. The method includes acquiring, using at least one visual sensor, first image information including a person. The method further includes identifying the at least one person from the first image information by classifying the person into a class. The method also includes acquiring second image information including the person and an item. The method further includes identifying a behavior of the person relative to the item, and updating, based on the identified behavior, the virtual transaction.

Abstract: A method, computer program product, and system to perform a sale transaction are provided. The method includes identifying each item of a plurality of items, based on at least one image of the plurality of items, determining a cost for each item, optionally identifying a person based on an image of the person, adding each of the items and each of the costs to a sale transaction, and charging the person for the sale transaction.

Abstract: A method, computer program product, and system to perform a sale transaction are provided. The method includes identifying each item of a plurality of items, based on at least one image of the plurality of items, determining a cost for each item, optionally identifying a person based on an image of the person, adding each of the items and each of the costs to a sale transaction, and charging the person for the sale transaction.

Abstract: To provide a user with descriptive images for each function performed by a button, the embodiments described herein use a transforming graphical expression that presents different images depending on the particular function the button is currently performing. For example, if the button is used to increase speaker volume, the graphical expression may display plus sign, but if the button is currently being used to navigate through a display menu, the graphical expression may be transformed into an arrow to indicate the direction a selection element in the menu moves if the button is activated. Thus, as the current function of the button changes, the graphical expression presented to the user also changes. In this manner, the same button may be used to perform multiple functions while presenting to a user a customized graphical expression indicating the current function of the button.

Abstract: A method, computer program product, and system are disclosed for facilitating access by a first person to a secure region that is at least partly defined by an access control device. The method acquires, using at least one visual sensor, first image information including the first person and the access control device. The method identifies the first person using image analysis performed on the first image information. The method further identifies a first behavior of the first person relative to the access control device. Upon determining the first behavior corresponds to a predefined visual access behavior indicating that the first person is in the process of manually operating the access control device, and that the security level of the first person satisfies a predetermined threshold security level associated with the access control device, the method permits the first person to physically access the secure region.

Abstract: A method, computer program product, and system to perform a sale transaction are provided. The method includes identifying each item of a plurality of items, based on at least one image of the plurality of items, determining a cost for each item, optionally identifying a person based on an image of the person, adding each of the items and each of the costs to a sale transaction, and charging the person for the sale transaction.

Abstract: A method, computer program product, and system to perform a sale transaction are provided. The method includes identifying each item of a plurality of items, based on at least one image of the plurality of items, determining a cost for each item, optionally identifying a person based on an image of the person, adding each of the items and each of the costs to a sale transaction, and charging the person for the sale transaction.

Abstract: A method, computer program product, and system are disclosed for facilitating access by a first person to a secure region that is at least partly defined by an access control device. The method acquires, using at least one visual sensor, first image information including the first person and the access control device. The method identifies the first person using image analysis performed on the first image information. The method further identifies a first behavior of the first person relative to the access control device. Upon determining the first behavior corresponds to a predefined visual access behavior indicating that the first person is in the process of manually operating the access control device, and that the security level of the first person satisfies a predetermined threshold security level associated with the access control device, the method permits the first person to physically access the secure region.

Abstract: A portable payment terminal (PPT) that is used to facilitate customer transactions in a mobile point-of-sale (MPOS) system is assigned to a particular tablet device. The PPT device may dock with to charge its batteries, and undock from the tablet device to facilitate customer transactions. To maintain a requisite one-to-one relationship between the two devices, a timer is started whenever the PPT device is undocked from the tablet device. Additionally, checks are performed to ensure that the PPT device is authorized to dock with the tablet device. If the PPT device remains undocked from the tablet device for a predetermined time period, or if the PPT device is not authorized to dock with the tablet device, the functions of the tablet device and/or the PPT device are disabled to reduce or eliminate the usability of the devices to a user.

Abstract: A network of cameras is disposed throughout a store, such as a grocery store, for example. The cameras are positioned so as to monitor the products available in the store, as well as the entrances and exits to and from the store. Customers are identified as they enter the store, and their movements throughout the store are tracked. The cameras capture images of the products selected by the customer and then send those images to a computer server. The server identifies each product selected by the customer, maintains a total price for all products selected by the customer, and automatically debits the customer's account for the total price upon detecting the customer leaving the store.

Abstract: A method, computer program product, and system are disclosed for facilitating access by a first person to a secure region within an environment having a plurality of items, wherein the secure region is at least partly defined by an access control device. The method acquires, using at least one visual sensor disposed within the environment, first image information including the first person and the access control device. The method identifies the first person using image analysis performed on the first image information. Further, the method identifies, using image analysis a first behavior of the first person relative to the access control device. Upon determining the first behavior corresponds to a predefined visual access behavior, and the security level of the first person satisfies a predetermined threshold security level associated with the access control device, deactivating a security element to permit the first person to physically access the secure region.

Abstract: A method, computer program product, and system are disclosed for facilitating access by a first person to a secure region within an environment having a plurality of items, wherein the secure region is at least partly defined by an access control device. The method acquires, using at least one visual sensor disposed within the environment, first image information including the first person and the access control device. The method identifies the first person using image analysis performed on the first image information. Further, the method identifies, using image analysis a first behavior of the first person relative to the access control device. Upon determining the first behavior corresponds to a predefined visual access behavior, and the security level of the first person satisfies a predetermined threshold security level associated with the access control device, deactivating a security element to permit the first person to physically access the secure region.

Abstract: A method, computer program product, and system are disclosed for compiling a virtual transaction for a person within an environment having a plurality of items. The method includes acquiring, using at least one visual sensor, first image information including a person. The method further includes identifying the at least one person from the first image information by classifying the person into a class. The method also includes acquiring second image information including the person and an item. The method further includes identifying a behavior of the person relative to the item, and updating, based on the identified behavior, the virtual transaction.

Abstract: To provide a user with descriptive images for each function performed by a button, the embodiments described herein use a transforming graphical expression that presents different images depending on the particular function the button is currently performing. For example, if the button is used to increase speaker volume, the graphical expression may display plus sign, but if the button is currently being used to navigate through a display menu, the graphical expression may be transformed into an arrow to indicate the direction a selection element in the menu moves if the button is activated. Thus, as the current function of the button changes, the graphical expression presented to the user also changes. In this manner, the same button may be used to perform multiple functions while presenting to a user a customized graphical expression indicating the current function of the button.

Abstract: To provide a user with descriptive images for each function performed by a button, the embodiments described herein use a transforming graphical expression that presents different images depending on the particular function the button is currently performing. For example, if the button is used to increase speaker volume, the graphical expression may display plus sign, but if the button is currently being used to navigate through a display menu, the graphical expression may be transformed into an arrow to indicate the direction a selection element in the menu moves if the button is activated. Thus, as the current function of the button changes, the graphical expression presented to the user also changes. In this manner, the same button may be used to perform multiple functions while presenting to a user a customized graphical expression indicating the current function of the button.