Patents by Inventor David Lesikar

David Lesikar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
    Publication number: 20050186143
    Abstract: The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 ?-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).
    Type: Application
    Filed: November 17, 2004
    Publication date: August 25, 2005
    Applicant: Nektar Therapeutics
    Inventors: Cynthia Stevenson, Jayne Hastedt, S. Lehrman, Hi-Shi Chiang, David Bennett, David Lesikar, Bing Yang, David Gong, Kirsten Cabot
  • Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
    Patent number: 6838075
    Abstract: The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 ?-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: January 4, 2005
    Assignee: Nektar Therapeutics
    Inventors: Cynthia Stevenson, Jayne E. Hastedt, Russ Lehrman, Hi-Shi Chiang, David B. Bennett, David Lesikar, Bing Yang, David Gong, Kirsten Cabot
  • Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
    Publication number: 20030190291
    Abstract: The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 &agr;-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).
    Type: Application
    Filed: March 14, 2003
    Publication date: October 9, 2003
    Applicant: Nektar Therapeutics
    Inventors: Cynthia Stevenson, Jayne E. Hastedt, S. Russ Lehrman, Hi-Shi Chiang, David B. Bennett, David Lesikar, Bing Yang, David Gong, Kirsten Cabot
  • Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
    Patent number: 6569406
    Abstract: The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 &agr;-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: May 27, 2003
    Assignee: Nektar Therapeutics
    Inventors: Cynthia Stevenson, Jayne E. Hastedt, S. Russ Lehrman, Hi-Shi Chiang, David B. Bennett, David Lesikar, Bing Yang, David Gong, Kirsten Cabot
  • Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
    Publication number: 20020065399
    Abstract: The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 &agr;-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).
    Type: Application
    Filed: August 7, 2001
    Publication date: May 30, 2002
    Applicant: Inhale Therapeutic Systems, Inc.
    Inventors: Cynthia Stevenson, Jayne E. Hastedt, S. Russ Lehrman, Hi-Shi Chiang, David B. Bennett, David Lesikar, Bing Yang, David Gong, Kirsten Cabot
  • Surfactant compositions and methods
    Patent number: 5876970
    Abstract: Stable lung surfactant compositions are provided, as well as methods for their preparation, modification, formulation, assay, and therapeutic use.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: March 2, 1999
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventors: Bradley J. Benson, John H. Frenz, Cynthia P. Quan, Steven Shak, Kathleen A. Shiffer, Michael C. Venuti, John T. Stults, David Lesikar
  • Isolation and purification of lung surfactant protein
    Patent number: 5403915
    Abstract: Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C.sub.1 -C.sub.4 aliphatic alcohol and chromatographic purification steps which employ a C.sub.1 -C.sub.4 aliphatic alcohol as eluant. Purified proteins obtained using the disclosed isolation and purification steps are provided as well.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: April 4, 1995
    Assignee: Scios Nova Inc.
    Inventors: Bradley J. Benson, Douglas Buckley, David Lesikar, Asha Naidu, Kate B. Silverness
  • Isolation and purification of lung surfactant protein
    Patent number: 5258496
    Abstract: Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C.sub.1 -C.sub.4 aliphatic alcohol and chromatographic purification steps which employ a C.sub.1 -C.sub.4 aliphatic alcohol as eluant. Purified proteins obtained using the disclosed isolation and purification steps are provided as well.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: November 2, 1993
    Assignee: Scios Nova Inc.
    Inventors: Bradley J. Benson, Douglas Buckley, David Lesikar, Asha Naidu, Kate B. Silverness