Abstract: A network address server is configured to resolve a target network address name label with a network address, with the target address name label defining a branch of one level of a multi-level network address name space. The network address server is one of a plurality of network address servers each being uniquely associated with a respective region of the address name space level. The network server includes an address name database, and an address name processor in communication with the address name database for providing a response to a query for the network address corresponding to the target address name label. The address name database includes a number of database records, each identifying a unique address name label and a network address uniquely associated with the address name label.

Abstract: DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.

Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.

Abstract: An electronic mail server is provided to facilitate e-mail communication over a network. The electronic mail server includes an account name database and an account name processor in communication with the account name database for providing a response to a message received over the network. Typically, the message includes an e-mail account name label comprising at least one account name character (having an account name character set type), with the character set type including a non-ASCII compatible character set. The account name database includes a number of database records, each identifying an e-mail account name comprising at least one record character having a record character set type, and a record character set identifier identifying the record character set type. The account name processor includes a correlation processor and a response processor.

Abstract: An electronic mail server is provided to facilitate e-mail communication over a network. The electronic mail server includes an account name database and an account name processor in communication with the account name database for providing a response to a message received over the network. Typically, the message includes an e-mail account name label comprising at least one account name character (having an account name character set type), with the character set type including a non-ASCII compatible character set. The account name database includes a number of database records, each identifying an e-mail account name comprising at least one record character having a record character set type, and a record character set identifier identifying the record character set type. The account name processor includes a correlation processor and a response processor.

Abstract: Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.

Abstract: Described are on-die termination (ODT) systems and methods that facilitate high-speed communication between a transmitter die and a receiver die interconnected via one or more signal transmission lines. An ODT control system in accordance with one embodiment calibrates and maintains the termination resistances for the signal transmission lines. The ODT control system derives a number of calibration currents from precision voltage and resistance references and distributes the reference currents to a number of transmitters. Each transmitter then derives an ODT calibration signal using the respective reference current and another precision resistor, and then employs the calibration signal to calibrate local termination elements. Distributing calibrated currents provides excellent noise immunity, while limiting the requisite number of external voltage references reduces cost.

Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPMT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.

Abstract: Described are on-die termination (ODT) systems and methods that facilitate high-speed communication between a transmitter die and a receiver die interconnected via one or more signal transmission lines. An ODT control system in accordance with one embodiment calibrates and maintains the termination resistances for the signal transmission lines. The ODT control system derives a number of calibration currents from precision voltage and resistance references and distributes the reference currents to a number of transmitters. Each transmitter then derives an ODT calibration signal using the respective reference current and another precision resistor, and then employs the calibration signal to calibrate local termination elements. Distributing calibrated currents provides excellent noise immunity, while limiting the requisite number of external voltage references reduces cost.

Abstract: There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.

Abstract: Described are on-die termination (ODT) systems and methods that facilitate high-speed communication between a transmitter die and a receiver die interconnected via one or more signal transmission lines. An ODT control system in accordance with one embodiment calibrates and maintains the termination resistances for the signal transmission lines. The ODT control system derives a number of calibration currents from precision voltage and resistance references and distributes the reference currents to a number of transmitters. Each transmitter then derives an ODT calibration signal using the respective reference current and another precision resistor, and then employs the calibration signal to calibrate local termination elements. Distributing calibrated currents provides excellent noise immunity, while limiting the requisite number of external voltage references reduces cost.

Abstract: A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.

Abstract: There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.

Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-&bgr; activity.

Abstract: An electronic mail server is provided to facilitate e-mail communication over a network. The electronic mail server includes an account name database and an account name processor in communication with the account name database for providing a response to a message received over the network. Typically, the message includes an e-mail account name label comprising at least one account name character (having an account name character set type), with the character set type including a non-ASCII compatible character set. The account name database includes a number of database records, each identifying an e-mail account name comprising at least one record character having a record character set type, and a record character set identifier identifying the record character set type. The account name processor includes a correlation processor and a response processor.

Abstract: A network address server is configured to resolve a target network address name label with a network address, with the target address name label defining a branch of one level of a multi-level network address name space. The network address server is one of a plurality of network address servers each being uniquely associated with a respective region of the address name space level. The network server includes an address name database, and an address name processor in communication with the address name database for providing a response to a query for the network address corresponding to the target address name label. The address name database includes a number of database records, each identifying a unique address name label and a network address uniquely associated with the address name label.

Abstract: A method for high-throughput genomics analysis, to identify the therapeutic or diagnostic utility of genes, entails the use of a construct to disrupt a gene or alleles of a gene in cells of interest. Arrays of such cells can be used to monitor such disrupted cells phenotypically in the context, for example, of testing drug candidates. Polynucleotides that comprise part of the disrupted genes can be recovered from such “knockout” cells, by virtue of an origin of replication or a host cell selection marker sequence that is part of the construct. The recovered polynucleotides can be used to identify the disrupted genes or to make homologous recombination vectors, which in turn can be employed to make multi-allele knockout cells. Double-stranded RNA molecules designed to target the recovered polynucleotide are used to downregulate the polynucleotide in vitro and in vivo, following determination of a therapeutically effective dosage of the RNAi molecule.

Abstract: A method for high-throughput genomics analysis, to identify the therapeutic or diagnostic utility of genes, entails the use of a construct to disrupt a gene or alleles of a gene in cells of interest. Arrays of such cells can be used to monitor such disrupted cells phenotypically in the context, for example, of testing drug candidates. Polynucleotides that comprise part of the disrupted genes can be recovered from such “knockout” cells, by virtue of an origin of replication or a host cell selection marker sequence that is part of the construct. The recovered polynucleotides can be used to identify the disrupted genes or to make homologous recombination vectors, which in turn can be employed to make multi-allele knockout cells.

Abstract: A method for high-throughput, genomics analysis, to identify the therapeutic or diagnostic utility of genes, entails the use of a construct to disrupt a gene or alleles of a gene in cells of interest. Arrays of such cells can be used to monitor such disrupted cells phenotypically in the context, for example, of testing drug candidates. Polynucleotides that comprise part of the disrupted genes can be recovered from such “knockout” cells, by virtue of an origin of replication or a host cell selection marker sequence that is part of the construct. The recovered polynucleotides can be used to identify the disrupted genes or to make homologous recombination vectors, which in turn can be employed to make multi-allele knockout cells.

Abstract: A reference voltage generator for producing a regulated, temperature-compensated output voltage from an unregulated power supply voltage is provided herein. The reference voltage generator includes a pre-regulating circuit and a temperature-compensating circuit. The temperature compensating circuit includes a first series path comprising a first cascode current sources and a first resistor; a second series path comprising a second cascode current source, a first field effect transistor and a first diode; and a third series path comprising a third cascode current source, a second field effect transistor, a second resistor and a second diode. The first series path being connected to the second series path between the first field resistor and the first diode.