Abstract: The present invention provides a highly scalable architecture for a three-dimensional graphical, multi-user, interactive virtual world system. In a preferred embodiment a plurality of users interact in the three-dimensional, computer-generated graphical space where each user executes a client process to view a virtual world from the perspective of that user. The virtual world shows avatars representing the other users who are neighbors of the user viewing the virtual word. In order that the view can be updated to reflect the motion of the remote user's avatars, motion information is transmitted to a central server process which provides positions updates to client processes for neighbors of the user at that client process. The client process also uses an environment database to determine which background objects to render as well as to limit the movement of the user's avatar.

Abstract: The invention relates to an improved process for preparing [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.

Abstract: The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).

Abstract: This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.

Abstract: A liquid personal cleansing composition comprising: (a) from about 1% to about 15% by weight of short chain alkyl sulphate surfactant having an average from 8 to 10 carbon atoms on the alkyl chain and mixtures thereof; (b) from about 1% to about 15% by weight of C.sub.12 to C.sub.22 alkyl ethoxy sulphate surfactant having an average degree of ethoxylation of from about 1 to about 6; (c) from about 0.1% to about 10% of water-soluble auxiliary surfactant selected from anionic surfactant other than C.sub.8 to C.sub.10 alkyl sulphate, nonionic, zwitterionic and amphoteric and mixtures thereof; and optionally (d) from about 0.01% to about 5% of cationic conditioning polymer; and (e) water; wherein the ratio of short chain alkyl sulphate to alkyl ethoxy sulphate is in the range of from about 1:3 to about 3:1, more preferably from about 2:1 to about 1:2.

Abstract: A liquid personal cleansing composition comprising: (a) from about 1% to about 15% by weight of short chain alkyl sulphate surfactant having an average of from 8 to 10 carbon atoms in the alkyl chain and mixtures thereof; (b) from about 1% to about 60% by weight of water-soluble auxiliary surfactant selected from anionic surfactant other than C.sub.8 to C.sub.10 alkyl sulphate, nonionic, zwitterionic and amphoteric surfactants and mixtures thereof; (c) from about 0.01% to about 5% by weight of cationic polymeric skin conditioning agent; and (d) water. The products demonstrate excellent in-use efficacy benefits including mildness, a moisturised skin feel, excellent rinsibility and good product stability and lather attributes.

Abstract: Cleansing and moisturizing personal cleansing compositions which contain from about 5% to about 50% of a surfactant; from about 3% to about 40% of an insoluble, nonionic oil or wax or mixture thereof; from about 0.1% to about 8% by weight of a fatty acid having an average chain length of from about 10 to about 18 carbon atoms; from about 1.5% to about 10% by weight of citric acid or water soluble citrate salt or mixture thereof; and water are disclosed.

Abstract: A liquid personal cleansing composition comprising: (a) from about 5% to about 60% by weight of water-soluble surfactant selected from anionic, nonionic and amphoteric surfactants and mixtures thereof; and (b) from about 0.01% to about 10% by weight of a hydrophobically modified nonionic cellulose ether selected from C.sub.14 -C.sub.18 alkyl and alkenyl modified, hydroxyethyl cellulose ethers having a degree of nonionic substitution in the range of from about 2.2 to about 2.8 and a degree of hydrophobic substitution in the range of from about 0.4% to about 0.6% by weight; and (c) water, and wherein the composition displays a shear stress of about 150 Pa at a shear rate in the range from about 400 s.sup.-1 to about 600 s.sup.-1 at 25.degree. C. The products demonstrate excellent in-use efficacy benefits including mildness, a moisturised skin feel, good rinsibility and good product stability.

Abstract: A liquid personal cleansing composition comprising: a) from about 5% to about 60% by weight of water-soluble surfactant selected from anionic, nonionic and amphoteric surfactants and mixtures thereof; b) from about 0.01% to about 10% by weight of a hydrophobically modified nonionic cellulose ether selected from C.sub.10 -C.sub.24 alkyl and alkenyl modified methyl, hydroxyethyl and hydroxypropyl cellulose ethers having a degree of nonionic substitution in the range of from about 1.8 to about 4 and a degree of hydrophobic substitution in the range of from about 0.1% to about 1% by weight; c) from about 0% to about 10% by weight of a water-soluble polyol; d) from about 0.01% to about 5% by weight of cationic polymeric skin conditioning agent; and e) water, and wherein the composition displays a shear stress of about 150 Pa at a shear rate in the range from about 100 s.sup.-1 to about 600 s.sup.-1 at 25.degree. C.