Abstract: A prosthetic knee provides security and stability, particularly to low activity users, household and limited community ambulators, single and/or slow speed ambulators, and those with little voluntary control, while also balancing walking (dynamic) performance for low activity users. The prosthetic knee includes a housing, parallel anterior links, a posterior link, and a chassis. The geometry of the links and their relationship to one another allow for low voluntary control, shortening of mid-swing, which reduces stumbling risk, and geometric stability in stance. The anterior links are particularly oriented, sized and located to provide for stability. The anterior links both extend above the posterior link and substantially below the posterior link. The prosthetic knee includes a friction adjustment mechanism, a stability adjustment mechanism, and an adjustable extension assist mechanism.

Abstract: A high torque active mechanism for an orthotic and/or prosthetic joint using a primary brake which can be provide by magnetorheological (MR) rotational damper incorporating and an additional friction brake mechanism driven by the braking force generated by the MR damper. This combination of MR damper and friction brake mechanism allows an increase in torque density while keeping the same level of motion control offered by the MR damper alone. The increased torque density achieved by this high torque active mechanism allows to minimize the size of the actuating system, i.e. its diameter and/or breath, while maximizing its braking torque capability. In this regard, the friction brake mechanism is advantageously positioned around the MR damper, such that the dimension of the package is minimized.

Abstract: Methods are provided for determining stereochemistry for a component of a composition where the composition includes a glycosaminoglycan (GAG) where the method includes (a) cleaving the GAG with a lyase; (b) separating the products of the cleaved GAG by chromatography in the presence of one or more solvents wherein at least one solvent comprises an organic acid or organic acid derivative in an amount of no more than 50% v/v of solvent; and determining the stereochemistry of the component.

Abstract: A method of sensing ground contact with a lower limb prosthetic or orthotic device is provided. A first translational displacement between a frame and a connector can be sensed and then processed to identify an axial load caused by heel-ground contact. Additionally, a second translational displacement between the frame and the connector can be sensed and then processed to identify a torsional load caused by toe-ground contact.

Abstract: A high torque active mechanism for an orthotic and/or prosthetic joint using a primary brake which can be provide by magnetorheological (MR) rotational damper incorporating and an additional friction brake mechanism driven by the braking force generated by the MR damper. This combination of MR damper and friction brake mechanism allows an increase in torque density while keeping the same level of motion control offered by the MR damper alone. The increased torque density achieved by this high torque active mechanism allows to minimize the size of the actuating system, i.e. its diameter and/or breath, while maximizing its braking torque capability. In this regard, the friction brake mechanism is advantageously positioned around the MR damper, such that the dimension of the package is minimized.

Abstract: Embodiments of the invention provide methods for effecting a desired business solution. In accordance with one embodiment of the invention, a plurality of aspects of a business are analyzed. Each aspect corresponds to an element of a particular domain of a set of domains wherein the plurality of aspects corresponds to elements from at least two domains. A modification of each element that will result in a desired outcome in regard to the corresponding aspect is determined. In accordance with one embodiment of the invention, the business solution development process identifies and provides exit criteria pertaining to each stage of the business solution development process. For one embodiment of the invention a set of metrics are defined and tracked to measure the effectiveness of the business solution.

Abstract: Disclosed herein a prosthetic or orthotic device having a joint portion and a compliant transmission assembly in operational communication with the joint portion. The device restores the normal capabilities and natural dynamics of a healthy joint for common activities. The compliant transmission assembly includes a compliant element. The compliant transmission assembly absorbs energy when a torque is applied. between a prosthetic or orthotic device portion and another adjacent device portion or the adjacent limb segment, of the user. The compliant element of the invention absorbs energy during flexion of a joint for the dampening thereof and releases this energy during extension of the joint for assistance thereof. Also disclosed herein is an actuator assembly, a torque sensor and an actuator locking device as well as a method for determining the torque of such prosthetic and orthotic devices.

Abstract: Embodiments of the invention provide methods for effecting a desired business solution. In accordance with one embodiment of the invention, a plurality of aspects of a business are analyzed. Each aspect corresponds to an element of a particular domain of a set of domains wherein the plurality of aspects corresponds to elements from at least two domains. A modification of each element that will result in a desired outcome in regard to the corresponding aspect is determined. In accordance with one embodiment of the invention, the business solution development process identifies and provides exit criteria pertaining to each stage of the business solution development process. For one embodiment of the invention a set of metrics are defined and tracked to measure the effectiveness of the business solution.

Abstract: Substantially pure glycosidases capable for cleaving selected glycosidic bonds have been described including glycosidases isolated from Xanthomonas and recombinant glycosidases. Substrate specificity of isolated enzymes have been identified for GlcNac?1-x, Gal?1-3R, Gal?1-6R, Gal?1-3R, Fuc?-2R, Fuc?1-3R, Fuc?1-4R, Man?1-2R, Man?1-3R, Man?1-6R, Man?1-4R, Xyl?1-2R, Glc?1-4R, and Gal?1-4R providing improved capability for selectively cleaving a glycosidic linkage in a carbohydrate substrate and for forming modified carbohydrates.

Abstract: A business solution development process having one or more pre-definition stages and one or more post-deployment stages is disclosed. In accordance with one embodiment of the invention, data pertinent to an understanding of a business is analyzed and a future state of the business is envisioned. One or more desired outcomes necessary to attaining the envisioned future state of the business are then determined. One or more transformations that will effect each desired outcome are determined and implemented to attain the envisioned future state of the business.

