Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: A computer-implemented method of generating a reduction coping includes receiving a digital model comprising a virtual preparation tooth, determining one or more virtual reduction regions on the virtual preparation tooth, and generating a virtual reduction coping comprising one or more exposed regions corresponding to the one or more virtual reduction regions. A method of generating a physical reduction coping includes receiving a 3D digital model of a virtual reduction coping and performing additive manufacturing to generate a physical reduction coping from the virtual reduction coping.

Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: A computer-implemented method of generating a reduction coping includes receiving a digital model comprising a virtual preparation tooth, determining one or more virtual reduction regions on the virtual preparation tooth, and generating a virtual reduction coping comprising one or more exposed regions corresponding to the one or more virtual reduction regions. A method of generating a physical reduction coping includes receiving a 3D digital model of a virtual reduction coping and performing additive manufacturing to generate a physical reduction coping from the virtual reduction coping.

Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: A computer-implemented method of generating a reduction coping includes receiving a digital model comprising a virtual preparation tooth, determining one or more virtual reduction regions on the virtual preparation tooth, and generating a virtual reduction coping comprising one or more exposed regions corresponding to the one or more virtual reduction regions. A method of generating a physical reduction coping includes receiving a 3D digital model of a virtual reduction coping and performing additive manufacturing to generate a physical reduction coping from the virtual reduction coping.

Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: A computer-implemented method of generating a reduction coping includes receiving a digital model comprising a virtual preparation tooth, determining one or more virtual reduction regions on the virtual preparation tooth, and generating a virtual reduction coping comprising one or more exposed regions corresponding to the one or more virtual reduction regions. A method of generating a physical reduction coping includes receiving a 3D digital model of a virtual reduction coping and performing additive manufacturing to generate a physical reduction coping from the virtual reduction coping.

Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: Apparatus for producing finished dental restorations at the dentist's chair side from 3D CAD data. These restorations may be manufactured from ceramics, metals and polymers via subtractive means i.e. milling and grinding. A polar compact mechanism has been employed with the implementation of an inverse kinematic transform in the machine control to allow Cartesian programming. The margin following tool path is very computationally intensive and requires many minutes of calculation time and numerical control programs in excess of 10 mb for a typical restoration. Conventionally this would require the user to wait several minutes before running the machine which would increase the wait time for both the patient and the doctor. This problem is solved by allowing the program to be generated in parallel with the machine in the process of actually cutting the restoration.

Abstract: A method is provided for shaping a custom dental restoration from a preform, wherein the preform comprises a preform body and a preform stem. A method is further disclosed for generating one or more nesting positions for the restoration design within the geometry of the preform body relative to the position of the preform stem. A method is further disclosed for generating machining instructions based on the selected nesting position to optimize machining for chair-side applications.

Abstract: Apparatus for producing finished dental restorations at the dentist's chair side from 3D CAD data. These restorations may be manufactured from ceramics, metals and polymers via subtractive means i.e. milling and grinding. A polar compact mechanism has been employed with the implementation of an inverse kinematic transform in the machine control to allow Cartesian programming. The margin following tool path is very computationally intensive and requires many minutes of calculation time and numerical control programs in excess of 10 mb for a typical restoration. Conventionally this would require the user to wait several minutes before running the machine which would increase the wait time for both the patient and the doctor. This problem is solved by allowing the program to be generated in parallel with the machine in the process of actually cutting the restoration.

Abstract: Compounds according to Formula (I) or a salt thereof are selective ligands for GABAA receptors useful for treatment of disorders of the central nervous system:

Abstract: Compounds according to Formula (I) or a salt thereof are selective ligands for GABAA receptors useful for treatment of disorders of the central nervous system: 1

Abstract: Substituted 1H-Pyridinyl-2-ones are useful as GABAA-Alpha 2/3 ligands.

Abstract: A class of fused tricyclic heteroaromatic compounds of formula (I) as defined in claim 1 or a salt thereof or a prodrug thereof, containing a fused pyrazole, oxazole or pyrimidine ring are ligands for dopamine receptor subtypes within the body and are therefore of use in the treatment and/or prevention of disorders of the dopamine system, such as schizophrenia.

Abstract: A class of heteroaromatic compounds incorporating a substituted five-membered heteroaromatic nucleus which contains at least two nitrogen atoms are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia and depression.