Abstract: A system and method to control the review and publication of affinities. The system and method can be tailored to provide flexibility in the ways that affinity publication is controlled, thereby accommodating different cultural and legal constraints on information access. In one aspect, the system and method allows a person who is the subject of a proposed affinities to review the affinity and then approve or deny publication of the affinity before the affinity is made known to others, thus avoiding inappropriate publication. Advantageously, the system and method enable the person to review the affinity in a context that increases the likelihood that only accurate affinities will be published.

Abstract: A system, method, and processor readable medium for processing data in a knowledge management system gathers information content and transmits a work request for the information content gathered. The information content may be registered with a content map and assigned a unique document identifier. A work queue processes the work requests. The processed information may then be transmitted to another work queue for further processing. Further processing may include categorization, full-text indexing, metrics extraction or other process. Control messages may be transmitted to one or more users providing a status of the work request. The information may be analyzed and further indexed. A progress statistics report may be generated for each of the processes performed on the document. The progress statistics may be provided in a record. A shared access to a central data structure representing the metrics history and taxonomy may be provided for all work queues via a CORBA service.

Abstract: The present invention enables a flexible system for representing relationships among computing resources, assigning them strengths, and versioning them over time. One advantage is that all of the various ways that these entities are named in the real world can be normalized into a common model of identifiers (IDs) and types such that universal manipulations by class are possible without losing the capability to present the resulting information back with the original entity names or even with multiple equivalent names.

Abstract: A backup volume on a backup system is created/updated by reading data stored on a host volume on a host system. A data profile for the host volume is generated based on the read data, where the data profile characterizes the data stored on the host volume. The data profile is sent to the backup system, and data that does not need to be obtained from the host system is determined on the backup system based on the data profile.

Abstract: A dynamic block transfer size adjustment mechanism independently defines block transfer size for each memory portion, which may include files in a file system, virtual storage segments in a memory system, or extents in physical storage. By specifying block transfer size for a memory portion independently from other memory portions, the performance of the computer system may be enhanced. In addition, the block transfer size of one or more memory portions may be dynamically adjusted according to how the memory portion is used. In an alternative embodiment, the block transfer size may also be specified for each process that accesses a portion of memory. Thus, a single file may be accessed with a first block transfer size by a first process, and may be accessed with a second (different) block transfer size by a second process.

Abstract: This invention provides compounds of the formula: wherein: X is a chemical bond, —CH2— or —C(O)—; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, phenyl or benzyl; R2 is H, alkyl, cycloalkyl, —CH2-cycloalkyl, or perfluoroalkyl; R3 is H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, —CH2-cycloalkyl, —NH2, or —NO2; R4 is optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or —CH2-pyridinyl, or the salt or ester forms thereof, as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.

Abstract: This invention provides compounds of the formula: wherein: X is a chemical bond, —CH2— or —C(O)—; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, phenyl or benzyl; R2 is H, alkyl, cycloalkyl, —CH2-cycloalkyl, or perfluoroalkyl; R3 is H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, —CH2-cycloalkyl, —NH2, or —NO2; R4 is optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or —CH2-pyridinyl, or the salt or ester forms thereof, as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.

Abstract: A filtration assembly operable in connection with a crystal form screening workstation that provides for automated crystal form screening is disclosed. The assembly includes first and second valves, with each valve having an internal passage and first, second and third ports. A filter line is interposed between the first and second valves in fluid communication with the second port of the first valve and the second port of the second valve. A filter medium is in disposed in or at the end of the filter line and adapted to filter a drug-containing suspension flowing through the filter line. The filter medium is operable to filter fluids under both positive and negative pressure conditions.

Abstract: This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; R5 is H, alkyl, perfluoroalkyl, aryl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R6 is H, alkyl, alkylaryl, benzyl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R7 is H, alkyl, alkylaryl, aryl optionally substituted with R8; n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO3H, PO3H2, tetronic acid, etc.; R8 is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.

