Patents by Inventor David Langan

David Langan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220273711
    Abstract: Disclosed am protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called die key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co-localized when bound to their targets, components of such protein switches, and their use.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 1, 2022
    Inventors: Scott BOYKEN, Marc Joseph LAJOIE, Robert A. LANGAN, David BAKER, Jilliane Ruth BRUFFEY
  • Publication number: 20220226485
    Abstract: The present disclosure provides a chimeric polypeptide comprising a helical bundle which comprises between about two and about seven alpha-helices and a bioactive peptide, wherein one or more of the alpha helices form one or more inter-helix hydrogen bonds and comprise at least one phosphorylation site and wherein the bioactive peptide is conformationally placed inside the helical bundle so that the bioactive peptide is not activated or exposed. The disclosure also provides a nucleotide sequence encoding the chimeric polypeptide, a vector comprising the nucleotide sequence, a cell comprising the nucleotide sequence, and method of making, using, or designing the chimeric polypeptide.
    Type: Application
    Filed: June 17, 2020
    Publication date: July 21, 2022
    Inventors: Nicholas WOODALL, Scott BOYKEN, Marc Joseph LAJOIE, Zibo CHEN, Robert A. LANGAN, David BAKER
  • Publication number: 20220218752
    Abstract: Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co/localized when bound to their targets, components of such protein switches, and their use.
    Type: Application
    Filed: May 18, 2020
    Publication date: July 14, 2022
    Inventors: David BAKER, Scott BOYKEN, Marc Joseph LAJOIE, Robert A. LANGAN, Stanley R. RIDDELL, Alexander SALTER
  • Patent number: 10847893
    Abstract: A reflector assembly configured to move between a stowed configuration and a deployed configuration includes a central hub, a series of ribs coupled to the central hub, and a flexible reflective material attached to the ribs. Each rib includes a root rib, an intermediate rib, and a tip rib. The root rib is configured to rotate in a first direction about a first axis away from a coaxial axis of the central hub, the intermediate rib is configured to rotate in the first direction about a second axis substantially parallel to the first axis, and the tip rib is configured to rotate in the first direction about a third axis substantially parallel to the second axis as the reflector assembly moves into the deployed configuration. The flexible reflective material and the ribs together form a reflective surface with a substantially paraboloidal surface profile configured to focus electromagnetic energy.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: November 24, 2020
    Assignee: Umbra Lab, Inc.
    Inventors: Gabe Dominocielo, David Langan
  • Publication number: 20190214737
    Abstract: A reflector assembly configured to move between a stowed configuration and a deployed configuration includes a central hub, a series of ribs coupled to the central hub, and a flexible reflective material attached to the ribs. Each rib includes a root rib, an intermediate rib, and a tip rib. The root rib is configured to rotate in a first direction about a first axis away from a coaxial axis of the central hub, the intermediate rib is configured to rotate in the first direction about a second axis substantially parallel to the first axis, and the tip rib is configured to rotate in the first direction about a third axis substantially parallel to the second axis as the reflector assembly moves into the deployed configuration. The flexible reflective material and the ribs together form a reflective surface with a substantially paraboloidal surface profile configured to focus electromagnetic energy.
    Type: Application
    Filed: January 4, 2019
    Publication date: July 11, 2019
    Inventors: Gabe Dominocielo, David Langan
  • Patent number: 7792241
    Abstract: A CT system includes a rotatable gantry having an opening for receiving an object to be scanned and an x-ray source coupled to the gantry and configured to project x-rays through the opening. The x-ray source includes a target, a first cathode configured to emit a first beam of electrons toward the target, a first gridding electrode coupled to the first cathode, a second cathode configured to emit a second beam of electrons toward the target, and a second gridding electrode coupled to the second cathode. The system includes a generator configured to energize the first cathode to a first kVp and to energize the second cathode to a second kVp, and a detector attached to the gantry and positioned to receive x-rays that pass through the opening.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: September 7, 2010
    Assignee: General Electric Company
    Inventors: Xiaoye Wu, David Langan, Colin R. Wilson, Yun Zou
  • Patent number: 7782998
    Abstract: A plurality of projection images are acquired over an angular range during the slow rotation of a C-arm gantry having a source and detector. Phase-specific reconstructions are generated from the plurality of projections, wherein each phase-specific reconstruction is generated generally from projections acquired at or near the respective phase. In one embodiment, a plurality of motion estimates are generated based upon the phase-specific reconstructions. One or more motion-corrected reconstructions may be generated using the respective motion estimates and projections. The motion-corrected reconstructions may be associated to form motion-corrected volume renderings.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: August 24, 2010
    Assignee: General Electric Company
    Inventors: David Langan, Peter Edic, Abdalmajeid Alyassin, Bernhard Claus, Joseph Manak, James V. Miller
  • Publication number: 20100104062
    Abstract: A CT system includes a rotatable gantry having an opening for receiving an object to be scanned and an x-ray source coupled to the gantry and configured to project x-rays through the opening. The x-ray source includes a target, a first cathode configured to emit a first beam of electrons toward the target, a first gridding electrode coupled to the first cathode, a second cathode configured to emit a second beam of electrons toward the target, and a second gridding electrode coupled to the second cathode. The system includes a generator configured to energize the first cathode to a first kVp and to energize the second cathode to a second kVp, and a detector attached to the gantry and positioned to receive x-rays that pass through the opening.
