Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: Systems and methods for use in enabling multiple management activities for a business entity through a domain model are disclosed. One exemplary method includes receiving, in response to a user input, a change to a domain model. The domain model is representative of technology associated with a business entity, and the domain model defines multiple layers, each associated with one of infrastructure, a plurality of services, and/or a plurality of business products of the business entity. Each layer includes multiple assets. And, the domain model further defines at least one relationship between one of the multiple assets in one layer and at least one of the multiple assets in a different layer. The method further includes updating the domain model based on the change and exposing the updated domain model to multiple different management activities of the business entity.