Patents by Inventor David Leonardo

David Leonardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotide encoding human netrin-1
    Patent number: 6218526
    Abstract: Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein, a natural intracellular netrin protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said netrin protein selectively binds said binding target; and detecting the presence or absence of specific binding of said netrin protein to said binding target.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: April 17, 2001
    Assignees: The Regents of the University of California, Exelixis Pharmaceuticals, Inc.
    Inventors: Candace Swimmer, Anne Shyjan, David Leonardo, Yuan Zhang, Timothy Kennedy, Tito Serafini, Marc Tessier-Lavigne
  • Neurological drug screens
    Patent number: 6087326
    Abstract: Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: July 11, 2000
    Assignee: The Regents of the University of California
    Inventors: Lindsay Hinck, Kasuko Masu, Masayuki Masu, David Leonardo, Marc Tessier-Lavigne
  • Human netrin-1
    Patent number: 5824775
    Abstract: Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein, a natural intracellular netrin protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said netrin protein selectively binds said binding target; and detecting the presence or absence of specific binding of said netrin protein to said binding target.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: October 20, 1998
    Assignee: The Regents of the University of California
    Inventors: Candace Swimmer, Anne Shyjan, David Leonardo, Yuan Zhang, Timothy Kennedy, Tito Serafini, Marc Tessier-Lavigne
  • Neurological drug screens
    Patent number: 5747262
    Abstract: Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: May 5, 1998
    Assignee: The Regents of the University of California
    Inventors: Lindsay Hinck, Kasuko Masu, Masayuki Masu, David Leonardo, Marc Tessier Lavigne