Abstract: The method includes receiving parameters input by a user and calculating crack behavior estimations based on the received parameters by using a plurality of accessible crack behavior models. The crack behavior estimations calculated from each of the models are displayed to the user in order to illustrate how the different models compare in calculating a desired crack behavior profile. The displayed crack behavior estimations utilize a compilation of both historical crack growth rate data, as well as predicted crack growth rate data, and may be displayed as an estimated crack growth rate versus time, or as estimated crack growth over time. These parameters are displayed graphically for each crack behavior model in order to enable the user to make a comparison for each crack growth model.

Abstract: A hand-held dental floss holder, dispenser, floss tensioning, and floss advancing device. The device is configured with one end being a handle and the other being a pair of tips across which dental floss is spanned for presenting to inter-dental spaces. An internal supply of dental floss is housed inside the handle. The floss passes from the supply, moves around floss guides, wraps one or more times around a free spooling clutch spool, exits the body of the device through an opening and is directed to and across the tips of the device and is guided back to a collection spool rotationally connected to a manually-activated one way thumbwheel. In a first position, the gearing of a gear assembly and an internal clutch spool assembly causes the floss to tension when the thumbwheel is turned. In a second position, the disengagement of gearing allows the clutch spool to spool freely, allowing fresh floss to be substituted for used floss, when the thumbwheel is turned.

Abstract: A method is provided for simultaneously developing caverns while depositing wastes or other materials in them. A well is first drilled into a salt formation and the development of a salt cavern by means of solution mining is initiated. When the development of the cavern has been carried out to an extent sufficient to accommodate the injection of a prescribed amount of wastes or other materials, injection of the wastes or other materials through the well is started while continuing to develop the cavern by solution mining. The injection of the wastes or other materials may be carried out continuously or intermittently. The proportion and rates of wastes or other materials and mining water injected into the well are monitored and regulated so that cavern development continues at a rate that allows the cavern to reach an intended prescribed size while the wastes or other materials are injected and deposited into the cavern.

Abstract: An integrated energy hub facility capable of bringing together all aspects of hydrocarbon and other fluid product movement under controlled conditions applicable to the reception, storage, processing, collection and transmission downstream is provided. Input to the energy hub includes natural gas and crude from a pipeline or a carrier, LNG from a carrier, CNG from a carrier, and carrier-regassed LNG, as well as other products from a pipeline or a carrier. Storage can be above surface, in salt caverns or in subterranean formations and cavities, and include petroleum crude, natural gas, LPG, NGL, GTL and other fluids. Transmission downstream may be carried out by a vessel or other type of carrier and/or by means of a pipeline system. Cryogenic fluids are offloaded and sent to the energy hub surface holding tank, then pumped to the energy hub vaporizers and sent to underground storage and/or distribution.

Abstract: The method includes receiving parameters input by a user and calculating crack behavior estimations based on the received parameters by using a plurality of accessible crack behavior models. The crack behavior estimations calculated from each of the models are displayed to the user in order to illustrate how the different models compare in calculating a desired crack behavior profile. The displayed crack behavior estimations utilize a compilation of both historical crack growth rate data, as well as predicted crack growth rate data, and may be displayed as an estimated crack growth rate versus time, or as estimated crack growth over time. These parameters are displayed graphically for each crack behavior model in order to enable the user to make a comparison for each crack growth model.

Abstract: In accordance with the present invention, there are provided substantially pure glycosidases obtainable from the genus Chryseobacterium. In particular, there is provided a substantially pure exo &agr;-N-Acetylgalactosaminidase from Chryseobacterium meningosepticum. A method of cloning this enzyme and producing a recombinant form of the enzyme is also provided by the present invention.

Abstract: Substantially pure glycosidases capable for cleaving selected glycosidic bonds have been described including glycosidases isolated from Xanthomonas and recombinant glycosidases. Substrate specificity of isolated enzymes have been identified for GlcNac&bgr;1-x, Gal&agr;1-3R, Gal&agr;1-6R, Gal&bgr;1-3R, Fuc&agr;-2R, Fuc&agr;1-3R, Fuc&agr;1-4R, Man&agr;1-2R, Man&agr;1-3R, Man&agr;1-6R, Man&bgr;1-4R, Xyl&bgr;1-2R, Glc&bgr;1-4R, and Gal&bgr;1-4R providing improved capability for selectively cleaving a glycosidic linkage in a carbohydrate substrate and for forming modified carbohydrates.

Abstract: In accordance with the present invention, there are provided substantially pure glycosidases obtainable from the genus Chryseobacterium. In particular, there is provided a substantially pure exo &agr;-N-Acetylgalactosaminidase from Chryseobacterium meningosepticum. A method of cloning this enzyme and producing a recombinant form of the enzyme is also provided by the present invention.

Abstract: In accordance with the present invention, there are provided substantially pure glycosidases obtainable from the genus Chryseobacterium. In particular, there is provided a substantially pure exo &agr;-N-Acetylgalactosaminidase from Chryseobacterium meningosepticum. A method of cloning this enzyme and producing a recombinant form of the enzyme is also provided by the present invention.

Abstract: Substantially pure glycosidases capable for cleaving selected glycosidic bonds have been described including glycosidases isolated from Xanthomonas and recombinant glycosidases. Substrate specificity of isolated enzymes have been identified for GlcNac&bgr;1-X, Gal&agr;1-3R, Gal&agr;1-6R, Gal&bgr;1-3R, Fuc&agr;-2R, Fuc&agr;1-3R, Fuc&agr;1-4R, Man&agr;1-2R, Man&agr;1-3R, Man&agr;1-6R, Man&bgr;1-4R, Xyl&bgr;1-2R, Glc&bgr;1-4R, and Gal&bgr;1-4R providing improved capability for selectively cleaving a glycosidic linkage in a carbohydrate substrate and for forming modified carbohydrates.