Abstract: A subject target tissue specific template device (300) that includes a block of material (302) and a plurality of apertures (310) in the material. An aperture of the plurality of apertures is located in the block of material at a location that corresponds to an area of interest identified in an image of an anatomical region of interest of a subject and transferred to an image of block of material with no aperture, which is geometrically aligned with the image of the anatomical region of interest of the subject. A method includes aligning, with a computing system, an image of anatomical tissue of interest with an image of a grid, marking at least one area of interest of tissue of interest within the image of tissue of interest, transferring the marking to the image of the grid, and saving the image of a grid with the marking as a file in an electronic format.

Abstract: A subject target tissue specific template device (300) that includes a block of material (302) and a plurality of apertures (310) in the material. An aperture of the plurality of apertures is located in the block of material at a location that corresponds to an area of interest identified in an image of an anatomical region of interest of a subject and transferred to an image of block of material with no aperture, which is geometrically aligned with the image of the anatomical region of interest of the subject. A method includes aligning, with a computing system, an image of anatomical tissue of interest with an image of a grid, marking at least one area of interest of tissue of interest within the image of tissue of interest, transferring the marking to the image of the grid, and saving the image of a grid with the marking as a file in an electronic format.

Abstract: The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region 1 such that if at least two of the cysteine residues are not conjugated to another compound a disulphide bond forms between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides a protein that binds to TAG72. The present invention also provides conjugates of the protein and another compound.

Abstract: The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region 1 such that if at least two of the cysteine residues are not conjugated to another compound a disulphide bond forms between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides a protein that binds to TAG72. The present invention also provides conjugates of the protein and another compound.

Abstract: A mobile communication apparatus including a display and means for navigating among items displayed on the display, arranged to display a first list of items belonging to a higher hierarchical level on the display and being capable of enabling selection of a first item among the higher hierarchical level items by the means for navigation is disclosed. Upon selection of the first item, being arranged to insert and display a second list including at least one item belonging to a lower hierarchical level between the first item and subsequent higher hierarchical level items for enabling selection of a second item from the second list, wherein the second list is hierarchically associated with the first item. A corresponding application, apparatus and computer program are also disclosed.

Abstract: A method of making a microenvironmental sensor for neurological use in which the sensor is formed on a silicon wafer by the use of known integrated circuit techniques. A mask is applied to define the outline of the sensor, trenches are etched surrounding the sensor by the use of an anisotropic etchant and the sensor is separated by etching surplus silicon from the rear surface of the wafer.