    Type: Application
    Filed: October 24, 2008
    Publication date: April 29, 2010
    Inventors: Xiaoye Wu, David Langan, Colin R. Wilson, Yun Zou
  • Publication number: 20070009088
    Abstract: An X-ray imaging system is provided. The X-ray imaging system includes a distributed X-ray source and a detector. The distributed X-ray source is configured to emit X-rays from a plurality of emission points arranged as a substantially linear segment, a substantially arcuate segment, a curvilinear segment, or a substantially non-planar surface and the detector is configured to generate a plurality of signals in response to X-rays incident upon the detector.
    Type: Application
    Filed: July 6, 2005
    Publication date: January 11, 2007
    Inventors: Peter Edic, Bernhard Claus, Jeffrey Eberhard, James Miller, David Langan, Mark Vermilyea, Joseph Manak, Christopher Unger
  • Patent number: 7149358
    Abstract: A method, system and computer readable medium for implementing and performing a multi-resolution contrast-based dynamic range management algorithm and allowing for the efficient compression of an intensity dynamic range of an input image to a reduced intensity dynamic range of an image display signal. Specifically, the method, system and computer readable medium of the invention comprise decomposing the input image into a plurality of image components, modifying the intensity characteristics of the plurality of image components and reconstructing the plurality of image components into an output image for display on an image display device. In another aspect of the method, system and computer readable medium of the invention, the decomposition of the input image and reconstruction into an output image are performed using a Laplacian pyramid.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: December 12, 2006
    Assignee: General Electric Company
    Inventor: David A. Langan
  • Publication number: 20060133564
    Abstract: A plurality of projection images are acquired over an angular range during the slow rotation of a C-arm gantry having a source and detector. Phase-specific reconstructions are generated from the plurality of projections, wherein each phase-specific reconstruction is generated generally from projections acquired at or near the respective phase. In one embodiment, a plurality of motion estimates are generated based upon the phase-specific reconstructions. One or more motion-corrected reconstructions may be generated using the respective motion estimates and projections. The motion-corrected reconstructions may be associated to form motion-corrected volume renderings.
    Type: Application
    Filed: December 21, 2004
    Publication date: June 22, 2006
    Inventors: David Langan, Peter Edic, Abdalmajeid Alyassin, Bernhard Claus, Joseph Manak, James Miller
  • Publication number: 20050135558
    Abstract: A technique is provided for generating a three-dimensional image from fluoroscopic projection images. The technique allows for the acquisition of fluoroscopic images at different perspectives relative to a region of interest. One or more three-dimensional images may then be reconstructed from the fluoroscopic projection images. The three-dimensional images may then be displayed to provide anatomic context for the fluoroscopic application. A fluoroscopic projection image, such as the most current fluoroscopic image, may be superimposed on the three-dimensional image if desired.
    Type: Application
    Filed: December 22, 2003
    Publication date: June 23, 2005
    Inventors: Bernhard Erich Claus, Jeffrey Eberhard, David Langan
  • Publication number: 20050074158
    Abstract: Some configurations of the present invention provide a method for locating a low contrast movable object coupled mechanically to a marker object in a series of image frames that include images of the low contrast object and the marker object. The method includes locating the marker object in a first selected frame of the series of image frames, selecting a patch of the first selected frame as a template of the marker object, and utilizing the template of the marker object to estimate a location of the marker object in a second selected frame of the series of image frames. The second selected frame is registered with the first selected frame utilizing the estimated location of the marker object in the second selected frame. The registered first selected frame and the second selected frame are fused to thereby enhance the contrast of the low contrast moveable object.
    Type: Application
    Filed: October 6, 2003
    Publication date: April 7, 2005
    Inventors: John Kaufhold, David Langan
  • Publication number: 20040101207
    Abstract: A method, system and computer readable medium for implementing and performing a multi-resolution contrast-based dynamic range management algorithm and allowing for the efficient compression of an intensity dynamic range of an input image to a reduced intensity dynamic range of an image display signal. Specifically, the method, system and computer readable medium of the invention comprise decomposing the input image into a plurality of image components, modifying the intensity characteristics of the plurality of image components and reconstructing the plurality of image components into an output image for display on an image display device. In another aspect of the method, system and computer readable medium of the invention, the decomposition of the input image and reconstruction into an output image are performed using a Laplacian pyramid.
    Type: Application
    Filed: November 27, 2002
    Publication date: May 27, 2004
    Applicant: GENERAL ELECTRIC COMPANY
    Inventor: David A. Langan
  • Patent number: 5578928
    Abstract: A method for detecting or sensing zero crossings in a rectified power signal comprising three separate signal constituents for energizing a three-phase circuit is provided. The method includes the steps of sampling at least two consecutive cycles of each signal constituent at a predetermined sampling rate; storing a predetermined number of samples for each signal constituent; computing a respective initial zero crossing estimate for each signal constituent; and checking the accuracy of the respective initial zero crossing estimate for each signal constituent of the power signal. If necessary, the method can further include the step of adjusting the initial estimate for the zero crossing of at least one of the three signal constituents of the power signal. In each case, the detected or sensed zero crossings, in turn, enable detection of a ground fault in the three phase circuit.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: November 26, 1996
    Assignee: General Electric Company
    Inventor: David A. Langan