Abstract: This invention provides PAI-1 inhibiting compounds of Formula I: 1

Abstract: A dynamic block transfer size adjustment mechanism independently defines block transfer size for each memory portion, which may include files in a file system, virtual storage segments in a memory system, or extents in physical storage. By specifying block transfer size for a memory portion independently from other memory portions, the performance of the computer system may be enhanced. In addition, the block transfer size of one or more memory portions may be dynamically adjusted according to how the memory portion is used. In an alternative embodiment, the block transfer size may also be specified for each process that accesses a portion of memory. Thus, a single file may be accessed with a first block transfer size by a first process, and may be accessed with a second (different) block transfer size by a second process.

Abstract: This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are eachH, alkyl,, alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; R5 is H, alkyl, perfluoroalkyl, aryl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R6 is H, alkyl, alkylaryl, benzyl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R7 is H, alkyl, alkylaryl, aryl optionally substituted with R8; n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO3H, PO3H2, tetronic acid, etc.; R8 is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.

Abstract: A backup volume on a backup system is created/updated by reading data stored on a host volume on a host system. A data profile for the host volume is generated based on the read data, where the data profile characterizes the data stored on the host volume. The data profile is sent to the backup system, and data that does not need to be obtained from the host system is determined on the backup system based on the data profile.

Abstract: A filter circuit for removing noise and harmonic frequencies from alternating current power sources. The result of which will improve the performance of audio or video devices powered by said power source. The filter does not limit power flow to the load device. The basis of the filter is an inductor and capacitor tuned to the fundamental frequency of the power line.

Abstract: This invention provides compounds which act as inhibitors of plasminogen activator inhibitor-1 (PAI-1) of the formula: wherein: R, R1, R2, and R3 are H, alkyl, cycloalkyl, —CH2-(cycloalkyl), alkanoyl, halo, hydroxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, perfluoroalkyl, alkoxy, amino, —NH(alkyl), —N(alkyl)2, or perfluoroalkoxy; R4 is H, alkyl, perflouroalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, alkenyl-aryl, aryl, —CH2R5, —CH(OH)R5, —C(O)R5, —CH(SH)R5, or —C(S)R5; R5 is H, alkyl, perflouroalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, alkenyl-aryl; R6 is H, alkyl, cycloalkyl, —CH2-cycloalkyl, alkylaryl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; n is an integer of 0-6; A is COOH, or an acid mimic; or a pharmaceutically acceptable salt or ester form thereof, as well as pharmaceutical compositions and methods using these compounds to treat

Abstract: A method and system for reducing a reflection coefficient below a predetermined value thereby reducing jitter by the variation of the effective impedance of a driver appearing to be bounded during state transitions. The driver may include a pull-up driver and a pull-down driver. In the pull-up driver, the transistors may be switched from a first state to a second state in a staggered fashion where the first state is complementary to the second state; In the pull-down driver, the transistors may be switched from a second state to a first state in a staggered fashion. By staggering the switching of the transistors in the pull-up driver and the pull-down driver, a portion of the current may flow from the pull-up driver to the pull-down driver thereby causing the variation of the effective impedance of the driver to appear to be bounded during state transitions.

Abstract: The present invention enables a flexible system for representing relationships among computing resources, assigning them strengths, and versioning them over time. One advantage is that all of the various ways that these entities are named in the real world can be normalized into a common model of identifiers (IDs) and types such that universal manipulations by class are possible without losing the capability to present the resulting information back with the original entity names or even with multiple equivalent names.

Abstract: A system and method to control the review and publication of affinities. The system and method can be tailored to provide flexibility in the ways that affinity publication is controlled, thereby accommodating different cultural and legal constraints on information access. In one aspect, the system and method allows a person who is the subject of a proposed affinities to review the affinity and then approve or deny publication of the affinity before the affinity is made known to others, thus avoiding inappropriate publication. Advantageously, the system and method enable the person to review the affinity in a context that increases the likelihood that only accurate affinities will be published.

Abstract: A system and method for mining a user's e-mail and for generating a list of categories based on the e-mail content. The generated category list is compared to a master category list and those categories included in the generated category list that are not included in the master category list are removed from the generated category list. For each category remaining in the generated category list, the system and method calculates an affinity value, which represents the strength of the user's relationship to the category. The affinity (i.e., the concept plus the affinity value) may be submitted to an affinity publisher module that uses an affinity publication policy in determining whether or not to publish the affinity.