Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

Abstract: or a salt (e.g., pharmaceutically acceptable salt) or stereoisomer thereof, wherein X, Y, R1a, R1b, R2, R3, R4s, R5, p, and n are as defined herein. Use of the compounds as a component of a pharmaceutical compositions and methods for their use are also provided.

Abstract: Navigation based on internal state inference and interactivity estimation may include training a policy for autonomous navigation by extracting spatio-temporal features from one or more historical observations of one or more agents within a simulation environment including an ego-agent, analyzing the spatio-temporal features to infer one or more internal states of one or more of the agents, predicting one or more future behaviors for one or more of the one or more of the agents in a first scenario including an existence of the ego-agent within the simulation environment and in a second scenario excluding the existence of the ego-agent within the simulation environment, and calculating one or more interactivity scores for one or more of the agents based on a difference between the first scenario and the second scenario. The trained policy may be implemented to control an autonomous vehicle.

Abstract: Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.

Abstract: A honeycomb body having a repeating channel structure formed of intersecting porous walls. The repeating channel structure comprises a first channel type defined by at least four first surfaces, at least two of the at least four first surfaces are parallel to one another; and a second channel type having at least four second surfaces, wherein four or more of the at least four second surfaces are non-parallel with one another. Repeating channel structure is repeated in the honeycomb body. Honeycomb extrusion dies and methods of manufacturing the honeycomb body are provided, as are other embodiments.

Abstract: Pharmaceutical compositions comprising filgotinib maleate Form I characterized by an XRPD pattern substantially the same as shown in FIG. 1 and uses thereof are described herein.

Abstract: Oral care based imaging computer-implemented systems and methods for determining perceived attractiveness of a facial image portion of at least one person depicted in a digital image. The method has the following steps: a) obtaining a digital image comprising at least one oral feature of at least one person, wherein the digital image includes a facial image portion of the at least one person, the facial image portion having both positive and negative attributes as defined by pixel data of the digital image; b) analyzing the facial image portion; c) generating an Attractiveness Score indicative of a perceived attractiveness of the facial image portion based on the analyzed facial image portion in the obtained digital image; d) further generating an image description that identifies at least one area in said facial image portion based on the Attractiveness Score; and e) presenting the image description to a use.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating images. In one aspect, a method includes: receiving an input text prompt including a sequence of text tokens in a natural language; processing the input text prompt using a text encoder neural network to generate a set of contextual embeddings of the input text prompt; and processing the contextual embeddings through a sequence of generative neural networks to generate a final output image that depicts a scene that is described by the input text prompt.

Abstract: Apparatus include a first laser diode situated to emit a beam from an exit facet along an optical axis, the beam as emitted having perpendicular fast and slow axes perpendicular to the optical axis, a first fast axis collimator (FAC) optically coupled to the beam as emitted from the exit facet and configured to direct the beam along a redirected beam axis having a non-zero angle with respect to the optical axis of the first laser diode, a second laser diode situated to emit a beam from an exit facet of the second laser diode along an optical axis parallel to the optical axis of the first laser diode and with a slow axis in a common plane with the slow axis of the first laser diode, and a second fast axis collimator (FAC) optically coupled to the beam as emitted from the exit facet of the second laser diode and configured to direct the beam along a redirected beam axis having a non-zero angle with respect to the optical axis of the second laser diode.

Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Abstract: A method and system for obtaining an identifier from an item is disclosed. The method includes autonomously operating a robotic structure having a robotic arm to pick an item using an end effector of the robotic arm along a predetermined path from a source location to a destination location according to a plan. The picked item is moved according to the plan. An active measure is determined to be performed at least in part to obtain an identifier determined to be missing based on information received via the communication interface from one or more sensors. The robotic structure is autonomously operated to place the item at the destination location based at least in part on the plan.

Abstract: The subject technology receives, by a client device from a storage device, first image data captured by the client device at a previous time. The subject technology receives first metadata corresponding to at least a first image processing operation and a second image processing operation. The subject technology generates, in a first render pass, second image data based on the first metadata and the image processing operation performed on the first image data. The subject technology generates, in a second render pass, third image data based on the first metadata and the second image processing operation performed on the second image data. The subject technology generates second metadata comprising information corresponding to the third image data. The subject technology generates a composite AR content item comprising the second metadata, the third image data, and the first image data.

Abstract: The disclosure concerns an augmented reality method in which visual information concerning a real-world object, structure or environment is gathered and a deformation operation is performed on that visual information to generate virtual content that may be displayed in place of, or additionally to, real-time captured image content of the real-world object, structure or environment. Some particular embodiments concern the sharing of visual environment data and/or information characterizing the deformation operation between client devices.

Abstract: Voice-controlled devices that include one or more speakers for outputting audio. In some instances, the device includes at least one speaker within a cylindrical housing, with the speaker aimed or pointed away from a microphone coupled to the housing. For instance, if the microphone resides at or near the top of the cylindrical housing, then the speaker may point downwards along the longitudinal axis of the housing and away from the microphone. By pointing the speaker away from the microphone, the microphone will receive less sound from the speaker than if the speaker were pointed toward the microphone). Because the voice-controlled device may perform speech recognition on audio signals generated by the microphone, less sound from the speaker represented in the audio signal may result in more accurate speech recognition, and/or a lesser need to perform acoustic echo cancelation (AEC) on the generated audio signals.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.

Abstract: A calibration method for determining angles between an image acquisition module reference frame and an accelerometer reference frame of a portable electronic device.

Abstract: A method and system for automated and semi-automated predictable, consistent, safe, effective, and lumen-specific and patient-specific cryospray treatment of airway tissue in which treatment duration is automatically set by the system following entry of patient information and treatment location information into the system by the user, and treatment spray is automatically stopped by the system when the automatically selected treatment duration has been achieved as determined by the system.

Abstract: Appliances for intraoral delivery of agents are provided. In some embodiments, an appliance includes a shell having an inner surface and an outer surface, the inner surface defining a plurality of tooth-receiving cavities configured to apply a repositioning force to a patient's teeth, and the outer surface oriented away from the patient's teeth. The appliance can also include a reservoir integrally formed in the outer surface of the shell, the reservoir being configured to store at least one agent. The appliance can further include a membrane covering at least a portion of the reservoir to control release of the agent into an intraoral cavity of the patient. The membrane can include a plurality of pores that are configured to open based at least in part on a temperature of the patient's intraoral cavity to allow the at least one agent to pass therethrough.