Patents by Inventor David Lessard
David Lessard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10561735Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: GrantFiled: November 20, 2017Date of Patent: February 18, 2020Assignees: Paladin Labs Inc., Paladin Labs Europe Limited, Paladin Labs (Barbados) Inc.Inventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Patent number: 10252657Abstract: A headrest for a seat of a vehicle includes a body securable to the seat, a side portion adjacent the body, a receiver pivotally attached to the body, a slide attached to the side portion so as to be movable along the receiver between a first position in which the side portion is in a retracted position and a second position in which the side portion is in an extended position, and a friction member on one of the receiver and the slide. A securing mechanism causes the friction member to hold the slide in a selected position relative to the receiver.Type: GrantFiled: December 4, 2015Date of Patent: April 9, 2019Assignee: BOMBARDIER INC.Inventor: David Lessard
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Publication number: 20180140706Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: November 20, 2017Publication date: May 24, 2018Inventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Publication number: 20170368970Abstract: A headrest for a seat of a vehicle includes a body securable to the seat, a side portion adjacent the body, a receiver pivotally attached to the body, a slide attached to the side portion so as to be movable along the receiver between a first position in which the side portion is in a retracted position and a second position in which the side portion is in an extended position, and a friction member on one of the receiver and the slide. A securing mechanism causes the friction member to hold the slide in a selected position relative to the receiver.Type: ApplicationFiled: December 4, 2015Publication date: December 28, 2017Inventor: David LESSARD
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Publication number: 20160193341Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: September 3, 2015Publication date: July 7, 2016Inventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Publication number: 20140323587Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: December 19, 2013Publication date: October 30, 2014Applicants: PALADIN LABS INC., PALADIN LABS (BARBADOS) INC., PALADIN LABS EUROPE LIMITEDInventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Publication number: 20130039864Abstract: The disclosure relates to a non-intravenous dosage for administration of a liquid biologically active agent. The dosage form contains a solid formulation of the liquid biologically active agent, e.g. propofol, in intimate association with at least one stabilizing agent, e.g. an amphiphilic polymer or surfactant. A liquid biologically active agent is converted to a solid product, e.g. a powder, that can be easily incorporated into a number of different non-intravenous dosage forms. Upon hydration, a nanodispersion or micelle loaded with the active agent is formed. The dosage form can provide a non-intravenous route of administration for active agents that are typically only administered intravenously. Methods, uses, kits and commercial packages related to the non-intravenous dosage form are also disclosed.Type: ApplicationFiled: April 21, 2011Publication date: February 14, 2013Inventors: Francois Ravenelle, Dorothee Le Garrec, David Lessard, Sandra Gori, Damon Smith, Miloud Rahmouni, Vinayak Sant
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Publication number: 20120289606Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: July 19, 2012Publication date: November 15, 2012Inventors: François Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothée Le Garrec, Damon Smith
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Patent number: 7838600Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: GrantFiled: September 16, 2008Date of Patent: November 23, 2010Assignees: Labopharm, Inc., Labopharm Europe Limited, Labopharm (Barbados) LimitedInventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
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Publication number: 20090258071Abstract: The invention provides compositions and methods for the targeted, in particular, pH targeted, delivery of pharmaceutically active agents in mammals. The compositions comprise pH sensitive diblock copolymers, which permit the release of the pharmaceutically active agent when exposed to an environment having a particular pH. The compositions are particularly useful for the oral delivery of water insoluble pharmaceutically active agents.Type: ApplicationFiled: March 20, 2009Publication date: October 15, 2009Applicant: Labopharm, Inc.Inventors: David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Publication number: 20090012240Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: ApplicationFiled: September 16, 2008Publication date: January 8, 2009Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
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Publication number: 20080027205Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: ApplicationFiled: August 6, 2007Publication date: January 31, 2008Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Liu
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Patent number: 7262253Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: GrantFiled: December 2, 2003Date of Patent: August 28, 2007Assignee: Labopharm, Inc.Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
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Publication number: 20070182055Abstract: A method of forming a coated medical device is described. A coating may be applied inline to a continuous tubing formed by extrusion, prior to cutting and secondary operations. Thus, inefficient and labor-intensive steps associated with preparing individual tubes for coating may be avoided. The method may include forcing a flowable material through an exit port of an extruder, depositing a coating onto at least a portion of the continuous length of extruded tubing after the tubing is forced through the exit port, cutting the coated tubing to a desired length after depositing the coating, and performing one or more secondary operations on the coated tube at a temperature in the range of from about 15° C. to about 375° C.Type: ApplicationFiled: February 1, 2007Publication date: August 9, 2007Applicants: Cook Incorporated, Sabin CorporationInventors: Scott Eells, David Lessard
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Publication number: 20060212110Abstract: Described are vascular valve devices having valve elements formed of flexible material and at least one removable frame element. Also described are methods for using such devices in the vascular system and in particular in the venous system to treat venous insufficiency.Type: ApplicationFiled: March 17, 2004Publication date: September 21, 2006Inventors: Thomas Osborne, Brian Case, David Lessard, Neal Fearnot
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Publication number: 20060198891Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: November 25, 2005Publication date: September 7, 2006Inventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Garrec, Damon Smith
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Publication number: 20060016064Abstract: A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein.Type: ApplicationFiled: March 30, 2004Publication date: January 26, 2006Inventors: Scott Boatman, David Burton, Michael Hoffa, Thomas Osborne, David Drewes, David Lessard, Maggie Hupcey
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Publication number: 20050119404Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: ApplicationFiled: December 2, 2003Publication date: June 2, 2005Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Liu
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Publication number: 20050059958Abstract: Catheters having an overmolded hub are disclosed. The overmolded catheter hubs may include one or more access hubs that are overmolded with an overmold material. The catheter hub may also be formed as a single piece from the overmold material. The overmolded construction can result in a stronger bond between the catheter body and the hub and can provide for access hubs having sufficient clarity for the observation of air bubbles in a contained fluid. The disclosed catheter hubs may also demonstrate improved balloon deflation rates when utilized with a catheter body having a distal balloon.Type: ApplicationFiled: September 9, 2004Publication date: March 17, 2005Inventors: David Lessard, Scott Eells, Gregory Frankland, David Drewes